Role of the Structural Elements of the Arterial Wall in the Formation and Growth of Intracranial Saccular Aneurysms

F. T. Mérei; F. Gallyas

doi:10.1080/01616412.1980.11739584

“Eternal Bodies”: images of archangels in the upper parts of Nubian buildings

10.31338/uw.2083-537x.pam29.2.30 ◽

2020 ◽

pp. 713-736

Author(s):

Magdalena Łaptaś

Keyword(s):

Near East ◽

Structural Elements ◽

Christian Art ◽

The Earth ◽

Cosmic Space

Images of archangels and angels, which were painted on the walls, in the upper parts of the buildings and, on their structural elements, were very popular in Christian Nubian painting as attested by the discoveries from Church SWN.BV on the citadel in Old Dongola. These images, which derive from pre-Christian art, depict the eternal nature of the archangels and angels. Presenting this group of representations, the author traces the origins of these images to highlight the role of these spiritual beings as intermediaries between God and humankind. As such, they move freely between the Heavens and the Earth, so the air and cosmic space are their natural surroundings. Moreover, archangels govern the forces of nature, the planets, and the seven skies. Therefore, their sanctuaries were located on hill summits, in the upper chapels, on structural elements of ecclesiastical buildings, etc. The Nubian tradition is therefore part of a broader Mediterranean tradition, the roots of which should be sought in the Near East.

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Planning of infrastructures and the role of remote analysis of structural elements in the bedrock

Geologiska Foereningan i Stockholm Foerhandlingar ◽

10.1080/11035899309452766 ◽

1993 ◽

Vol 115 (3) ◽

pp. 275-277

Author(s):

Sven A. Tirén

Keyword(s):

Structural Elements ◽

Remote Analysis

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Structural elements in the flexible tail of the co-chaperone p23 coordinate client binding and progression of the Hsp90 chaperone cycle

Nature Communications ◽

10.1038/s41467-021-21063-0 ◽

2021 ◽

Vol 12 (1) ◽

Author(s):

Maximilian M. Biebl ◽

Abraham Lopez ◽

Alexandra Rehn ◽

Lee Freiburger ◽

Jannis Lawatscheck ◽

...

Keyword(s):

Proximal Region ◽

Tryptophan Residue ◽

Structural Elements ◽

Physiological Importance ◽

In Vivo Experiments ◽

Cellular Context ◽

Catalytic Loop ◽

Hsp90 Chaperone

AbstractThe co-chaperone p23 is a central part of the Hsp90 machinery. It stabilizes the closed conformation of Hsp90, inhibits its ATPase and is important for client maturation. Yet, how this is achieved has remained enigmatic. Here, we show that a tryptophan residue in the proximal region of the tail decelerates the ATPase by allosterically switching the conformation of the catalytic loop in Hsp90. We further show by NMR spectroscopy that the tail interacts with the Hsp90 client binding site via a conserved helix. This helical motif in the p23 tail also binds to the client protein glucocorticoid receptor (GR) in the free and Hsp90-bound form. In vivo experiments confirm the physiological importance of ATPase modulation and the role of the evolutionary conserved helical motif for GR activation in the cellular context.

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Demand and Defective Growth Patterns: The Role of The Tradable and Non-Tradable Sectors in an Open Economy

The American Economic Review ◽

10.1257/aer.104.5.272 ◽

2014 ◽

Vol 104 (5) ◽

pp. 272-277 ◽

Cited By ~ 3

Author(s):

Sandile Hlatshwayo ◽

Michael Spence

Keyword(s):

Open Economy ◽

Aggregate Demand ◽

Value Added ◽

Growth Patterns ◽

Structural Elements ◽

Total Income ◽

Us Economy ◽

The Us ◽

Tradable Sector

This paper examines the underlying structural elements of US growth patterns, pre- and post-crisis. Prior to the recession, the US economy exhibited a defective growth pattern driven by outsized domestic demand. As domestic aggregate demand retreats to more sustainable levels relative to total income, the tradable side of the economy is a catalyst for restoring strong growth. A structural rebalancing is already underway; although it is only a third of the economy, the tradable sector generated more than half of gross gains in value-added since the start of the recovery. However, distributional issues loom on the horizon.

