scholarly journals A Dominant Role of the Juxtamembrane Region of the TrkA Nerve Growth Factor Receptor during Neuronal Cell Differentiation

1997 ◽  
Vol 272 (37) ◽  
pp. 23231-23238 ◽  
Author(s):  
Sung Ok Yoon ◽  
Stephen P. Soltoff ◽  
Moses V. Chao
2003 ◽  
Vol 65 (9) ◽  
pp. 1507-1513 ◽  
Author(s):  
Takashi Takeuchi ◽  
John M Aletta ◽  
Suzanne G Laychock ◽  
Yingrao Tian ◽  
Ronald P Rubin

Nutrients ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1372
Author(s):  
Jin Gyu Choi ◽  
Zahra Khan ◽  
Seong Min Hong ◽  
Young Choong Kim ◽  
Myung Sook Oh ◽  
...  

Nerve growth factor (NGF), a typical neurotrophin, has been characterized by the regulation of neuronal cell differentiation and survival involved in learning and memory functions. NGF has a main role in neurite extension and synapse formation by activating the cyclic adenosine monophosphate-response-element-binding protein (CREB) in the hippocampus. The purpose of this study was to determine whether a mixture of Gotu Kola, Cnidium fruit, and Goji berry (KYJ) enhances memory function by inducing NGF-mediated actions both in vitro and in vivo. The KYJ combination increased NGF concentration and neurite length in C6 glioma and N2a neuronal cells, respectively. Additionally, we discovered memory-enhancing effects of KYJ through increased NGF-mediated synapse maturation, CREB phosphorylation, and cell differentiation in the mouse hippocampus. These findings suggest that this combination may be a potential nootropic cognitive enhancer via the induction of NGF and NGF-dependent activities.


2002 ◽  
Vol 295 (2) ◽  
pp. 324-329 ◽  
Author(s):  
Philip E Tarr ◽  
Cristina Contursi ◽  
Roberta Roncarati ◽  
Cristiana Noviello ◽  
Enrico Ghersi ◽  
...  

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