A Study on the Influence of Cysteine and Magnesium Ions on Brain Dementia

2014 ◽  
Vol 487 ◽  
pp. 161-164
Author(s):  
Lu Yin ◽  
Shuang Yue Zhu
Keyword(s):  
Vascular Dementia ◽  
Plasma Homocysteine ◽  
Diagnosis And Treatment ◽  
Magnesium Ion ◽  
Disease Development ◽  
Mechanism Analysis ◽  
Magnesium Ions ◽  
Patients Âgés ◽  
Dementia Patients ◽  
Relationship Of

As the population ages, dementia disease is increasingly becoming the most concerned social problems. According to the cause of dementia, it can be divided into many kinds class, among them with Alzheimer's Disease (Alzheimers diseases, AD) and Vascular Dementia (Vascular Dementia, VD) are common. Data shows it accounts for nearly 60% of total AD dementia patients, VD (20%), but only 2% of patients could get timely diagnosis and treatment, make its cognitive damage to a certain extent suppress and improve. for untimely diagnosis and treatment, most patients makes the disease development worse. In recent years, studies have shown that plasma Homocysteine,Hcy levels associated with AD. And studies show that from the power of the risk factors to the mechanism analysis, dementia disease level correlation with magnesium ions. On this basis, this study of plasma homocysteine in patients with AD,VD and magnesium ion detection results were analyzed retrospectively. Discuss their levels between the distributio relationship of patients ages in AD and VD.

scholarly journals Classifying Non-Dementia and Alzheimer’s Disease/Vascular Dementia Patients Using Kinematic, Time-Based, and Visuospatial Parameters: The Digital Clock Drawing Test

2021 ◽  
Vol 82 (1) ◽  
pp. 47-57 ◽  
Author(s):  
Anis Davoudi ◽  
Catherine Dion ◽  
Shawna Amini ◽  
Patrick J. Tighe ◽  
Catherine C. Price ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Vascular Dementia ◽  
Area Under The Curve ◽  
Clock Drawing Test ◽  
Digital Clock ◽  
Clock Drawing ◽  
Drawing Test ◽  
Dementia Patients ◽  
Optimal Area

Background: Advantages of digital clock drawing metrics for dementia subtype classification needs examination. Objective: To assess how well kinematic, time-based, and visuospatial features extracted from the digital Clock Drawing Test (dCDT) can classify a combined group of Alzheimer’s disease/Vascular Dementia patients versus healthy controls (HC), and classify dementia patients with Alzheimer’s disease (AD) versus vascular dementia (VaD). Methods: Healthy, community-dwelling control participants (n = 175), patients diagnosed clinically with Alzheimer’s disease (n = 29), and vascular dementia (n = 27) completed the dCDT to command and copy clock drawing conditions. Thirty-seven dCDT command and 37 copy dCDT features were extracted and used with Random Forest classification models. Results: When HC participants were compared to participants with dementia, optimal area under the curve was achieved using models that combined both command and copy dCDT features (AUC = 91.52%). Similarly, when AD versus VaD participants were compared, optimal area under the curve was, achieved with models that combined both command and copy features (AUC = 76.94%). Subsequent follow-up analyses of a corpus of 10 variables of interest determined using a Gini Index found that groups could be dissociated based on kinematic, time-based, and visuospatial features. Conclusion: The dCDT is able to operationally define graphomotor output that cannot be measured using traditional paper and pencil test administration in older health controls and participants with dementia. These data suggest that kinematic, time-based, and visuospatial behavior obtained using the dCDT may provide additional neurocognitive biomarkers that may be able to identify and tract dementia syndromes.

scholarly journals Etiological Pattern of Dementia in Bangladesh

2016 ◽  
Vol 32 (2) ◽  
pp. 85-90
Author(s):  
MRK Khan ◽  
AN Rizvi ◽  
MA Habib ◽  
MK Hasan ◽  
A Mamun ◽  
...  
Keyword(s):  
Vascular Dementia ◽  
Neurodegenerative Disorder ◽  
Psychosocial Interventions ◽  
Cross Sectional Study ◽  
Chronic Subdural Haematoma ◽  
Cross Sectional ◽  
Dementia Patients ◽  
Dsm Iv ◽  
Medical University ◽  
State Examination