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The Role of the Conclusions of the Council of Judges of the Russian Federation in the Prevention of the Emergence and Development of Conflicts of Legal Interests in the Judicial System of Russia

RUSSIAN JUSTICE ◽

10.37399/issn2072-909x.2020.12.56-66 ◽

2020 ◽

Vol 12 ◽

pp. 56-66

Author(s):

E. V. Ryabtseva ◽

Keyword(s):

Russian Federation ◽

Judicial System ◽

Structural Elements ◽

Consistent System ◽

Optimal Behavior ◽

Regulatory Impact ◽

The Russian Federation ◽

The Impact ◽

Individual Regulation

The growing role of the judicial community in reforming the judicial system actualizes the scientific problems of law enforcement associated with understanding the essence of the regulatory impact of the Councils of Judges of the Russian Federation as a body of the judicial community to prevent the emergence of conflicts of legal interests in judicial activity. The purpose of the research is to theoretically substantiate the essence of individual regulation of conflicts of legal interests by the Council of Judges of the Russian Federation, aimed at optimizing its activities to combat corruption. The worldview and methodological basis were the works of theoretical scholars and their methods of integrative understanding of law to substantiate the impact of the Council of Judges of the Russian Federation on judicial activity through individual regulation. The conclusion is substantiated that the activities of the Commission of the Council of Judges of the Russian Federation on Ethics, related to the drawing up of opinions on the assessment of conflicts of legal interests and other corruption risks for both acting judges and retired judges, is an individual regulation of legal relations through: interpretation of law; overcoming gaps and conflicts in the law; individuali zation of rights, etc. The content of the interpretation of law by the Commission of the Council of Judges of the Russian Federation on Ethics is: the application of certain norms of both international and national law in a specific legal relationship when assessing conflicts of legal interests among judges through a systematic interpretation of the norms of law as a system of elements, defining its role in law, identifying other norms, as well as the principles of law; interpretation of the principles and norms of law, through the legal-logical interpretation of a normative act as logically interconnected structural elements of a single, internally agreed and consistent system of principles and norms of law, when deciding on the presence of conflicts of legal interests in the activities of judges, etc. The paper substantiates that in relation to conflicts of legal interests, individualization should be aimed at determining by the Council of Judges of the Russian Federation typical situations of such conflicts for their correct assessment and development of recommendations related to the optimal behavior of judges, when circumstances arise that lead to conflicts of legal interests.

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Abstract 12770: The Significant Role of Endothelium and Arterial Wall Properties in Patients With Pseudoexfoliative Glaucoma

Circulation ◽

10.1161/circ.132.suppl_3.12770 ◽

2015 ◽

Vol 132 (suppl_3) ◽

Author(s):

Georgia Siasou ◽

Gerasimos Siasos ◽

Marilita M Moschos ◽

Nikolaos Gouliopoulos ◽

Evangelos Oikonomou ◽

...

Keyword(s):

Arterial Stiffness ◽

Endothelial Function ◽

Significant Role ◽

Vascular Function ◽

Arterial Wall ◽

Augmentation Index ◽

Open Angle Glaucoma ◽

Anterior Segment ◽

Pseudoexfoliative Glaucoma

Introduction: Primary open-angle glaucoma (POAG) is one of the most prevalent causes of irreversible blindness and is associated with endothelial dysfunction and arterial stiffness. Pseudoexfoliative glaucoma (PEG) is another type of glaucoma observed in pseudoexfoliation syndrome. It is characterized by the deposition of pseudoexfoliative material not only to the anterior segment of the eye, but also to the vessels, heart and other organs. Hypothesis: Endothelial function and arterial stiffness are impaired in patients with POAG and PEG supporting the significant role of vascular function impairment in the progression of the disease. Methods: Forty four POAG patients, 22 PEG and 38 healthy subjects (Cl) were included in this study. All subjects were free of cardiovascular or inflammatory diseases. Endothelial function was evaluated by flow-mediated dilatation (FMD). Carotid-femoral pulse wave velocity (PWV) was measured as an index of aortic stiffness and augmentation index (AIx) as a measure of arterial wave reflections Results: Between the three study groups CL, POAG, PEG there was no difference in age (67±10years vs. 70±9years vs. 66±12yeras, p=0.12) or prevalence of male sex (70% vs. 57% vs. 50%, p=0.21). Importantly, there was a linear impairment of FMD (7.35±2.77% vs. 6.58±3.18% vs. 4.88±3.29%, p=0.006), PWV (7.98±1.56m/sec vs. 9.20±1.84m/sec vs. 9.22±2.16m/sec, p=0.004) and AIx (21.29±8.77% vs. 25.14±5.71% vs. 28.20±8.75%, p=0.002) from CL to POAG and PEG. Interestingly post hoc test after Scheffe correction revealed also that PEG subjects had not only significantly impaired FMD, compared to control subjects, but also compared to POAG subjects (4.88±3.29% vs. 6.58±3.18%, p=0.02). Conclusions: Endothelial function and arterial stiffness are significantly impaired in patients with pseudoexfoliative glaucoma. These findings shed some light in the pathophysiology of pseudoexfoliative glaucoma and support the theory that pseudoexfoliative fibrils may also accumulate and damage the arterial wall.

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