scholarly journals Post-transcriptional Regulation of Sterol Regulatory Element-binding Protein-1 by Ethanol Induces Class I Alcohol Dehydrogenase in Rat Liver

2004 ◽  
Vol 279 (27) ◽  
pp. 28113-28121 ◽  
Author(s):  
Ling He ◽  
Frank A. Simmen ◽  
Martin J. J. Ronis ◽  
Thomas M. Badger
Keyword(s):  
Transcriptional Regulation ◽  
Alcohol Dehydrogenase ◽  
Rat Liver ◽  
Binding Protein ◽  
Regulatory Element ◽  
Class I ◽  
Element Binding Protein ◽  
Sterol Regulatory Element ◽  
Post Transcriptional Regulation

scholarly journals Sterol-dependent Transcriptional Regulation of Sterol Regulatory Element-binding Protein-2

1996 ◽  
Vol 271 (43) ◽  
pp. 26461-26464 ◽  
Author(s):  
Ryuichiro Sato ◽  
Jun Inoue ◽  
Yoshiki Kawabe ◽  
Tatsuhiko Kodama ◽  
Tatsuya Takano ◽  
...  
Keyword(s):  
Transcriptional Regulation ◽  
Binding Protein ◽  
Regulatory Element ◽  
Element Binding Protein ◽  
Sterol Regulatory Element

scholarly journals Thermally Oxidized Oil Increases the Expression of Insulin-Induced Genes and Inhibits Activation of Sterol Regulatory Element-Binding Protein-2 in Rat Liver

2007 ◽  
Vol 137 (9) ◽  
pp. 2018-2023 ◽  
Author(s):  
Alexander Koch ◽  
Bettina König ◽  
Julia Spielmann ◽  
Andrea Leitner ◽  
Gabriele I. Stangl ◽  
...  
Keyword(s):  
Rat Liver ◽  
Binding Protein ◽  
Regulatory Element ◽  
Oxidized Oil ◽  
Element Binding Protein ◽  
Sterol Regulatory Element ◽  
Induced Genes

scholarly journals Hairpin Orientation of Sterol Regulatory Element-binding Protein-2 in Cell Membranes as Determined by Protease Protection

1995 ◽  
Vol 270 (49) ◽  
pp. 29422-29427 ◽  
Author(s):  
Xianxin Hua ◽  
Juro Sakai ◽  
Ho Y. K. ◽  
Joseph L. Goldstein ◽  
Michael S. Brown
Keyword(s):  
Cell Membranes ◽  
Binding Protein ◽  
Regulatory Element ◽  
Element Binding Protein ◽  
Sterol Regulatory Element

scholarly journals Sterol Regulatory Element Binding Protein 1a Regulates Hepatic Fatty Acid Partitioning by Activating Acetyl Coenzyme A Carboxylase 2

2009 ◽  
Vol 29 (17) ◽  
pp. 4864-4872 ◽  
Author(s):  
Seung-Soon Im ◽  
Linda E. Hammond ◽  
Leyla Yousef ◽  
Cherryl Nugas-Selby ◽  
Dong-Ju Shin ◽  
...  
Keyword(s):  
Insertional Mutagenesis ◽  
Coenzyme A ◽  
Binding Protein ◽  
Regulatory Element ◽  
Fatty Acyl ◽  
Acetyl Coenzyme A ◽  
Acetyl Coenzyme ◽  
Element Binding Protein ◽  
Sterol Regulatory Element ◽  
Microarray Expression

ABSTRACT We generated a line of mice in which sterol regulatory element binding protein 1a (SREBP-1a) was specifically inactivated by insertional mutagenesis. Homozygous mutant mice were completely viable despite expressing SREBP-1a mRNA below 5% of normal, and there were minimal effects on expression of either SREBP-1c or -2. Microarray expression studies in liver, where SREBP-1a mRNA is 1/10 the level of the highly similar SREBP-1c, demonstrated that only a few genes were affected. The only downregulated genes directly linked to lipid metabolism were Srebf1 (which encodes SREBP-1) and Acacb (which encodes acetyl coenzyme A [acetyl-CoA] carboxylase 2 [ACC2], a critical regulator of fatty acyl-CoA partitioning between cytosol and mitochondria). ACC2 regulation is particularly important during food restriction. Similar to Acacb knockout mice, SREBP-1a-deficient mice have lower hepatic triglycerides and higher serum ketones during fasting than wild-type mice. SREBP-1a and -1c have identical DNA binding and dimerization domains; thus, the failure of the more abundant SREBP-1c to substitute for activating hepatic ACC2 must relate to more efficient recruitment of transcriptional coactivators to the more potent SREBP-1a activation domain. Our chromatin immunoprecipitation results support this hypothesis.

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