scholarly journals Immune response to monovalent and bivalent Newcastle disease and infectious bronchitis inactivated vaccines

1977 ◽  
Vol 6 (2) ◽  
pp. 131-142 ◽  
Author(s):  
R.E. Gough ◽  
W.H. Allan ◽  
D. Nedelciu
Keyword(s):  
Immune Response ◽  
Newcastle Disease ◽  
Infectious Bronchitis ◽  
Inactivated Vaccines

scholarly journals Towards Improved Use of Vaccination in the Control of Infectious Bronchitis and Newcastle Disease in Poultry: Understanding the Immunological Mechanisms

Vaccines ◽  
2021 ◽  
Vol 9 (1) ◽  
pp. 20
Author(s):  
Anthony C. Ike ◽  
Chukwuebuka M. Ononugbo ◽  
Okechukwu J. Obi ◽  
Chisom J. Onu ◽  
Chinasa V. Olovo ◽  
...  
Keyword(s):  
Immune Responses ◽  
Newcastle Disease ◽  
Viral Infections ◽  
Advanced Technology ◽  
Global Food Security ◽  
Infectious Bronchitis ◽  
Immunological Mechanisms ◽  
Inactivated Vaccines ◽  
Successful Control ◽  
Cellular Immune

Infectious bronchitis (IB) and Newcastle disease (ND) are two important diseases of poultry and have remained a threat to the development of the poultry industry in many parts of the world. The immunology of avian has been well studied and numerous vaccines have been developed against the two viruses. Most of these vaccines are either inactivated vaccines or live attenuated vaccines. Inactivated vaccines induce weak cellular immune responses and require priming with live or other types of vaccines. Advanced technology has been used to produce several types of vaccines that can initiate prime immune responses. However, as a result of rapid genetic variations, the control of these two viral infections through vaccination has remained a challenge. Using various strategies such as combination of live attenuated and inactivated vaccines, development of IB/ND vaccines, use of DNA vaccines and transgenic plant vaccines, the problem is being surmounted. It is hoped that with increasing understanding of the immunological mechanisms in birds that are used in fighting these viruses, a more successful control of the diseases will be achieved. This will go a long way in contributing to global food security and the economic development of many developing countries, given the role of poultry in the attainment of these goals.

scholarly journals EFFECT OF VITAMIN E AND COD LIVER OIL SUPPLEMENT WITH BIVALENT OIL BASED VACCINE OF NEWCASTLE DISEASE AND INFECTIOUS BRONCHITIS DISEASE ON IMMUNE RESPONSE OF THE BROILERS.

2016 ◽  
Vol 47 (3) ◽  
Author(s):  
ABDULWAHID & et al.
Keyword(s):  
Immune Response ◽  
Vitamin E ◽  
Newcastle Disease ◽  
Challenge Test ◽  
Elisa Test ◽  
The Other ◽  
Control Group ◽  
Broiler Chicks ◽  
Cod Liver Oil ◽  
Infectious Bronchitis

This study was aimed to enhance the immune response of the broilers by vitamin E and Cod liver oil supplement with locally inactivated bivalent vaccine of Newcastle disease and Infectious bronchitis viruses. One hundred and twenty broiler chicks Ross 308 were divided to four groups at 30 chicks of each group. The 2nd group was vaccinated with 0.5ml/chick of locally inactivated ND-IB vaccine at 5 days old. The 3rd group was vaccinated with 0.5ml locally ND-IB vaccine and 0.1 ml/chick of VE. The 4th group was vaccinated with 0.5ml of locally ND-IB vaccine and 0.1ml/chick of Cod liver oil, while the first group was left without vaccination as a control group. All groups were vaccinated with attenuated ND-IB at 3 days old and attenuated IBD at 14 days old. The results of ELISA test revealed that the 3rd and 4th groups showed significantly increased (P≤0.05) in Ab titers against ND virus at aged 35 days, also, the 4th group showed significantly (P≤0.05) increased in Ab titers against IB virus at day 35 of age as compared with the other groups. The 4th group showed a significant (P≤0.05) increased in bursal index as compared with the other groups. The results of challenge test revealed that vaccinated groups resist the velogenic ND and IB viruses with relatively high productive range particularly the 4th group as compared with other groups. In conclusion, the VE and Cod liver oil supplement with local bivalent oil based vaccine of ND and IBV may enhance the immune response of the broilers particularly the 4th group which vaccinated with 0.5 ml of local bivalent oil based vaccine of ND-IB vaccine and 0.1 ml Cod liver oil.

