The Role of Functional Analysis in National Vocational Qualifications: A Critical Appraisal

1995 ◽  
Vol 8 (2) ◽  
pp. 93-106 ◽  
Author(s):  
Jim Stewart ◽  
Sally Sambrook
Keyword(s):  
Functional Analysis ◽  
Critical Appraisal ◽  
Vocational Qualifications

935: Critical Appraisal of the Role of Ureteroscopy in Treatment of Pediatric Renal and Ureteric Calculi

2007 ◽  
Vol 177 (4S) ◽  
pp. 310-310
Author(s):  
Sumit Dave ◽  
Luis H. Braga ◽  
Antoine E. Khoury ◽  
Walid A. Farhat
Keyword(s):  
Critical Appraisal ◽  
Ureteric Calculi

scholarly journals Understanding the nature and scope of clinical research commentaries in PubMed

2019 ◽  
Vol 27 (3) ◽  
pp. 449-456
Author(s):  
James R Rogers ◽  
Hollis Mills ◽  
Lisa V Grossman ◽  
Andrew Goldstein ◽  
Chunhua Weng
Keyword(s):  
Clinical Research ◽  
Sentiment Analysis ◽  
Random Sample ◽  
Full Text ◽  
Topic Modeling ◽  
Critical Appraisal ◽  
Research Articles ◽  
Disease Specific ◽  
Research Studies

Abstract Scientific commentaries are expected to play an important role in evidence appraisal, but it is unknown whether this expectation has been fulfilled. This study aims to better understand the role of scientific commentary in evidence appraisal. We queried PubMed for all clinical research articles with accompanying comments and extracted corresponding metadata. Five percent of clinical research studies (N = 130 629) received postpublication comments (N = 171 556), resulting in 178 882 comment–article pairings, with 90% published in the same journal. We obtained 5197 full-text comments for topic modeling and exploratory sentiment analysis. Topics were generally disease specific with only a few topics relevant to the appraisal of studies, which were highly prevalent in letters. Of a random sample of 518 full-text comments, 67% had a supportive tone. Based on our results, published commentary, with the exception of letters, most often highlight or endorse previous publications rather than serve as a prominent mechanism for critical appraisal.

A critical appraisal of the role of respiratory supercomplexes in mitochondria

2013 ◽  
Vol 394 (5) ◽  
pp. 631-639 ◽  
Author(s):  
Maria Luisa Genova ◽  
Giorgio Lenaz
Keyword(s):  
Critical Appraisal ◽  
Dynamic Equilibrium ◽  
Coenzyme Q ◽  
Mitochondrial Respiratory Chain ◽  
Substantial Evidence ◽  
Mammalian Mitochondria ◽  
Respiratory Supercomplexes ◽  
Functional Relevance ◽  
The Individual

Abstract Substantial evidence exists that the mitochondrial respiratory chain is organized in supramolecular units called supercomplexes or respirasomes. While the structural evidence of the supercomplexes is overwhelming, fewer studies have focused on their functional relevance. Although the presence of coenzyme Q channeling between complexes I and III has been ascertained, no such clear demonstration has been carried out for cytochrome c between complexes III and IV, at least in mammalian mitochondria. This review also discusses the implications concerning the number of respiratory complexes organized in supercomplexes and the possibility that they represent associations in dynamic equilibrium with the individual complexes.

Role of cytology and immunochemistry in diagnosis of metastatic malignancies in the lung: A critical appraisal

2018 ◽  
Vol 46 (11) ◽  
pp. 936-944
Author(s):  
Varsha Manucha ◽  
Jeffery T. Hansen ◽  
Maria F. Gonzalez ◽  
Israh Akhtar
Keyword(s):  
Critical Appraisal

scholarly journals Fine Mapping and Functional Analysis Reveal a Role of SLC22A1 in Acylcarnitine Transport

2017 ◽  
Vol 101 (4) ◽  
pp. 489-502 ◽  
Author(s):  
Hye In Kim ◽  
Johannes Raffler ◽  
Wenyun Lu ◽  
Jung-Jin Lee ◽  
Deepti Abbey ◽  
...  
Keyword(s):  
Functional Analysis ◽  
Fine Mapping

Functional analysis of the SUMOylation pathway in Drosophila

2008 ◽  
Vol 36 (5) ◽  
pp. 868-873 ◽  
Author(s):  
Ana Talamillo ◽  
Jonatan Sánchez ◽  
Rosa Barrio
Keyword(s):  
Functional Analysis ◽  
Fine Tuning ◽  
Model Systems ◽  
Post Translational Modification ◽  
Reversible Process ◽  
Cellular Processes ◽  
Tuning Mechanism ◽  
Sumo Conjugation

