Clinical Utility of the Normative Studies Research Project Test Battery Among Vascular Dementia Patients

2000 ◽  
Vol 14 (2) ◽  
pp. 173-180 ◽  
Author(s):  
Benjamin T. Mast ◽  
Susan E. MacNeill ◽  
Peter A. Lichtenberg
Keyword(s):  
Vascular Dementia ◽  
Clinical Utility ◽  
Test Battery ◽  
Research Project ◽  
Dementia Patients

scholarly journals Classifying Non-Dementia and Alzheimer’s Disease/Vascular Dementia Patients Using Kinematic, Time-Based, and Visuospatial Parameters: The Digital Clock Drawing Test

2021 ◽  
Vol 82 (1) ◽  
pp. 47-57 ◽  
Author(s):  
Anis Davoudi ◽  
Catherine Dion ◽  
Shawna Amini ◽  
Patrick J. Tighe ◽  
Catherine C. Price ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Vascular Dementia ◽  
Area Under The Curve ◽  
Clock Drawing Test ◽  
Digital Clock ◽  
Clock Drawing ◽  
Drawing Test ◽  
Dementia Patients ◽  
Optimal Area

Background: Advantages of digital clock drawing metrics for dementia subtype classification needs examination. Objective: To assess how well kinematic, time-based, and visuospatial features extracted from the digital Clock Drawing Test (dCDT) can classify a combined group of Alzheimer’s disease/Vascular Dementia patients versus healthy controls (HC), and classify dementia patients with Alzheimer’s disease (AD) versus vascular dementia (VaD). Methods: Healthy, community-dwelling control participants (n = 175), patients diagnosed clinically with Alzheimer’s disease (n = 29), and vascular dementia (n = 27) completed the dCDT to command and copy clock drawing conditions. Thirty-seven dCDT command and 37 copy dCDT features were extracted and used with Random Forest classification models. Results: When HC participants were compared to participants with dementia, optimal area under the curve was achieved using models that combined both command and copy dCDT features (AUC = 91.52%). Similarly, when AD versus VaD participants were compared, optimal area under the curve was, achieved with models that combined both command and copy features (AUC = 76.94%). Subsequent follow-up analyses of a corpus of 10 variables of interest determined using a Gini Index found that groups could be dissociated based on kinematic, time-based, and visuospatial features. Conclusion: The dCDT is able to operationally define graphomotor output that cannot be measured using traditional paper and pencil test administration in older health controls and participants with dementia. These data suggest that kinematic, time-based, and visuospatial behavior obtained using the dCDT may provide additional neurocognitive biomarkers that may be able to identify and tract dementia syndromes.

A Study on the Influence of Cysteine and Magnesium Ions on Brain Dementia

2014 ◽  
Vol 487 ◽  
pp. 161-164
Author(s):  
Lu Yin ◽  
Shuang Yue Zhu
Keyword(s):  
Vascular Dementia ◽  
Plasma Homocysteine ◽  
Diagnosis And Treatment ◽  
Magnesium Ion ◽  
Disease Development ◽  
Mechanism Analysis ◽  
Magnesium Ions ◽  
Patients Âgés ◽  
Dementia Patients ◽  
Relationship Of

As the population ages, dementia disease is increasingly becoming the most concerned social problems. According to the cause of dementia, it can be divided into many kinds class, among them with Alzheimer's Disease (Alzheimers diseases, AD) and Vascular Dementia (Vascular Dementia, VD) are common. Data shows it accounts for nearly 60% of total AD dementia patients, VD (20%), but only 2% of patients could get timely diagnosis and treatment, make its cognitive damage to a certain extent suppress and improve. for untimely diagnosis and treatment, most patients makes the disease development worse. In recent years, studies have shown that plasma Homocysteine,Hcy levels associated with AD. And studies show that from the power of the risk factors to the mechanism analysis, dementia disease level correlation with magnesium ions. On this basis, this study of plasma homocysteine in patients with AD,VD and magnesium ion detection results were analyzed retrospectively. Discuss their levels between the distributio relationship of patients ages in AD and VD.

scholarly journals Etiological Pattern of Dementia in Bangladesh

2016 ◽  
Vol 32 (2) ◽  
pp. 85-90
Author(s):  
MRK Khan ◽  
AN Rizvi ◽  
MA Habib ◽  
MK Hasan ◽  
A Mamun ◽  
...  
Keyword(s):  
Vascular Dementia ◽  
Neurodegenerative Disorder ◽  
Psychosocial Interventions ◽  
Cross Sectional Study ◽  
Chronic Subdural Haematoma ◽  
Cross Sectional ◽  
Dementia Patients ◽  
Dsm Iv ◽  
Medical University ◽  
State Examination

Background: Dementia is a chronic & progressive neurodegenerative disorder affecting usually older people of more than 65 years in which there are disturbances of multiple higher cortical functions including memory, thinking, orientation & others. Dementia patients are increasing in number as the population of older age group is increasing. All types of dementia are treatable, at least with psychosocial interventions. So, accurate diagnosis and evaluation of etiological pattern is essential. Methods: This cross sectional study was carried out in the Department of Neurology, Bangabandu Sheikh Mujib Medical University, Dhaka, Bangladesh from January 2012 to December 2012 on 88 patients with dementia diagnosed on the basis of mini mental state examination and DSM-IV criteria. Results: Vascular dementia was the underlying diagnosis in most of the cases (43.3 %) followed by Alzheimers Disease (20.2%) and Parkinson Disease (9%). Other causes were Mixed Dementia, Intracranial Space Occupying Lesion, Post Encephalitic, Hypoxic Encephalitic, Chronic Subdural Haematoma and Tubercular Meningitis. Conclusion: Vascular dementia is more than Alzheimer’s Dementia in Bangladesh. Multiple vascular risk factors contribute to this. Bangladesh Journal of Neuroscience 2016; Vol. 32 (2): 85-90

scholarly journals Spectrum-specific encephalography standardized low-resolution brain electromagnetic tomography network and gray matter correlations in vascular dementia patients

