Localized Laryngeal Amyloidosis

2002 ◽  
Vol 127 (5) ◽  
pp. 487-489 ◽  
Author(s):  
Aaron D. Friedman ◽  
Rajendra Bhayani ◽  
Lorenzo Memeo ◽  
Daniel B. Kuriloff
Keyword(s):  
Multiple Myeloma ◽  
Polarized Light ◽  
Vocal Folds ◽  
Excisional Biopsy ◽  
Body Sensation ◽  
Laryngeal Amyloidosis ◽  
False Vocal ◽  
Work Up ◽  
Localized Laryngeal Amyloidosis ◽  
Hyaline Material

A 54-year-old female schoolteacher presented with 1-month of hoarseness and a foreign body sensation in the back of her throat that was not associated with symptoms or signs of infection. Direct laryngoscopy showed bilateral, yellow, hyperemic masses on the false vocal folds and laryngeal ventricles Fig 1 . Both true vocal folds were mobile. An excisional biopsy of the mass revealed an amorphous, eosinophilic hyaline material Fig 2 that exhibited apple-green birefringence when stained with Congo red and viewed under polarized light Fig 3 , consistent with amyloidosis. There was no evidence of neoplasm. The work-up for systemic amyloidosis and multiple myeloma was negative. The patient did well over the next several years, but recurrence of the laryngeal amyloid tumor necessitated 2 additional conservative endoscopic CO2 laser excisions. Since her last surgery, the patient has remained asymptomatic.

Primary Localized Laryngeal Amyloidosis (LA)

Blood ◽  
2011 ◽  
Vol 118 (21) ◽  
pp. 4596-4596
Author(s):  
Matthew Richards ◽  
Kim Le ◽  
Mercedes Lorenzo-Medina ◽  
Langsjoen Dane ◽  
Carmen Arango ◽  
...  
Keyword(s):  
Vocal Cord ◽  
Conflicts Of Interest ◽  
Polarized Light ◽  
Rare Condition ◽  
B Cell Lymphoma ◽  
Laryngeal Amyloidosis ◽  
The Right ◽  
False Vocal ◽  
Localized Laryngeal Amyloidosis

Abstract Abstract 4596 Background: Localized Laryngeal Amyloidosis (LA) is a rare condition. There is limited understanding of its natural history. Our aim is to report the clinical evolution of a patient diagnosed with localized LA. Methods: Case report. Results: In May 2002, a 43-year-old gentleman presented with hoarseness and a CT scan of the neck showed a thickening of the right vocal cord with a mass that measured 2.9 × 1.2 cm in widest diameter. The patient had this mass removed surgically and the pathology showed a positive Congo red staining and a positive birefringence under polarized light, diagnostic of amyloidosis. No evidence of systemic amyloidosis or an overt B-cell lymphoma was found in this patient. Patient lost follow-up until October 2008 when he was found to have soft tissue induration around the left false vocal cord area. The biopsy showed again amyloidosis. Conclusions: LA recurrences can manifest several years after initial diagnosis. Long-term follow-up is essential. Disclosures: No relevant conflicts of interest to declare.

Localized Laryngeal Amyloidosis

2016 ◽  
Vol 6 (1) ◽  
pp. 32-34
Author(s):  
Gautam Khaund ◽  
Ronica Baruah ◽  
Abhijit Kalita
Keyword(s):  
Head And Neck ◽  
Vocal Cord ◽  
Final Diagnosis ◽  
Benign Disease ◽  
Systemic Diseases ◽  
Laryngeal Amyloidosis ◽  
False Vocal ◽  
Localized Laryngeal Amyloidosis

ABSTRACT Amyloidosis in head and neck is rare but a benign disease. Among the sites in head and neck, larynx is the most commonly involved. A 40-year-old female had presented with hoarseness of voice and dyspnea with a mass in false vocal cord, which was biopsied and diagnosed as amyloidosis. After excluding systemic diseases, final diagnosis of localized laryngeal amyloidosis was given. How to cite this article Baruah R, Khaund G, Kalita A. Localized Laryngeal Amyloidosis. Int J Phonosurg Laryngol 2016;6(1):32-34.

scholarly journals Laryngeal Involvement of Multiple Myeloma

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
Ariel B. Grobman ◽  
Richard J. Vivero ◽  
German Campuzano-Zuluaga ◽  
Parvin Ganjei-Azar ◽  
David E. Rosow
Keyword(s):  
Multiple Myeloma ◽  
Plasma Cell ◽  
Treatment Options ◽  
Tertiary Care ◽  
Vocal Folds ◽  
Pathologic Findings ◽  
Plasma Cell Neoplasms ◽  
History Of ◽  
False Vocal ◽  
Laryngeal Involvement

The objectives of this paper are to discuss a rare cause of laryngeal multiple myeloma, to review unique pathologic findings associated with plasma cell neoplasms, to discuss epidemiology, differential diagnosis, and treatment options for plasma cell neoplasms of the larynx. Laryngeal multiple myeloma, also noted in the literature as “metastatic” multiple myeloma, presenting as a de novo laryngeal mass is extremely rare with few reported cases. Laryngeal involvement of extramedullary tumors is reported to be between 6% and 18% with the epiglottis, glottis, false vocal folds, aryepiglottic folds, and subglottis involved in decreasing the order of frequency. We present the case of a 58-year-old male with a history of IgA smoldering myeloma who presented to a tertiary care laryngological practice with a two-month history of dysphonia, which was found to be laryngeal involvement of multiple myeloma. We review the classification of and differentiation between different plasma cell neoplasms, disease workups, pathologic findings, and treatment options.