SUMOylation, a reversible process used as a ‘fine-tuning’ mechanism to regulate the role of multiple proteins, is conserved throughout evolution. This post-translational modification affects several cellular processes by the modulation of subcellular localization, activity or stability of a variety of substrates. A growing number of proteins have been identified as targets for SUMOylation, although, for many of them, the role of SUMO conjugation on their function is unknown. The use of model systems might facilitate the study of SUMOylation implications in vivo. In the present paper, we have compiled what is known about SUMOylation in Drosophila melanogaster, where the use of genetics provides new insights on SUMOylation's biological roles.

scholarly journals Genetic Analysis of Neuroligin 4Y Gene in Autism Population of India

2021 ◽  
Author(s):  
Rajat Hegde ◽  
Smita Hegde ◽  
Suyamindra S. Kulkarni ◽  
Aditya Pandurangi ◽  
Pramod B. Gai ◽  
...  
Keyword(s):  
Functional Analysis ◽  
Genetic Analysis ◽  
Missense Mutation ◽  
Mentally Ill ◽  
Large Population ◽  
Original Structure ◽  
Male Predominance ◽  
Local Configuration ◽  
Autistic Population

Abstract Background Autism is one of the most complex, heterogeneous neurological disorders. It is characterized mainly by abnormal communication, impaired social interaction, and restricted behaviors. Prevalence of autism is not clear in Indian population. Aim The present study hypothesizes that Y chromosome plays role in sex bias of autism in Indian autistic population. To investigate our hypothesis, we underwent genetic analysis of neuroligin 4Y [NLGN4Y] gene by sequencing 85 male autistic children after screening large population of 1,870 mentally ill children from North Karnataka region of India. Result Detailed sequencing of the single targeted gene revealed nine variants including, one novel missense mutation and eight synonymous variants; this accounts for 88.9% of synonymous variants. A single novel missense mutation is predicted to be nonpathogenic on the functions of neuroligin4Y protein but it slightly affects the local configuration by altering the original structure of a protein by changing charge and size of amino acid. Conclusion Probably NLGN4Y gene may not be the risk factor for autism in male children in Indian autistic population. Functional analysis was an important limitation of our study. Therefore, detailed functional analysis is necessary to determine the exact role of novel missense mutation of neuroligin 4Y [NLGN4Y] gene especially in the male predominance of autism in Indian autistic population.

Structural and functional analysis of reconnaissance and fire system and decomposition of its functions and subsystems

2021 ◽  
pp. 38-48
Author(s):  
O. Maistrenko ◽  
O. Karavanov ◽  
A. Shcherba
Keyword(s):  
Functional Analysis ◽  
Fire Damage ◽  
Expert Group ◽  
Expert Evaluation ◽  
Military Conflicts ◽  
Main Factors ◽  
The Stability ◽  
The Impact

It is established that the role of reconnaissance and fire systems in the implementation of enemy fire damage in military conflicts occurring at the beginning of the XXI century. Increased  to 75%. However, it was found that the effectiveness of these systems depends on the quality of their equipment. The main factors that are often not taken into account in the acquisition are the possibility, interoperability, stability of each element, the impact of elements on the stability of each other and the functioning of the RVS as a whole. The analysis of recent research and publications has shown that as of today, the approaches to determining the composition of reconnaissance fire systems taking into account these factors are not justified. Given the above, it was decided to conduct a structural and functional analysis of the reconnaissance fire system and the decomposition of its functions and subsystems. To this end, based on the method of cluster analysis, an algorithm for combining a set of tasks performed by reconnaissance and fire systems into groups has been developed and substantiated. The method of expert evaluation was used to obtain substantiated data on the implementation of such a merger. According to the proposed algorithm, the main tasks were first identified, which involve reconnaissance and fire systems. Subsequently, an expert group was formed and the coefficient of relative competence of each member of the expert group was determined. The experts were then asked to combine the identified tasks according to their characteristics into an arbitrary number of groups. After processing the opinions of experts, 10 characteristic groups were identified. Finally, the experts were asked to combine the obtained groups in such a way that each association consisted of similar objects and the objects of different associations differed significantly. The results of the work revealed the functional interconnectedness of the tasks, processes and subsystems of the reconnaissance and fire system. It is also established that a typical reconnaissance fire system will consist of three subsystems (control, reconnaissance and fire influence), which perform specific functions for each of them.

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