Background: Dementia is a chronic & progressive neurodegenerative disorder affecting usually older people of more than 65 years in which there are disturbances of multiple higher cortical functions including memory, thinking, orientation & others. Dementia patients are increasing in number as the population of older age group is increasing. All types of dementia are treatable, at least with psychosocial interventions. So, accurate diagnosis and evaluation of etiological pattern is essential. Methods: This cross sectional study was carried out in the Department of Neurology, Bangabandu Sheikh Mujib Medical University, Dhaka, Bangladesh from January 2012 to December 2012 on 88 patients with dementia diagnosed on the basis of mini mental state examination and DSM-IV criteria. Results: Vascular dementia was the underlying diagnosis in most of the cases (43.3 %) followed by Alzheimers Disease (20.2%) and Parkinson Disease (9%). Other causes were Mixed Dementia, Intracranial Space Occupying Lesion, Post Encephalitic, Hypoxic Encephalitic, Chronic Subdural Haematoma and Tubercular Meningitis. Conclusion: Vascular dementia is more than Alzheimer’s Dementia in Bangladesh. Multiple vascular risk factors contribute to this. Bangladesh Journal of Neuroscience 2016; Vol. 32 (2): 85-90

scholarly journals Activation of brain hexokinase by magnesium ions and by magnesium ion–adenosine triphosphate complex

1972 ◽  
Vol 130 (1) ◽  
pp. 63-69 ◽  
Author(s):  
Daniel L. Purich ◽  
Herbert J. Fromm
Keyword(s):  
Simple Model ◽  
Complex Formation ◽  
Kinetic Data ◽  
Alternative Explanation ◽  
Metal Substrate ◽  
Magnesium Ion ◽  
Magnesium Ions ◽  
Substrate Complex ◽  
The Brain ◽  
Hill Plots

1. An alternative explanation for the kinetic data obtained by Bachelard (1971) for the brain hexokinase reaction is presented. 2. Apparently sigmoidal saturation curves for MgATP2− based upon Bachelard's (1971) studies can be corrected to hyperbolic curves by use of a stability constant for MgATP2− complex formation. 3. A number of other effects related to the concentration-dependent stability of the MgATP2− complex and to the presence of the inhibitory free uncomplexed ATP4− concentration are also explained in terms of a non-allosteric role for either Mg2+ or MgATP2− fully consistent with a number of previous reports on this enzyme. 4. A brief discussion of the validity of Hill plots in studies of multisubstrate co-operative enzymes is presented. 5. A simple model is presented that demonstrates how enzymes obeying Michaelis–Menten kinetics can demonstrate sigmoidal velocity responses if the true substrate of the reaction is the metal–substrate complex.

EDUCATION

PEDIATRICS ◽  
1954 ◽  
Vol 14 (5) ◽  
pp. 547-556
Author(s):  
ALBERT J. SOLNIT ◽  
MILTON J. E. SENN
Keyword(s):  
Active Role ◽  
Diagnosis And Treatment ◽  
Community Resources ◽  
Social Forces ◽  
Professional Identification ◽  
Parental Figures ◽  
Healthy Growth ◽  
Effective Diagnosis ◽  
Relationship Of ◽  
The Relationship

1. The out-patient clinic is the most valuable place for the physician to learn how comprehensive pediatrics can be mastered in his every-day office and home-visit practice. It is also the logical place to teach the relationship of community resources to pediatric practice. 2. Comprehensive medical care of the child is defined as the prevention and treatment of physical disease, and the supervision of healthy growth and development, physical and psychological. Through his comprehension of physical, psychological and social forces that influence the child, the pediatrician enables the child and his family to take an active role in solving their health problem. 3. The interview should serve as a basic instrument of diagnosis and treatment. It should be flexible, and enable the patient to express fears, anticipations and questions about his symptoms. It should be practical in length of time and sequence, depending on the patient's symptoms and his reactions to being examined by the doctor. 4. The attitudes necessary for the practice of pediatrics are best acquired by the student through the demonstrations of his teachers and through his professional identification with them. 5. When pediatric teaching is focussed on the patient as a person, a student learns that: a) Every patient is an interesting person. It can be as satisfying and important to care for a six-week-old infant who is well or a child who is going to camp, as one who suffers from a rare disease. b) There is no such thing as a non-contributory family history. It is necessary to know the meaning that complaints or questions have for the mother and the child. This can only be obtained through the physician's expressed interest in both, and in his patient attitude and willingness to listen to what both have to tell him. c) The physician is faced with a patient (child) who is extremely dependent on parents or parental figures. The parents and child form a unit. It is the pediatrician's goal to help improve the health of the child by understanding the child's position in the unit. He should utilize the assets of this unit for the child and parents. d) His interest in and acceptance of the patient results in more effective diagnosis and treatment. This attitude develops gradually when adequate supervision is available.

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