Pharmacokinetics and metabolic disposition of a potent and selective kynurenine monooxygenase inhibitor, CHDI-340246, in laboratory animals

Anesthesia for laboratory animals is a matter of biomedical concern and one of the most present dilemmas in the current bioethical debate. The use of anesthetic agents in experimental surgery aims at analgesia and restraining the animal, in order to achieve a reasonable degree of muscle relaxation and to produce sufficient analgesia. This practice requires the use of protocols for the administration of safe and efficient doses. Eight New Zealand rabbits were submitted to laparotomies demonstrating the surgical technique discipline of the local medical course. For pre-anesthetic medication, acepromazine 1 mg.kg-1 associated with ketamine 15 mg.kg-1 was used subcutaneously. Anesthesia was maintained with isoflurane and oxygen under a laryngeal mask in a Mapleson D anesthesia system and under spontaneous breathing. Hydration was performed with 10 ml.kg-1 saline every hour. A thermal mattress was used. Precordial stethoscope, pulse oximetry and clinical parameters were used for monitoring. For euthanasia, ketamine 10 mg.kg-1 associated with potassium chloride 19.1% 1 ml.kg-1 was used intravenously. The average weight of the rabbits was 2721.25 ± 275.01 grams and the duration of the anesthetic procedure was 120 ± 87 minutes. Discussion. In long-term anesthesia, such as laparotomies, the use of pre-anesthetic medication and then anesthetic induction by the combination of agents is recommended. However, anesthetic management requires monitoring to prevent insufficient or excessive doses from occurring.

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Efficacy of praziquantel (Cesocide® injection) in treatment of cestode infections in domestic and laboratory animals

The Korean Journal of Parasitology ◽

10.3347/kjp.1988.26.2.121 ◽

1988 ◽

Vol 26 (2) ◽

pp. 121 ◽

Cited By ~ 6

Author(s):

Kee Seon Eom ◽

Seung Ho Kim ◽

Han Jong Rim

Keyword(s):

Laboratory Animals

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B-cell and T-cell values in peripheral blood in Polish mixed-breed rabbits with addition of blood of meet breeds

Polish Journal of Veterinary Sciences ◽

10.2478/pjvs-2014-0060 ◽

2014 ◽

Vol 17 (3) ◽

pp. 421-426 ◽

Cited By ~ 1

Author(s):

B. Tokarz-Deptuła ◽

P. Niedźwiedzka-Rystwej ◽

B. Hukowska-Szematowicz ◽

M. Adamiak ◽

A. Trzeciak-Ryczek ◽

...

Keyword(s):

T Cells ◽

B Cells ◽

B Cell ◽

Cd8 T Cells ◽

Peripheral Blood ◽

Laboratory Animals ◽

Immunological Parameters ◽

Four Seasons ◽

Mixed Breed ◽

The Impact

Abstract In Poland, rabbit is a highly valued animal, due to dietetic and flavour values of its meat, but above all, rabbits tend to be commonly used laboratory animals. The aim of the study was developing standards for counts of B-cells with CD19+ receptor, T-cells with CD5+ receptor, and their subpopulations, namely T-cells with CD4+, CD8+ and CD25+ receptor in the peripheral blood of mixed-breed Polish rabbits with addition of blood of meet breeds, including the assessment of the impact of four seasons of the year and animal sex on the values of the immunological parameters determined. The results showed that the counts of B- and T-cells and their subpopulations in peripheral blood remain within the following ranges: for CD19+ B-cells: 1.05 - 3.05%, for CD5+ T-cells: 34.00 - 43.07%, CD4+ T-cells: 23.52 - 33.23%, CD8+ T-cells: 12.55 - 17.30%, whereas for CD25+ T-cells: 0.72 - 2.81%. As it comes to the season of the year, it was observed that it principally affects the values of CD25+ T-cells, while in the case of rabbit sex, more changes were found in females.

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Automation for improved physiological research in microgravity using laboratory animals

10.2514/6.1996-4326 ◽

1996 ◽

Author(s):

David Conrad ◽

John Emond ◽

Louis Stodieck

Keyword(s):

Laboratory Animals ◽

Physiological Research

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Calculations used for assessment of rapid maxillary expansion

ORL ro ◽

10.26416/orl.30.1.2016.525 ◽

2016 ◽

Vol 1 (1) ◽

pp. 24-26

Author(s):

Ruxandra Bartok ◽

Bogdan Dimitriu Dimitriu ◽

Constantin Vârlan ◽

Radu Stanciu ◽

Georgiana Moldoveanu ◽

...

Keyword(s):

Tensile Strength ◽

Elasticity Modulus ◽

Rapid Maxillary Expansion ◽

Laboratory Animals ◽

Maxillary Expansion ◽

Literature Reference ◽

Bone Changes ◽

Upper Jaw ◽

Materials Used

Rapid maxillary expansion is defined as the release of medio-palatine suture using an orthopedic forces. The role of this procedure is to expand the upper jaw in order to achieve the broadening of the upper arch. This study was initiated to quantify the effects of disjunction and post- treatment bone changes, after an adequate contention which lasted for three weeks. This study is carried on laboratory animals (common breed rabbit) to determine tensile strength and the elasticity modulus of biological materials used in orthdodontics. The results of the study are consistent with those reported in the literature reference.

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