Preparation of polyvinyl alcohol, chitosan and polyurethane-based pH-sensitive and biodegradable hydrogels for controlled drug release applications

2019 ◽  
Vol 69 (18) ◽  
pp. 1167-1177 ◽  
Author(s):  
Umran Duru Kamacı ◽  
Musa Kamacı
Keyword(s):  
Drug Release ◽  
Polyvinyl Alcohol ◽  
Controlled Drug Release ◽  
Ph Sensitive ◽  
Biodegradable Hydrogels

scholarly journals ATRP-based synthesis of a pH-sensitive amphiphilic block polymer and its self-assembled micelles with hollow mesoporous silica as DOX carriers for controlled drug release

RSC Advances ◽  
2021 ◽  
Vol 11 (48) ◽  
pp. 29986-29996
Author(s):  
Xiuxiu Qi ◽  
Hongmei Yan ◽  
Yingxue Li
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Self Assembly ◽  
Drug Loading ◽  
Controlled Drug Release ◽  
Ph Sensitive ◽  
Core Shell ◽  
Assembly Process ◽  
Block Polymer ◽  
Hollow Mesoporous Silica

A pH-sensitive core–shell nanoparticle (HMS@C18@PSDMA-b-POEGMA) was developed via a self-assembly process as the carrier of anticancer drug doxorubicin (DOX) for drug loading and controlled release.

Biodegradable Hydrogels for Controlled Drug Release

2010 ◽  
pp. 147-155 ◽  
Author(s):  
Luis García ◽  
María Rosa Aguilar ◽  
Julio San Román
Keyword(s):  
Drug Release ◽  
Controlled Drug Release ◽  
Biodegradable Hydrogels

The Synthesis and Characterization of PVA-Ketoprofen Cryogel, Biomaterial with Extended Drug Release Properties for Cartilage Replacement

2014 ◽  
Vol 216 ◽  
pp. 205-209
Author(s):  
Monica Cretan Stamate ◽  
Ciprian Stamate
Keyword(s):  
Articular Cartilage ◽  
Drug Release ◽  
Polyvinyl Alcohol ◽  
Water Solubility ◽  
Physicochemical Characterization ◽  
Gravimetric Method ◽  
Controlled Drug Release ◽  
High Wear Resistance ◽  
Mechanical Resistance ◽  
Swelling Properties

The present paper aims to study the possibility to modify the properties of polyvinyl alcohol (pva) cryogels prepared in the presence of ketoprofen in order to replace the damaged articular cartilage. Articular cartilage is the most important part of articulation characterized by very low friction, high wear resistance, and poor regenerative qualities. Polyvinyl alcohol is a non-expensive polymer, versatile and adaptable to various needs, with exceptional properties such as water solubility, biocompatibility, non-toxicity and with capability to form hydrogels by chemical or physical methods. The aims of this paper are the synthesis, the physicochemical characterization and analysis of the tribological properties of pva cryogels for cartilage replacement and the introduction of new concept in medication by creating the cryogel like a controlled drug release system. The morphology of the cryogels, the interaction between the pva macromolecular chains and medicament has been studied by Scanning Electronic Microscopy. The gels swelling in physiologic ser have been monitored by gravimetric method in order to evidence the hydrophilic properties. The mechanical properties of the cryogels have been investigated by dynamic mechanical measurements. In conclusion, the biomaterial obtained provides good swelling properties, mechanical resistance and it is ideal for extended drug release implantable systems.

Manipulation of pH-Sensitive interactions between podophyllotoxin-chitosan for enhanced controlled drug release

2017 ◽  
Vol 95 ◽  
pp. 451-461 ◽  
Author(s):  
Chao Chen ◽  
Yong Yu ◽  
Xiaoli Wang ◽  
Ping Shi ◽  
Yibing Wang ◽  
...  
Keyword(s):  
Drug Release ◽  
Controlled Drug Release ◽  
Ph Sensitive

Preparation and characterization of antibacterial magnetic-/pH-sensitive alginate/Ag/Fe3O4 hydrogel beads for controlled drug release

2020 ◽  
Vol 154 ◽  
pp. 134-141 ◽  
Author(s):  
Bahaaldin Rashidzadeh ◽  
Ebrahim Shokri ◽  
Gholam Reza Mahdavinia ◽  
Reza Moradi ◽  
Sarvin Mohamadi-Aghdam ◽  
...  
Keyword(s):  
Drug Release ◽  
Controlled Drug Release ◽  
Ph Sensitive ◽  
Hydrogel Beads
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