Amyloidosis of the Larynx in a Child

1994 ◽  
Vol 103 (8) ◽  
pp. 590-594 ◽  
Author(s):  
Laurence R. O'Halloran ◽  
Rodney P. Lusk
Keyword(s):  
Vocal Cord ◽  
Thyroid Cartilage ◽  
Postoperative Recovery ◽  
True Vocal Cord ◽  
Vocal Process ◽  
Laryngeal Amyloidosis ◽  
Benign Process ◽  
Vocal Quality ◽  
False Vocal ◽  
Localized Laryngeal Amyloidosis

Localized laryngeal amyloidosis is a rare and benign process. Only three cases have been reported in children. We present the case of a 9-year-old girl with localized laryngeal amyloidosis that was excised via laryngofissure. The patient presented with a 3- to 4-week history of progressive hoarseness. Direct laryngoscopy revealed a smooth, firm, submucosal mass extending from the anterior aspect of the left false vocal cord to the vocal process. Biopsy of the mass revealed findings consistent with amyloidosis. The mass was approached via laryngofissure and excised with the thyroid cartilage and left true vocal cord left intact. An extensive workup for systemic amyloidosis was negative, including bone marrow biopsy. The postoperative recovery was uneventful, with good vocal quality and a sluggish but mobile left true vocal cord. This case is significant because of the young age of the child, the extent of disease, and the use of laryngofissure for excision.

Spontaneous perforation of cervical oesophagus: a rare variant of Boerhaave's syndrome

2009 ◽  
Vol 123 (12) ◽  
pp. 1378-1380 ◽  
Author(s):  
S Mittal ◽  
A Rohatgi ◽  
R P Sutcliffe ◽  
A Botha
Keyword(s):  
Vocal Folds ◽  
Sudden Onset ◽  
Water Soluble ◽  
Uneventful Recovery ◽  
Oesophageal Perforation ◽  
Nasogastric Feeding ◽  
Computed Tomography Scanning ◽  
Difficulty Breathing ◽  
The Right ◽  
False Vocal

AbstractBackground:A 29-year-old man presented with sudden onset of severe pain in his throat, difficulty breathing and a hoarse voice, following an episode of vomiting.Investigations:Initial laboratory tests were normal. The patient underwent fibre-optic nasendoscopy, which demonstrated a haematoma in the piriform fossa. Lateral neck radiography and subsequent computed tomography scanning confirmed a 2 cm, loculated, gas-containing collection at the level of the vallecula in the right posterolateral wall, extending to the false vocal folds and communicating between the right parapharyngeal space and the right carotid sheath. Water-soluble contrast swallow confirmed the diagnosis.Diagnosis:Contained oesophageal perforation.Management:Conservative treatment was adopted involving nil orally, intravenous antibiotics and nasogastric feeding. The patient made an uneventful recovery.

scholarly journals Focus on localized laryngeal amyloidosis: management of five cases

Open Medicine ◽  
2020 ◽  
Vol 15 (1) ◽  
pp. 327-332
Author(s):  
Massimo Mesolella ◽  
Gerardo Petruzzi ◽  
Sarah Buono ◽  
Grazia Salerno ◽  
Francesco Antonio Salzano ◽  
...  
Keyword(s):  
Systemic Disease ◽  
Clinical Aspects ◽  
Benign Tumors ◽  
Local Form ◽  
Systemic Involvement ◽  
Clinical Syndromes ◽  
Laryngeal Amyloidosis ◽  
And Control ◽  
Localized Laryngeal Amyloidosis

AbstractAmyloidosis is a group of idiopathic clinical syndromes caused by the deposition of insoluble fibrillar proteins (amyloid) in the extracellular matrix of organs and tissues. These deposits disrupt the function of the target organ. Amyloidosis can manifest as a systemic disease or a single-organ involvement (local form). Its etiology still remains unclear. Deposits of amyloid in the larynx are rare, accounting for between 0.2 and 1.2% of benign tumors of the larynx. In this retrospective study, we report the clinical aspects, diagnosis, treatment and follow-up of five female patients with localized laryngeal amyloidosis without systemic involvement. The patients were all treated successfully using microlaryngoscopy with CO2 laser or cold instruments. Prognosis is excellent; however, appropriate follow-up is an important part of the long-term management of this disease in order to prevent and control the possibility of local recurrence.

scholarly journals Occult Esophageal Squamous Cell Carcinoma Presenting with Multiple Bony Osteolytic Lesions Clinically Mimicking Multiple Myeloma: A Diagnostic Dilemma

2020 ◽  
Vol 12 (01) ◽  
pp. 76-78
Author(s):  
Bifica Sofia Lyngdoh ◽  
Biswajit Dey ◽  
Vandana Raphael ◽  
Iadarilang Tiewsoh
Keyword(s):  
Multiple Myeloma ◽  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Diagnostic Dilemma ◽  
Osteolytic Lesions ◽  
Diagnostic Work ◽  
Work Up ◽  
Diagnostic Work Up

AbstractBone metastasis as an initial presentation of esophageal carcinoma is uncommon. In the absence of typical presentations like dysphagia, these cases may lead to diagnostic dilemmas both for the clinicians and pathologists. Here, we report a case of disseminated metastasis of esophageal squamous cell carcinoma to the bone in a 47-year-old female, who presented with multiple osteolytic lesions and clinically mimicking multiple myeloma. A detailed diagnostic work-up established the diagnosis of esophageal squamous cell carcinoma.

The effects of the false vocal folds on laryngeal pressures and flows

2006 ◽  
Vol 120 (5) ◽  
pp. 3354-3354
Author(s):  
Li Sheng ◽  
Ronald C. Scherer ◽  
Wan MingXi ◽  
Wang SuPin ◽  
Qi LiYun
Keyword(s):  
Vocal Folds ◽  
False Vocal
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