scholarly journals Impact of age, intrinsic subtype and local treatment on long-term local-regional recurrence and breast cancer mortality among low-risk breast cancer patients

2016 ◽  
Vol 56 (1) ◽  
pp. 59-67 ◽  
Author(s):  
Tinne Laurberg ◽  
Jan Alsner ◽  
Trine Tramm ◽  
Vibeke Jensen ◽  
Christina D. Lyngholm ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Cancer Mortality ◽  
Breast Cancer Mortality ◽  
Local Treatment ◽  
Intrinsic Subtype ◽  
Breast Cancer Patients ◽  
Local Regional Recurrence ◽  
Risk Breast Cancer

scholarly journals Relationship of Predicted Risk of Developing Invasive Breast Cancer, as Assessed with Three Models, and Breast Cancer Mortality among Breast Cancer Patients

PLoS ONE ◽  
2016 ◽  
Vol 11 (8) ◽  
pp. e0160966 ◽  
Author(s):  
Mark E. Sherman ◽  
Laura Ichikawa ◽  
Ruth M. Pfeiffer ◽  
Diana L. Miglioretti ◽  
Karla Kerlikowske ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Invasive Breast Cancer ◽  
Cancer Mortality ◽  
Breast Cancer Mortality ◽  
Breast Cancer Patients ◽  
Relationship Of ◽  
Predicted Risk

scholarly journals Physical Activity Before, During, and After Chemotherapy for High-Risk Breast Cancer: Relationships With Survival

2020 ◽  
Vol 113 (1) ◽  
pp. 54-63 ◽  
Author(s):  
Rikki A Cannioto ◽  
Alan Hutson ◽  
Shruti Dighe ◽  
William McCann ◽  
Susan E McCann ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
High Risk ◽  
Cancer Patients ◽  
Breast Cancer Mortality ◽  
Breast Cancer Patients ◽  
Time Points ◽  
High Risk Breast Cancer ◽  
High Risk Breast ◽  
Risk Breast Cancer

Abstract Background Although physical activity has been consistently associated with reduced breast cancer mortality, evidence is largely based on data collected at one occasion. We examined how pre- and postdiagnosis physical activity was associated with survival outcomes in high-risk breast cancer patients. Methods Included were 1340 patients enrolled in the Diet, Exercise, Lifestyle and Cancer Prognosis (DELCaP) Study, a prospective study of lifestyle and prognosis ancillary to a SWOG clinical trial (S0221). Activity before diagnosis, during treatment, and at 1- and 2-year intervals after enrollment was collected. Patients were categorized according to the Physical Activity Guidelines for Americans as meeting the minimum guidelines (yes/no) and incrementally as inactive, low active, moderately active (meeting the guidelines), or high active. Results In joint-exposure analyses, patients meeting the guidelines before and 1 year after diagnosis experienced statistically significant reductions in hazards of recurrence (hazard ratio [HR] = 0.59, 95% confidence interval [CI] = 0.42 to 0.82) and mortality (HR = 0.51, 95% CI = 0.34–0.77); associations were stronger at 2-year follow-up for recurrence (HR = 0.45, 95% CI = 0.31 to 0.65) and mortality (HR = 0.32, 95% CI = 0.19 to 0.52). In time-dependent analyses, factoring in activity from all time points, we observed striking associations with mortality for low- (HR = 0.41, 95% CI = 0.24 to 0.68), moderate- (HR = 0.42, 95% CI = 0.23 to 0.76), and high-active patients (HR = 0.31, 95% CI = 0.18 to 0.53). Conclusions Meeting the minimum guidelines for physical activity both before diagnosis and after treatment appears to be associated with statistically significantly reduced hazards of recurrence and mortality among breast cancer patients. When considering activity from all time points, including during treatment, lower volumes of regular activity were associated with similar overall survival advantages as meeting and exceeding the guidelines.

scholarly journals Breast cancer mortality in synchronous bilateral breast cancer patients

2019 ◽  
Vol 120 (7) ◽  
pp. 761-767 ◽  
Author(s):  
Mathias Kvist Mejdahl ◽  
Jan Wohlfahrt ◽  
Marianne Holm ◽  
Eva Balslev ◽  
Ann Søegaard Knoop ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Cancer Mortality ◽  
Breast Cancer Mortality ◽  
Bilateral Breast Cancer ◽  
Breast Cancer Patients ◽  
Synchronous Bilateral Breast Cancer