2020 ◽  
Vol 16 (1) ◽  
pp. 155014771989596
Author(s):  
Yan Lv ◽  
Huijuan Chen ◽  
Zhiyan Sui ◽  
Yingliu Huang ◽  
Shixiong Huang ◽  
...  
Keyword(s):  
Vascular Dementia ◽  
Topological Analysis ◽  
Cognitive Disorder ◽  
Voxel Based Morphometry ◽  
Low Resolution ◽  
Mild Dementia ◽  
Electromagnetic Tomography ◽  
Brain Electromagnetic ◽  
Dementia Patients ◽  
Tomography Analysis

Vascular dementia, secondary to Alzheimer’s dementia, ranks as one of the most frequent dementia types. The process of vascular dementia is divergent with other neurodegenerative dementias and thus reversible at the early cognitive disorder or mild dementia stages. The encephalography and neuroimaging data mining at different stages would bring neuromodulation strategies in practice; 15 mild cognitive impairment patients and 16 mild vascular dementia patients as well as 17 cognitive healthy controls were screened in this study. Cognitive tests such as Mini-Mental State Examination, Montreal cognitive assessment, voxel-based morphometry, electroencephalography, and standardized low-resolution brain electromagnetic tomography connectivity network were conducted. Compared with healthy group, voxel-based morphometry analysis showed a decrease in gray/cerebrospinal fluid ratio ( p < .05) in mild dementia group; the energy power of gamma band decreased ( p < .05) in mild dementia group; and electroencephalography standardized low-resolution brain electromagnetic tomography analysis showed wider frontal and temporal lobe involvement in mild dementia patients ( p < .05). Network topological analysis screened top 10 key Brodmann areas (44R, 7R, 8L, 22L, 47L, 27L, 1L, 1R, 7R, 43L), which could be underlying neuromodulators for dementia patients. Electroencephalography as well as structural magnetic resonance imaging could be used for the evaluation of cognitive disorder patients. The spectrum-specific standardized low-resolution brain electromagnetic tomography analysis and connectivity network analysis could shed light on the neuromodulator targets in the early phase of dementia.

Long-lived picture priming in normal elderly persons and demented patients

1998 ◽  
Vol 4 (4) ◽  
pp. 336-341 ◽  
Author(s):  
WILLIAM W. BEATTY ◽  
SHELLEY ENGLISH ◽  
PETER WINN
Keyword(s):  
Alzheimer’S Disease ◽  
Vascular Dementia ◽  
Explicit Memory ◽  
Elderly Persons ◽  
Short Term ◽  
Memory Functions ◽  
Dementia Patients ◽  
Normal Elderly Control ◽  
Elderly Control

Normal elderly control participants showed short-term (10-min delay) and long-term (12 months delay) priming on the Gollin Figures Test. Nearly all patients with Alzheimer's disease or vascular dementia showed short-term priming, but the magnitude of their priming was less than that of controls. Significant long-term priming was not observed for the dementia groups. Differences between controls and dementia patients on the short-term priming test may depend upon structural–perceptual processes that are intact in dementia patients and controls and explicit memory functions available only to controls. The same model could account for differences between normal elderly and dementia patients on the long-term priming test, but several other explanations are also plausible. (JINS, 1998, 4, 336–341.)

Neuropsychological Performance in Both Alzheimer’s Disease and Vascular Dementia is Related to Cardiovascular Comorbidity

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
N. Hofrichter ◽  
S. Dick ◽  
E. Tritschler ◽  
A. Knobel ◽  
A. Heinz ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Working Memory ◽  
Vascular Dementia ◽  
Neuropsychological Testing ◽  
Vascular Pathology ◽  
Neuropsychological Performance ◽  
Neuropsychological Battery ◽  
Cardiovascular Comorbidity ◽  
Dementia Patients

Aims:Vascular pathology has been implicated in the pathogenesis of both Alzheimer's disease and vascular dementia. While performance decrements in vascular dementia are by definition thought to be related to vascular load, performance decrements in Alzheimer's disease have not yet been studied in relationship to cardiovascular comorbidity. The aim of this study was to describe neuropsychological performance in patients with mild Alzheimer's disease and vascular dementia in relationship to cardiovascular comorbidity.Method:39 patients suffering form vascular dementia and 34 patients suffering form Alzheimer's disease underwent neuropsychological testing using an extended neuropsychological battery, including tests of episodic memory, working memory, naming, verbal fluency, executive functions, and language. Cardiovascular comorbidity was assessed form medical history and chart review using the Charlson comorbidity index.Results:Patients suffering form Alzheimer's disease and vascular dementia did not differ in terms of age, education, gender distribution, or dementia severity. Cardiovascular comorbidty was more pronounced in vascular dementia patients. In both Alzheimer's disease and vascular dementia, neuropsychological performance in tests of working memory and executive functioning was related to cardiovascular comorbidity, but the relationship was stronger in vascular dementia.Conclusion:Vascular load affects neuropsychological performance in both Alzheimer's disease and vascular dementia, suggesting that cardiovascular comorbidity affects cognition across both forms of dementia.

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