Poly(ε-caprolactone) electrospun nanofibers containing curcumin nanocontainers: enhanced solubility, dissolution and physical stability of curcumin via formation of inclusion complex with cyclodextrins

2018 ◽  
Vol 68 (11) ◽  
pp. 669-679 ◽  
Author(s):  
Sahar Amiri ◽  
Azam Rahimi
Keyword(s):  
Inclusion Complex ◽  
Physical Stability ◽  
Electrospun Nanofibers ◽  
Enhanced Solubility

Influence of β-Cyclodextrin and Hydroxypropyl-β-Cyclodextrin on Enhancement of Solubility and Dissolution of Isradipine

2017 ◽  
Vol 10 (3) ◽  
pp. 3752-3757
Author(s):  
Narendar D ◽  
Ettireddy S
Keyword(s):  
Inclusion Complex ◽  
Dissolution Rate ◽  
Solid Dispersions ◽  
Physical Stability ◽  
Molecular Complexes ◽  
In Vitro Dissolution ◽  
Molar Ratio ◽  
Phase Solubility ◽  
Cyclodextrin Complexation

The content of this investigation was to study the influence of β-cyclodextrin and hydroxy propyl-β-cyclodextrin complexation on enhancement of solubility and dissolution rate of isradipine. Based on preliminary phase solubility studies, solid complexes prepared by freeze drying method in 1:1 molar ratio were selected and characterized by DSC for confirmation of complex formation. Prepared solid dispersions were evaluated for drug content, solubility and in vitro dissolution. The physical stability of optimized formulation was studied at refrigerated and room temperature for 2 months. Solid state characterization of optimized complex performed by DSC and XRD studies.  Dissolution rate of isradipine was increased compared with pure drug and more with HP-β-CD inclusion complex than β-CD. DSC and XRD analyzes that drug was in amorphous form, when the drug was incorporated as isradipine β-CD and HP-β-CD inclusion complex. Stability studies resulted in low or no variations in the percentage of complexation efficiency suggesting good stability of molecular complexes. The results conclusively demonstrated that the enhancement of solubility and dissolution rate of isradipine by drug-cyclodextrin complexation was achieved.   

scholarly journals Enhanced Solubility, Stability, and Herbicidal Activity of the Herbicide Diuron by Complex Formation with β-Cyclodextrin

Polymers ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 1396 ◽  
Author(s):  
Shuang Gao ◽  
Jing-Yu Jiang ◽  
Yan-Yan Liu ◽  
Ying Fu ◽  
Li-Xia Zhao ◽  
...  
Keyword(s):  
Inclusion Complex ◽  
1H Nmr ◽  
Water Solubility ◽  
Herbicidal Activity ◽  
Environmental Damage ◽  
Phase Solubility ◽  
Scanning Calorimetry ◽  
Enhanced Solubility ◽  
Phase Solubility Study ◽  
Herbicide Diuron

The herbicide diuron is hardly soluble in water and most organic solvents and is usually made into a wettable powder or mixed with soil when used, which causes environmental risk and a reduction in herbicidal efficacy. In this study, the physicochemical properties were changed by using β-cyclodextrin (β-CD) to encapsulate diuron to form an inclusion complex. Some key technologies, including X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and nuclear magnetic resonance (1H NMR), were used to characterize the inclusion complex. The stoichiometry of the inclusion complex was determined by recording the 1H NMR spectrum or by using a diagram of inclusion ratios. A phase solubility study proved that the formed inclusion complex exhibited higher water solubility. Thermogravimetric analysis (TGA) demonstrated that the formed inclusion complex exhibited better thermal stability. Biological activity studies indicated that the herbicidal activity, in terms of herbicide removal, of the formed inclusion complex was higher than that of the original diuron. In general, the formation of the inclusion complex could reduce the environmental damage caused by diuron and enhance its herbicidal activity, providing an environmentally friendly method for using diuron.

scholarly journals Discovery, Characterization, and Pharmaceutical Applications of Two Loratadine–Oxalic Acid Cocrystals

Crystals ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 996
Author(s):  
Zhengxuan Liang ◽  
Hongbo Chen ◽  
Chenguang Wang ◽  
Changquan Calvin Sun
Keyword(s):  
Oxalic Acid ◽  
Dissolution Rate ◽  
Physical Stability ◽  
Formulation Development ◽  
Intrinsic Dissolution ◽  
Intrinsic Dissolution Rate ◽  
Conjugate Acid ◽  
Enhanced Solubility ◽  
Antihistamine Drug ◽  
Low Solubility