Study of Failure Pattern Among High-Risk Breast Cancer Patients With or Without Postmastectomy Radiotherapy in Addition to Adjuvant Systemic Therapy: Long-Term Results From the Danish Breast Cancer Cooperative Group DBCG 82 b and c Randomized Studies

2006 ◽  
Vol 24 (15) ◽  
pp. 2268-2275 ◽  
Author(s):  
Hanne M. Nielsen ◽  
Marie Overgaard ◽  
Cai Grau ◽  
Anni R. Jensen ◽  
Jens Overgaard
Keyword(s):  
Breast Cancer ◽  
High Risk ◽  
Cancer Patients ◽  
Disease Recurrence ◽  
Breast Cancer Patients ◽  
High Risk Breast Cancer ◽  
High Risk Breast ◽  
Risk Breast Cancer

Purpose Postmastectomy radiotherapy (RT) in high-risk breast cancer patients can reduce locoregional recurrences (LRRs) and improve disease-free and overall survival. The aim of this analysis was to examine the overall disease recurrence pattern among patients randomly assigned to receive treatment with or without RT. Patients and Methods A long-term follow-up was performed among the 3,083 patients from the Danish Breast Cancer Cooperative Group 82 b and c trials, except in those already recorded with distant metastases (DM) or contralateral breast cancer (CBC). The end points were LRR, DM, and CBC, and the follow-up continued until DM, CBC, emigration, or death. Information was selected from medical records, general practitioners, and the National Causes of Death Registry. The median potential follow-up time was 18 years. Results The 18-year probability of any first breast cancer event was 73% and 59% (P < .001) after no RT and RT, respectively (relative risk [RR], 0.68; 95% CI, 0.63 to 0.75). The 18-year probability of LRR (with or without DM) was 49% and 14% (P < .001) after no RT and RT, respectively (RR, 0.23; 95% CI, 0.19 to 0.27). The 18-year probability of DM subsequent to LRR was 35% and 6% (P < .001) after no RT and RT, respectively (RR, 0.15; 95% CI, 0.11 to 0.20), whereas the probability of any DM was 64% and 53% (P < .001) after no RT versus RT, respectively (RR, 0.78; 95% CI, 0.71 to 0.86). Conclusion Postmastectomy RT changes the disease recurrence pattern in high-risk breast cancer patients; fewer patients have LRR as first site of recurrence, and overall fewer patients have DM.

scholarly journals Breast cancer mortality disparities: Providers' perspective

2017 ◽  
Vol 7 (6) ◽  
pp. 46 ◽  
Author(s):  
Shelley White-Means ◽  
Jill Dapremont ◽  
Muriel Rice ◽  
Barbara Davis ◽  
Okoia Stoddard
Keyword(s):  
Breast Cancer ◽  
African American ◽  
African American Women ◽  
Cancer Patients ◽  
Cancer Mortality ◽  
White Women ◽  
Care Delivery ◽  
Breast Cancer Mortality ◽  
Breast Cancer Patients ◽  
American Women

This research is part two of a study to gain understanding of reasons for the large breast cancer mortality disparity between African-American and White women who live in Memphis, Tennessee. Among the country’s 25 largest cities, the breast cancer mortality disparity is highest in Memphis, Tennessee, where African-American women are twice as likely to die from breast cancer as White women. In part one of this study, we sought to gain the perspective of African-American breast cancer survivors. Now we explore the perspective from the providers of care who interface with breast cancer patients, health systems, and health insurers. This is a descriptive research study that used qualitative methodology to inteview seven medical, surgical and radiation oncologists who serve African-American breast cancer patients in Memphis. Data were collected using semi-structured in-depth interviews. Themes included: (1) socioeconomic factors; (2) lack of knowledge about treatment, progression and side effects, and diagnosis; (3) information/communication about the diagnosis; (4) support system: need for another person to process information given; (5) limited access and resources: no insurance and no available services for treatment in African-American neighborhoods; and (6) fear of the unknown: fear of cancer, fear of losing breast, and fear about the disease’s impact on personal relationships. These results suggest that resources that aid geographical access to services need to change in order for disparities to decrease. A new model for health care delivery for African-American women at high risk of or diagnosed with breast cancer needs to be developed to address these findings.

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