Vitamin D Supplementation and Survival in Metastatic Colorectal Cancer

2018 ◽  
Vol 70 (3) ◽  
pp. 413-417 ◽  
Author(s):  
Z. Antunac Golubić ◽  
I. Baršić ◽  
N. Librenjak ◽  
S. Pleština
Keyword(s):  
Colorectal Cancer ◽  
Vitamin D ◽  
Metastatic Colorectal Cancer ◽  
Vitamin D Supplementation

scholarly journals Calcium plus Vitamin D Supplementation and the Risk of Colorectal Cancer

2006 ◽  
Vol 354 (7) ◽  
pp. 684-696 ◽  
Author(s):  
Jean Wactawski-Wende ◽  
Jane Morley Kotchen ◽  
Garnet L. Anderson ◽  
Annlouise R. Assaf ◽  
Robert L. Brunner ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Vitamin D ◽  
Vitamin D Supplementation

scholarly journals Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Body Composition among Patients with Advanced or Metastatic Colorectal Cancer: A Randomized Trial

Cancers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3451
Author(s):  
Justin C. Brown ◽  
Michael H. Rosenthal ◽  
Chao Ma ◽  
Sui Zhang ◽  
Halla S. Nimeiri ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Vitamin D ◽  
Body Composition ◽  
Adipose Tissue ◽  
Metastatic Colorectal Cancer ◽  
Vitamin D3 ◽  
Standard Dose ◽  
High Dose ◽  
Tissue Area ◽  
High Dose Vitamin

Skeletal muscle and adipose tissue express the vitamin D receptor and may be a mechanism through which vitamin D supplementation slows cancer progression and reduces cancer death. In this exploratory analysis of a double-blind, multicenter, randomized phase II clinical trial, 105 patients with advanced or metastatic colorectal cancer who were receiving chemotherapy were randomized to either high-dose vitamin D3 (4000 IU) or standard-dose (400 IU) vitamin D3. Body composition was measured with abdominal computed tomography at enrollment (baseline) and after cycle 8 of chemotherapy (16 weeks). As compared with standard-dose vitamin D3, high-dose vitamin D3 did not significantly change body weight [−0.7 kg; (95% CI: −3.5, 2.0)], body mass index [−0.2 kg/m2; (95% CI: −1.2, 0.7)], muscle area [−1.7 cm2; (95% CI: −9.6, 6.3)], muscle attenuation [−0.4 HU; (95% CI: −4.2, 3.2)], visceral adipose tissue area [−7.5 cm2; (95% CI: −24.5, 9.6)], or subcutaneous adipose tissue area [−8.3 cm2; (95% CI: −35.5, 18.9)] over the first 8 cycles of chemotherapy. Among patients with advanced or metastatic colorectal cancer, the addition of high-dose vitamin D3, vs standard-dose vitamin D3, to standard chemotherapy did not result in any changes in body composition.

scholarly journals Calcium Plus Vitamin D Supplementation and the Risk of Colorectal Cancer

2006 ◽  
Vol 61 (6) ◽  
pp. 389-390
Author(s):  
Jean Wactawski-Wende ◽  
Jane Morley Kotchen ◽  
Garnet L. Anderson ◽  
Annlouise R. Assaf ◽  
Robert L. Brunner ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Vitamin D ◽  
Vitamin D Supplementation

Vitamin D status and survival of metastatic colorectal cancer patients: Results from CALGB/SWOG 80405 (Alliance).

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. 3503-3503 ◽  
Author(s):  
Kimmie Ng ◽  
Alan P. Venook ◽  
Kaori Sato ◽  
Chen Yuan ◽  
Bruce W. Hollis ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Vitamin D ◽  
Metastatic Colorectal Cancer ◽  
Cancer Patients ◽  
Vitamin D Status ◽  
Colorectal Cancer Patients

scholarly journals The effect of vitamin D supplementation on survival in patients with colorectal cancer: systematic review and meta-analysis of randomised controlled trials

2020 ◽  
Vol 123 (11) ◽  
pp. 1705-1712 ◽  
Author(s):  
Peter G. Vaughan-Shaw ◽  
Louis F. Buijs ◽  
James P. Blackmur ◽  
Evi Theodoratou ◽  
Lina Zgaga ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Vitamin D ◽  
High Risk ◽  
Meta Analysis ◽  
Vitamin D Supplementation ◽  
Risk Of Bias ◽  
Survival Outcomes ◽  
Vitamin D Levels ◽  
Randomised Controlled ◽  
Incident Cases

