Hospital design and the temporal and spatial organization of nursing activity

Work & Stress ◽  
1992 ◽  
Vol 6 (3) ◽  
pp. 277-291 ◽  
Author(s):  
C. Gadbois ◽  
P. Bourgeois ◽  
M. M. Goeh-Akue-Gad ◽  
J. Guillaume ◽  
M. A. Urbain
2003 ◽  
Vol 185 (15) ◽  
pp. 4585-4592 ◽  
Author(s):  
Jeremy S. Webb ◽  
Lyndal S. Thompson ◽  
Sally James ◽  
Tim Charlton ◽  
Tim Tolker-Nielsen ◽  
...  

ABSTRACT Bacteria growing in biofilms often develop multicellular, three-dimensional structures known as microcolonies. Complex differentiation within biofilms of Pseudomonas aeruginosa occurs, leading to the creation of voids inside microcolonies and to the dispersal of cells from within these voids. However, key developmental processes regulating these events are poorly understood. A normal component of multicellular development is cell death. Here we report that a repeatable pattern of cell death and lysis occurs in biofilms of P. aeruginosa during the normal course of development. Cell death occurred with temporal and spatial organization within biofilms, inside microcolonies, when the biofilms were allowed to develop in continuous-culture flow cells. A subpopulation of viable cells was always observed in these regions. During the onset of biofilm killing and during biofilm development thereafter, a bacteriophage capable of superinfecting and lysing the P. aeruginosa parent strain was detected in the fluid effluent from the biofilm. The bacteriophage implicated in biofilm killing was closely related to the filamentous phage Pf1 and existed as a prophage within the genome of P. aeruginosa. We propose that prophage-mediated cell death is an important mechanism of differentiation inside microcolonies that facilitates dispersal of a subpopulation of surviving cells.


2015 ◽  
Vol 599 ◽  
pp. 75-80 ◽  
Author(s):  
Kristel Knaepen ◽  
Andreas Mierau ◽  
Helio Fernandez Tellez ◽  
Dirk Lefeber ◽  
Romain Meeusen

2018 ◽  
Vol 50 ◽  
pp. 01036
Author(s):  
Larissa Vikulova ◽  
Evgeniia Serebrennikova ◽  
Olga Vostrikova ◽  
Liudmila Borbotko

The paper attempts to define constituting features of theatrical discourse which determine functioning of the latter in theatre communicative space. Communication code moderates the addresser-addressee interrelations thus playing a key role in the realization of theatrical discourse as a ritualized, institutional and conventional semiotic unit. The study also aims at introducing a typology of theatrical discourse participants and at defining the addressing vector direction. Communication code is estimated as a moderator of theatrical communication processes and an indicator of communication success / failure. The audience is viewed as a social addressee – an element obligatory for theatrical discourse to be externalized. The audience’s behavioral pattern is largely attributed to the existing communication code: the audience is conscious of their silent role, the verbal communication being somewhat one-way. Conversely, theatrical discourse implies reaction on behalf of the audience. The communication code significantly affects the temporal and spatial framework of theatre communication alongside the actual theatre space existence. The social cultural institution of theatre is targeted at sustaining the society moral values and forming new cognitive and ethical ones. These functions of theatre are also of primary importance. The research results in the drafted principles of the code of verbal communication applied to theatrical discourse, viz. the principle of temporal and spatial organization; the principle of muteness; the principle of prescript observation and the axiological awareness principle.


2020 ◽  
pp. jcs.244376
Author(s):  
Shiran Gabay-Maskit ◽  
Luis Daniel Cruz-Zaragoza ◽  
Nadav Shai ◽  
Miriam Eisenstein ◽  
Chen Bibi ◽  
...  

Eukaryotic cells evolved organelles that allow the compartmentalization and regulation of metabolic processes. Knowledge on molecular mechanisms that allow temporal and spatial organization of enzymes within organelles is therefore critical for understanding eukaryotic metabolism. Here we show that the yeast malate dehydrogenase 2 (Mdh2) is dually localized to the cytosol and to peroxisomes and is targeted to peroxisomes via association with Mdh3 and a Pex5-dependent piggybacking mechanism. The dual localization of Mdh2 contributes to our understanding of the glyoxylate cycle and provides a new perspective on compartmentalization of cellular metabolism, which is critical for the perception of metabolic disorders and aging.


2008 ◽  
Vol 112 (20) ◽  
pp. 4584-4592 ◽  
Author(s):  
Vladimir V. Udovichenko ◽  
Peter E. Strizhak ◽  
Agata Toth ◽  
Dezso Horwath ◽  
Steven Ning ◽  
...  

Author(s):  
Inna Gazheva

The article attempts to identify systemic intertextual connections between novellas “The Barrier” by Pavel Vezhinov and “A Gentle Creature” by Fyodor Dostoyevsky (as well as individual intertextual connections between “The Barrier” and “The Dream of a Ridiculous Man”) and show how their explication contributes to the comprehension of the artistic concept of each of the works. The methodological basis of the study is the interpretation of intertextuality as a product of reading (not as a phenomenon of “writing”), according to which Vezhinov and Dostoevsky – writers belonging to different national cultures and historical eras – in some sense become contemporaries. Accordingly, “A Gentle Creature”, written earlier, is enriched in meaning as a result of its comparison with “The Barrier”, as well as the latter by comparison with the story of Dostoevsky. The basis for comparing the stories is the similarity at the level of the storylines, the narrative type, the system of the characters. At the same time, the ways of transforming the storyline into a plot, such as: external composition, focalisation, organization of modal-temporal and spatial plans, are deeply different. The spatial organization of the works plays a particularly important role in this sense, since the storyline of both stories is based on one type of rite de passage – the transition from life “to another life”. This article is devoted to the question of whether this transition took place and whether, as a result, the spiritual transformation of the main characters took place.


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