Loratadine (Lor) is an antihistamine drug commonly used to relieve the symptoms of allergy. It has high permeability but low solubility under physiological conditions. To overcome the problem of low solubility, we synthesized and characterized two Loratadine multi-component crystalline phases with oxalic acid (Oxa), i.e., a 1:1 Lor-Oxa conjugate acid-base (CAB) cocrystal (Lor-Oxa CAB) and a 2:1 Lor-Oxa cocrystal monohydrate (Lor-Oxa hydrate). Both cocrystals exhibited an enhanced solubility and intrinsic dissolution rate (IDR) compared to Lor and adequate physical stability. The intrinsic dissolution rate of Lor-Oxa CAB is 95 times that of Lor, which makes it a promising candidate for tablet formulation development.

Sweet pharmaceutical salts of stanozolol with enhanced solubility and physical stability

CrystEngComm ◽  
2016 ◽  
Vol 18 (45) ◽  
pp. 8739-8746 ◽  
Author(s):  
Minmin Kong ◽  
Xue Fu ◽  
Jiaoyang Li ◽  
Jianhui Li ◽  
Minhua Chen ◽  
...  
Keyword(s):  
Physical Stability ◽  
Pharmaceutical Salts ◽  
Enhanced Solubility

Enhanced solubility, stability, permeation and anti-cancer efficacy of Celastrol-β-cyclodextrin inclusion complex

2020 ◽  
Vol 318 ◽  
pp. 113936 ◽  
Author(s):  
Snehal K. Shukla ◽  
Amanda Chan ◽  
Vineela Parvathaneni ◽  
Dipti D. Kanabar ◽  
Kinjal Patel ◽  
...  
Keyword(s):  
Inclusion Complex ◽  
Cyclodextrin Inclusion ◽  
Enhanced Solubility ◽  
Anti Cancer ◽  
Cyclodextrin Inclusion Complex

Development of Anacardic Acid/hydroxypropyl-β-cyclodextrin inclusion complex with enhanced solubility and antimicrobial activity

2019 ◽  
Vol 296 ◽  
pp. 112085 ◽  
Author(s):  
Md Meraj Anjum ◽  
Krishna Kumar Patel ◽  
Nidhi Pandey ◽  
Ragini Tilak ◽  
Ashish Kumar Agrawal ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Inclusion Complex ◽  
Anacardic Acid ◽  
Cyclodextrin Inclusion ◽  
Enhanced Solubility ◽  
Cyclodextrin Inclusion Complex

New Patent on Electrospinning for Increasing Rutin Loading in Nanofibers

2020 ◽  
Vol 14 (1) ◽  
pp. 35-41
Author(s):  
Na Li ◽  
Yongfang Qian ◽  
Zhen Zhang ◽  
Ying Wang ◽  
Lihua Lve ◽  
...  
Keyword(s):  
Fourier Transform ◽  
Inclusion Complex ◽  
Inclusion Complexes ◽  
Electrospun Nanofibers ◽  
Cyclodextrin Inclusion ◽  
Cyclodextrin Inclusion Complex ◽  
Loading Amount ◽  
Functional Nanofibers ◽  
Surface Morphologies ◽  
Scanning Electron

Background: The electrospinning and the bubble electrospinning provide facile ways for the fabrication of functional nanofibers by incorporating rutin/hydroxypropyl-β-cyclodextrin inclusion complex (RT/HP-β-CD-IC) in Polyvinyl Alcohol (PVA). Few patents on incorporation of rutin and cyclodextrin in nanofibers has been reported. Objective: The study aimed at increasing the loading amount of rutin in the electrospun nanofibers to obtain ultraviolet resistant property. Methods: Rutin was encapsulated in the cavity of RT/HP-β-CD and formed an inclusion complex. Fourier Transform Infrared Spectroscopy (FTIR) and Differential Scanning Calorimeter (DSC) was used to verify the formation of inclusion complexes. Results: The results showed that the inclusion between rutin and HP-β-CD had been successfully formed. The surface morphologies of nanofibrous membranes were characterized by Scanning Electron Microscope (SEM), which indicated that adding RT/HP-β-CD inclusion complexes had little influence on the morphologies and diameters of the fibers. Ultraviolet resistant results also confirmed the inclusion complex had increased the loading amount in the final nanofibrous mats, and thus had good ultraviolet resistant properties. Conclusion: The formed inclusion complexes had obviously enhanced the loading amount of rutin in electrospun PVA nanofibers, indicating that encapsulation of rutin in the cavity of HP-β-CD is a good way to increase the loading amount.

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