scholarly journals Evolution of tRNA nucleotidyltransferases: A small deletion generated CC-adding enzymes

2008 ◽  
Vol 105 (23) ◽  
pp. 7953-7958 ◽  
Author(s):  
A. Neuenfeldt ◽  
A. Just ◽  
H. Betat ◽  
M. Morl
Keyword(s):  
Small Deletion

scholarly journals Small Deletion Variants Have Stable Breakpoints Commonly Associated with Alu Elements

PLoS ONE ◽  
2008 ◽  
Vol 3 (8) ◽  
pp. e3104 ◽  
Author(s):  
Adam J. de Smith ◽  
Robin G. Walters ◽  
Lachlan J. M. Coin ◽  
Israel Steinfeld ◽  
Zohar Yakhini ◽  
...  
Keyword(s):  
Alu Elements ◽  
Small Deletion

Small deletion in v-src SH3 domain of a transformation defective mutant of rous sarcoma virus restores wild type transforming properties

Virology ◽  
1992 ◽  
Vol 189 (2) ◽  
pp. 556-567 ◽  
Author(s):  
Philippe Dezélée ◽  
Jean Vianney Barnier ◽  
Annie Hampe ◽  
Danielle Laugier ◽  
Maria Marx ◽  
...  
Keyword(s):  
Rous Sarcoma Virus ◽  
Sh3 Domain ◽  
Wild Type ◽  
Small Deletion ◽  
Rous Sarcoma ◽  
Defective Mutant ◽  
Sarcoma Virus

Human c-fms proto-oncogene: comparative analysis with an abnormal allele

1985 ◽  
Vol 5 (2) ◽  
pp. 422-426
Author(s):  
J S Verbeek ◽  
A J Roebroek ◽  
A M van den Ouweland ◽  
H P Bloemers ◽  
W J Van de Ven
Keyword(s):  
Comparative Analysis ◽  
Dna Sequencing ◽  
Sequencing Analysis ◽  
Base Pairs ◽  
Small Deletion ◽  
Viral Oncogene ◽  
Close Proximity ◽  
Genetic Sequences ◽  
Dna Sequencing Analysis

The organization of the human c-fms proto-oncogene has been determined and compared with an abnormal allele. The human v-fms homologous genetic sequences are dispersed discontinuously and colinearly with the viral oncogene over a DNA region of ca. 32 kilobase pairs. The abnormal c-fms locus contains a small deletion in its 3' portion. DNA sequencing analysis indicated that it was 426 base pairs in size and located in close proximity to a putative c-fms exon.

scholarly journals Focal Xanthogranulomatous Pyelonephritis in Brachydactyly Mental Retardation Syndrome (2q37 Deletion Syndrome)

2019 ◽  
Vol 09 (02) ◽  
pp. 114-116
Author(s):  
Esra Nagehan Akyol Onder ◽  
Mine Ozkol ◽  
Nalan Nese ◽  
Can Taneli ◽  
Osman Orkun Cankorur ◽  
...  
Keyword(s):  
Mental Retardation ◽  
Renal Fibrosis ◽  
Granulomatous Inflammation ◽  
Rare Condition ◽  
Renal Parenchyma ◽  
Xanthogranulomatous Pyelonephritis ◽  
Deletion Syndrome ◽  
Inflammatory Infiltration ◽  
Small Deletion ◽  
Foamy Macrophages

AbstractXanthogranulomatous pyelonephritis (XGP) is characterized by destruction of the renal parenchyma and granulomatous inflammation with lipid-laden foamy macrophages as well as inflammatory infiltration and intensive renal fibrosis. It generally occurs in adults, especially those in the fifth and sixth decades of life, but is occasionally seen in children as well. Brachydactyly mental retardation (BDMR) syndrome (OMIM 600430) is caused by a small deletion of chromosome 2q37 and is a rare condition, with roughly 100 cases reported worldwide. Here, we describe the case of a patient with deletion of chromosome 2q37, which is known as the BDMR syndrome, and XGP.

scholarly journals Osteoarthritis-like lesions in transgenic mice harboring a small deletion mutation in type II collagen gene

2000 ◽  
Vol 8 (4) ◽  
pp. 248-257 ◽  
Author(s):  
A.-M.K Säämänen ◽  
H.J Salminen ◽  
P.B Dean ◽  
B De Crombrugghe ◽  
E.I Vuorio ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Type Ii Collagen ◽  
Deletion Mutation ◽  
Collagen Gene ◽  
Type Ii ◽  
Small Deletion

A small deletion in the olive fly acetylcholinesterase gene associated with high levels of organophosphate resistance

2008 ◽  
Vol 38 (8) ◽  
pp. 781-787 ◽  
Author(s):  
E.G. Kakani ◽  
I.M. Ioannides ◽  
J.T. Margaritopoulos ◽  
N.A. Seraphides ◽  
P.J. Skouras ◽  
...  
Keyword(s):  
Organophosphate Resistance ◽  
Small Deletion ◽  
Olive Fly ◽  
Acetylcholinesterase Gene

scholarly journals E. coli GyrA Tower Domain Interacts with QnrB1 Loop B and Plays an Important Role in QnrB1 Protection from Quinolone Inhibition

2021 ◽  
Author(s):  
Chunhui Chen ◽  
Yin Wang ◽  
Hidemasa Nakaminami ◽  
Eu Suk Kim ◽  
George A. Jacoby ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Amino Acids ◽  
Amino Acid ◽  
Dna Gyrase ◽  
Amino Acid Residues ◽  
Site Specific ◽  
E Coli ◽  
Small Deletion ◽  
Interaction Sites ◽  
Repeat Proteins

The Qnr pentapeptide repeat proteins interact with DNA gyrase and protect it from quinolone inhibition. The two external loops, particularly the larger loop B, of Qnr proteins are essential for quinolone protection of DNA gyrase. The specific QnrB1 interaction sites on DNA gyrase are not known. In this study, we investigated the interaction between GyrA and QnrB1 using site-specific photo crosslinking of QnrB1 loop B combined with mass spectrometry. We found that amino acid residues 286-298 on the Tower domain of GyrA interact with QnrB1 and play a key role in QnrB1 protection of gyrase from quinolone inhibition. Alanine replacement of arginine at residue 293 and a small deletion of amino acids 286-289 of GyrA resulted in a decrease in the QnrB1-mediated increase in quinolone MICs and also abolished the QnrB1 protection of purified DNA gyrase from ciprofloxacin inhibition.

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