scholarly journals A single antigen-specific B cell can conjugate to either a type 1 or a type 2 helper T cell.

1988 ◽  
Vol 85 (20) ◽  
pp. 7724-7728 ◽  
Author(s):  
V. M. Sanders ◽  
R. Fernandez-Botran ◽  
R. L. Coffman ◽  
T. R. Mosmann ◽  
E. S. Vitetta
Keyword(s):  
T Cell ◽  
B Cell ◽  
Helper T Cell ◽  
Single Antigen

Helper T-cell type 1 or type 2 function of xeno-MHC-restricted T-cell clones in a direct xenoantigen recognition

2003 ◽  
Vol 11 (2) ◽  
pp. 169-173 ◽  
Author(s):  
Yutaka Iida ◽  
Hisashi Iwata ◽  
Yoshio Mori ◽  
Hisato Takagi ◽  
Toyoo Nitta ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Type ◽  
Helper T Cell ◽  
T Cell Clones ◽  
Cell Clones

scholarly journals Establishment of an inbred line of mice that express a synergistic immune defect precluding in vitro responses to type 1 and type 2 antigens, B cell mitogens, and a number of T cell-derived helper factors.

1983 ◽  
Vol 158 (5) ◽  
pp. 1401-1414 ◽  
Author(s):  
J J Mond ◽  
G Norton ◽  
W E Paul ◽  
I Scher ◽  
F D Finkelman ◽  
...  
Keyword(s):  
T Cell ◽  
B Cells ◽  
B Cell ◽  
C3h Mice ◽  
Immune Defect ◽  
T Cell Help

Introduction of the CBA/N X-linked gene into C3H mice has resulted in the establishment of a new strain of mice that has profound immunologic defects. B cells from these mice show significantly impaired in vitro immune responses to the T cell-independent type 1 antigen trinitrophenyl-Brucella abortus (TNP-BA) as well as markedly reduced proliferative responses to a number of B cell mitogens when compared with the responses of the parental control mice. The in vivo response of such mice to TNP-BA is, however, comparable to that of CBA/N mice. Furthermore, B cells from C3.CBA/N mice are unresponsive to the plaque-forming cell enhancing effects induced by EL4-derived supernatant in the presence of TNP-BA, unlike B cells obtained from CBA/N or C3H/Hen mice whose responsiveness to TNP-BA can be significantly enhanced in the presence of EL4-derived supernatant. The model we have presented to best explain these results suggests that B cells from C3.CBA/N mice can be stimulated only under conditions in which they can interact with carrier-specific T cell help and not under conditions where factor-dependent responses are dominant.

Tea pigments inhibit the production of type 1 (TH1) and type 2 (TH2) helper T cell cytokines in CD4+ T cells

2002 ◽  
Vol 16 (1) ◽  
pp. 36-42 ◽  
Author(s):  
Michiyo Tomita ◽  
Kara I. Irwin ◽  
Zi-Jian Xie ◽  
Thomas J. Santoro
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cd4 T Cells ◽  
Helper T Cell

Effect of Diesel on Chemokines and Chemokine Receptors Involved in Helper T Cell Type 1/Type 2 Recruitment in Patients with Asthma

2003 ◽  
Vol 168 (2) ◽  
pp. 215-221 ◽  
Author(s):  
Stéphanie Sénéchal ◽  
Patricia de Nadai ◽  
Natacha Ralainirina ◽  
Arnaud Scherpereel ◽  
Han Vorng ◽  
...  
Keyword(s):  
T Cell ◽  
Chemokine Receptors ◽  
Cell Type ◽  
Helper T Cell

B-Cell Activation by Helper T-Cell Membranes

1994 ◽  
Vol 14 (3-4) ◽  
pp. 221-238 ◽  
Author(s):  
Marilyn R. Kehry ◽  
Philip D. Hodgkin
Keyword(s):  
T Cell ◽  
B Cell ◽  
Cell Membranes ◽  
Cell Activation ◽  
B Cell Activation ◽  
Helper T Cell

scholarly journals Enhanced T- and B-cell responses to simian immunodeficiency virus (SIV)agm, SIVmac and human immunodeficiency virus type 1 Gag DNA immunization and identification of novel T-cell epitopes in mice via codon optimization

2009 ◽  
Vol 90 (10) ◽  
pp. 2513-2518 ◽  
Author(s):  
Christine S. Siegismund ◽  
Oliver Hohn ◽  
Reinhard Kurth ◽  
Stephen Norley
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Cell ◽  
B Cell ◽  
Simian Immunodeficiency Virus ◽  
Codon Optimization ◽  
T Cell Epitopes ◽  
Gm Csf ◽  
Cell Responses ◽  
Immunodeficiency Virus

As a prelude to primate studies, the immunogenicity of wild-type and codon-optimized versions of simian immunodeficiency virus (SIV)agm Gag DNA, with and without co-administered granulocyte–macrophage colony-stimulating factor (GM-CSF) DNA, was directly compared in two strains of mice. Gag-specific T cells in the splenocytes of BALB/c and C57BL/6 mice immunized by gene gun were quantified by ELISpot using panels of overlapping synthetic peptides (15mers) spanning the entire capsid proteins of SIVagm, SIVmac and human immunodeficiency virus type 1. Specific antibodies were measured by ELISA. Codon optimization was shown to significantly increase the immune response to the DNA immunogens, reducing the amount of DNA necessary to induce cellular and antibody responses by one and two orders of magnitude, respectively. Co-administration of murine GM-CSF DNA was necessary for the induction of high level T- and B-cell responses. Finally, it was possible to identify both known and novel T-cell epitopes in the Gag proteins of the three viruses.

scholarly journals Follicular Helper T Cell Differentiation Requires Continuous Antigen Presentation that Is Independent of Unique B Cell Signaling

Immunity ◽  
2010 ◽  
Vol 33 (2) ◽  
pp. 241-253 ◽  
Author(s):  
Elissa K. Deenick ◽  
Anna Chan ◽  
Cindy S. Ma ◽  
Dominique Gatto ◽  
Pamela L. Schwartzberg ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
T Cell ◽  
Cell Signaling ◽  
B Cell ◽  
Antigen Presentation ◽  
T Cell Differentiation ◽  
Helper T Cell ◽  
B Cell Signaling ◽  
Follicular Helper ◽  
Follicular Helper T Cell
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