Abstract Background Low circulating vitamin D levels are associated with poor colorectal cancer (CRC) survival. We assess whether vitamin D supplementation improves CRC survival outcomes. Methods PubMed and Web of Science were searched. Randomised controlled trial (RCTs) of vitamin D supplementation reporting CRC mortality were included. RCTs with high risk of bias were excluded from analysis. Random-effects meta-analysis models calculated estimates of survival benefit with supplementation. The review is registered on PROSPERO, registration number: CRD42020173397. Results Seven RCTs (n = 957 CRC cases) were identified: three trials included patients with CRC at outset, and four population trials reported survival in incident cases. Two RCTs were excluded from meta-analysis (high risk of bias; no hazard ratio (HR)). While trials varied in inclusion criteria, intervention dose and outcomes, meta-analysis found a 30% reduction in adverse CRC outcomes with supplementation (n = 815, HR = 0.70; 95% confidence interval (CI): 0.48–0.93). A beneficial effect was seen in trials of CRC patients (progression-free survival, HR = 0.65; 95% CI: 0.36–0.94), with suggestive effect in incident CRC cases from population trials (CRC-specific survival, HR = 0.76; 95% CI: 0.39–1.13). No heterogeneity or publication bias was noted. Conclusions Meta-analysis demonstrates a clinically meaningful benefit of vitamin D supplementation on CRC survival outcomes. Further well-designed, adequately powered RCTs are needed to fully evaluate benefit of supplementation in augmenting ‘real-life’ follow-up and adjuvant chemotherapy regimens, as well as determining optimal dosing.

scholarly journals Low plasma vitamin D is associated with adverse colorectal cancer survival after surgical resection, independent of systemic inflammatory response

Gut ◽  
2019 ◽  
Vol 69 (1) ◽  
pp. 103-111 ◽  
Author(s):  
P G Vaughan-Shaw ◽  
L Zgaga ◽  
L Y Ooi ◽  
E Theodoratou ◽  
M Timofeeva ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Vitamin D ◽  
Inflammatory Response ◽  
Surgical Resection ◽  
Cancer Survival ◽  
Randomised Trial ◽  
Area Under The Curve ◽  
Vitamin D Supplementation ◽  
Systemic Inflammatory Response ◽  
Plasma Vitamin

ObjectiveWe assessed the effect of surgical resection of colorectal cancer (CRC) on perioperative plasma vitamin D (25OHD) and C-reactive protein (CRP) level. We investigated the relationship between circulating vitamin D level and CRC survival.DesignWe sequentially sampled 92 patients undergoing CRC resection, and measured plasma 25OHD and CRP. For survival analyses, we assayed 25OHD and CRP in two temporally distinct CRC patient cohorts (n=2006, n=2100) and investigated the association between survival outcome, circulating vitamin D and systemic inflammatory response.ResultsSerial sampling revealed a postoperative fall (mean 17.3 nmol/L; p=3.6e-9) in plasma 25OHD (nadir days 1–2). CRP peaked 3–5 days postoperatively (143.1 mg/L; p=1.4e-12), yet the postoperative fall in 25OHD was independent of CRP. In cohort analyses, 25OHD was lower in the 12 months following operation (mean=48.8 nmol/L) than preoperatively (54.8 nmol/L; p=1.2e-5) recovering after 24 months (52.2 nmol/L; p=0.002). Survival analysis in American Joint Committee on Cancer stages I–III demonstrated associations between 25OHD tertile and CRC mortality (HR=0.69; 95% CI 0.46 to 0.91) and all-cause mortality (HR=0.68; 95% CI 0.50 to 0.85), and was independent of CRP. We observed interaction effects between plasma 25OHD and rs11568820 genotype (functional VDR polymorphism) with a strong protective effect of higher 25OHD only in patients with GG genotype (HR=0.51; 95% CI 0.21 to 0.81). We developed an online tool for predicted survival (https://apps.igmm.ed.ac.uk/mortalityCalculator/) that incorporates 25OHD with clinically useful predictive performance (area under the curve 0.77).ConclusionsCRC surgery induces a fall in circulating 25OHD. Plasma 25OHD level is a prognostic biomarker with low 25OHD associated with poorer survival, particularly in those with rs11568820 GG genotype. A randomised trial of vitamin D supplementation after CRC surgery has compelling rationale.

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