Involvement of nerve growth factor in mouse hippocampal neuronal cell line (HT22) differentiation and underlying role of DNA methyltransferases

2018 ◽  
Vol 81 (21) ◽  
pp. 1116-1122 ◽  
Author(s):  
Ming Zhang ◽  
Hongxia Zheng ◽  
Xiaolu Zhang ◽  
Xiaoli Tian ◽  
Shengdi Xu ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Cell Line ◽  
Neuronal Cell ◽  
Dna Methyltransferases ◽  
Nerve Growth ◽  
Neuronal Cell Line

Nerve Growth Factor Amplifies Cyclic AMP Production in the HT4 Neuronal Cell Line

2002 ◽  
Vol 64 (1) ◽  
pp. 220-228 ◽  
Author(s):  
Kelly A. Berg ◽  
Saul Maayani ◽  
Ronald McKay ◽  
William P. Clarke
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Cyclic Amp ◽  
Cell Line ◽  
Neuronal Cell ◽  
Nerve Growth ◽  
Neuronal Cell Line

scholarly journals The Role of Nerve Growth Factor (NGF) and Glial Cell Line‑Derived Neurotrophic Factor (GDNF) in Tic Disorders

2018 ◽  
Vol 34 (4) ◽  
Author(s):  
Ali Karayağmurlu ◽  
Hakan Öğütlü ◽  
İbrahim Selçuk Esin ◽  
Onur Burak Dursun ◽  
Ahmet Kızıltunç
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Cell Line ◽  
Glial Cell ◽  
Neurotrophic Factor ◽  
Tic Disorders ◽  
Nerve Growth

scholarly journals Pro-Nerve Growth Factor Induces Activation of RhoA Kinase and Neuronal Cell Death

2019 ◽  
Vol 9 (8) ◽  
pp. 204 ◽  
Author(s):  
Marina Sycheva ◽  
Jake Sustarich ◽  
Yuxian Zhang ◽  
Vaithinathan Selvaraju ◽  
Thangiah Geetha ◽  
...  
Keyword(s):  
Cell Death ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Kinase Activity ◽  
Kinase Inhibitor ◽  
Neuronal Cell Death ◽  
Rho Kinase ◽  
Neuronal Cell ◽  
Nerve Growth ◽  
Rhoa Kinase

We have previously shown that the expression of pro-nerve growth factor (proNGF) was significantly increased, nerve growth factor (NGF) level was decreased, and the expression of p75NTR was enhanced in Alzheimer’s disease (AD) hippocampal samples. NGF regulates cell survival and differentiation by binding TrkA and p75NTR receptors. ProNGF is the precursor form of NGF, binds to p75NTR, and induces cell apoptosis. The objective of this study is to determine whether the increased p75NTR expression in AD is due to the accumulation of proNGF and Rho kinase activation. PC12 cells were stimulated with either proNGF or NGF. Pull-down assay was carried out to determine the RhoA kinase activity. We found the expression of p75NTR was enhanced by proNGF compared to NGF. The proNGF stimulation also increased the RhoA kinase activity leading to apoptosis. The expression of active RhoA kinase was found to be increased in human AD hippocampus compared to control. The addition of RhoA kinase inhibitor Y27632 not only blocked the RhoA kinase activity but also reduced the expression of p75NTR receptor and inhibited the activation of JNK and MAPK induced by proNGF. This suggests that overexpression of proNGF in AD enhances p75NTR expression and activation of RhoA, leading to neuronal cell death.

scholarly journals Role of Nerve Growth Factor in Development and Persistence of Experimental Pulmonary Hypertension

2015 ◽  
Vol 192 (3) ◽  
pp. 342-355 ◽  
Author(s):  
Véronique Freund-Michel ◽  
Marcelina Cardoso Dos Santos ◽  
Christophe Guignabert ◽  
David Montani ◽  
Carole Phan ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Nerve Growth
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