scholarly journals Proteomics of Mouse BRCA1-deficient Mammary Tumors Identifies DNA Repair Proteins with Potential Diagnostic and Prognostic Value in Human Breast Cancer

2012 ◽  
Vol 11 (7) ◽  
pp. M111.013334 ◽  
Author(s):  
Marc Warmoes ◽  
Janneke E. Jaspers ◽  
Thang V. Pham ◽  
Sander R. Piersma ◽  
Gideon Oudgenoeg ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Repair ◽  
Human Breast Cancer ◽  
Prognostic Value ◽  
Mammary Tumors ◽  
Human Breast ◽  
Dna Repair Proteins ◽  
Diagnostic And Prognostic Value

Abstract 5109: Proteomics of murine BRCA1 deficient breast tumors identifies DNA repair proteins with prognostic value in human breast cancer

2011 ◽  
Author(s):  
Marc O. Warmoes ◽  
Janneke Jaspers ◽  
Maarten P.G. Massink ◽  
Thang Pham ◽  
Sander R. Piersma ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Repair ◽  
Human Breast Cancer ◽  
Prognostic Value ◽  
Breast Tumors ◽  
Human Breast ◽  
Dna Repair Proteins

Serial Transplants of DMBA-Induced Mammary Tumors in Fischer Rats as Model System for Human Breast Cancer

Oncology ◽  
1995 ◽  
Vol 52 (4) ◽  
pp. 278-283 ◽  
Author(s):  
Christian Bartsch ◽  
Hella Bartsch ◽  
Anita Buchberger ◽  
Hartmut Rokos ◽  
Dieter Mecke ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Mammary Tumors ◽  
Model System ◽  
Human Breast ◽  
Fischer Rats

Enterolactone: A novel radiosensitizer for human breast cancer cell lines through impaired DNA repair and increased apoptosis

2016 ◽  
Vol 313 ◽  
pp. 180-194 ◽  
Author(s):  
Bahareh Bigdeli ◽  
Bahram Goliaei ◽  
Nastaran Masoudi-Khoram ◽  
Najmeh Jooyan ◽  
Alireza Nikoofar ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Repair ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Human Breast Cancer ◽  
Cancer Cell Lines ◽  
Human Breast Cancer Cell ◽  
Breast Cancer Cell Lines ◽  
Human Breast

scholarly journals Low E2F2 activity is associated with high genomic instability and PARPi resistance

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Jonathan P. Rennhack ◽  
Eran R. Andrechek
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Cell Cycle ◽  
Dna Repair ◽  
Human Breast Cancer ◽  
Metabolic Reprogramming ◽  
Patient Treatment ◽  
Expression Data ◽  
Human Breast

Abstract The E2F family, classically known for a central role in cell cycle, has a number of emerging roles in cancer including angiogenesis, metabolic reprogramming, metastasis and DNA repair. E2F1 specifically has been shown to be a critical mediator of DNA repair; however, little is known about DNA repair and other E2F family members. Here we present an integrative bioinformatic and high throughput drug screening study to define the role of E2F2 in maintaining genomic integrity in breast cancer. We utilized in vitro E2F2 ChIP-chip and over expression data to identify transcriptional targets of E2F2. This data was integrated with gene expression from E2F2 knockout tumors in an MMTV-Neu background. Finally, this data was compared to human datasets to identify conserved roles of E2F2 in human breast cancer through the TCGA breast cancer, Cancer Cell Line Encyclopedia, and CancerRx datasets. Through these methods we predict that E2F2 transcriptionally regulates mediators of DNA repair. Our gene expression data supports this hypothesis and low E2F2 activity is associated with a highly unstable tumor. In human breast cancer E2F2, status was also correlated with a patient’s response to PARP inhibition therapy. Taken together this manuscript defines a novel role of E2F2 in cancer progression beyond cell cycle and could impact patient treatment.

scholarly journals Use of a Polyclonal Antibody for the Determination of the Prognostic Value of c-erbB-2 Protein Over-Expression in Human Breast Cancer

1996 ◽  
Vol 35 (1) ◽  
pp. 23-30 ◽  
Author(s):  
Philippe Terrier ◽  
Hélène Mouriesse ◽  
Brigitte Loridon ◽  
Marianne Gotteland ◽  
Françoise May-Levin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Polyclonal Antibody ◽  
Human Breast Cancer ◽  
Prognostic Value ◽  
Human Breast ◽  
Over Expression
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