scholarly journals Oral immunoadjuvant activity ofLactobacillus caseisubsp.caseiin dextran-fed layer chickens

2006 ◽  
Vol 95 (2) ◽  
pp. 430-434 ◽  
Author(s):  
Tomohiko Ogawa ◽  
Yasuyuki Asai ◽  
Hiromi Sakamoto ◽  
Kenji Yasuda
Keyword(s):  
Immune Response ◽  
Humoral Immune Response ◽  
Specific Substrate ◽  
Infectious Bronchitis ◽  
Humoral Immune ◽  
Humoral Immune Responses ◽  
Actual Application ◽  
Colony Forming Units ◽  
Inactivated Vaccines ◽  
Layer Chickens

We recently reported that synbioticLactobacillus caseisubsp.caseitogether with specific substrate dextran elicited an enhancement in humoral immune response against bovine serum albumin (BSA) as a model antigen in BALB/c mice. The present study was designed to evaluate the oral immunoadjuvant effects of the synbiotic in layer chickens. Using a PCR assay,L. caseisubsp.caseiwas detected specifically in the intestinal chyme of chickens (10d of age, Julia strain) fedad libitumon a diet supplemented with 75mg dextran/kg (dextran-supplemented diet, DSD) and administered orally with 107colony-forming units (CFU)L. caseisubsp.caseiin 0·1ml PBS with the aid of an intubation needle at 1, 2 and 3d of age. Furthermore, oral administration of 107CFUL. caseisubsp.caseiat 1–3d of age significantly enhanced the production of anti-BSA antibody in DSD-fed chickens (60d of age) administered orally with 1mg BSA at 32 and 33d of age and subcutaneously with 5μg BSA at 33d of age. In addition, among bacterial numbers tested, 106CFUL. caseisubsp.caseitogether with dextran induced an effective increase in humoral immune response to mixed inactivated vaccines against Newcastle disease and avian infectious bronchitis, and the treatment may be advantageous in protecting against these infectious diseases in chickens in actual application. These results suggest that dietary supplementation ofL. caseisubsp.caseiwith dextran leads to immunomodulation of humoral immune responses.

scholarly journals Adjuvant Activity of Sargassum pallidum Polysaccharides against Combined Newcastle Disease, Infectious Bronchitis and Avian Influenza Inactivated Vaccines

Marine Drugs ◽  
2012 ◽  
Vol 10 (12) ◽  
pp. 2648-2660 ◽  
Author(s):  
Li-Jie Li ◽  
Ming-Yi Li ◽  
Yan-Tuan Li ◽  
Jing-Jing Feng ◽  
Feng-Qiang Hao ◽  
...  
Keyword(s):  
Avian Influenza ◽  
Newcastle Disease ◽  
Adjuvant Activity ◽  
Infectious Bronchitis ◽  
Sargassum Pallidum ◽  
Inactivated Vaccines

scholarly journals Dietary Aureomycin Chlortetracycline and Immune Response to Newcastle Disease and Infectious Bronchitis

1955 ◽  
Vol 34 (3) ◽  
pp. 554-559 ◽  
Author(s):  
F.S. Markham ◽  
R.J. Price ◽  
K. Seeger ◽  
R. White-Stevens
Keyword(s):  
Immune Response ◽  
Newcastle Disease ◽  
Infectious Bronchitis

scholarly journals Optimization of Human Immunodeficiency Virus Gag Expression by Newcastle Disease Virus Vectors for the Induction of Potent Immune Responses

2008 ◽  
Vol 83 (2) ◽  
pp. 584-597 ◽  
Author(s):  
Elena Carnero ◽  
Wenjing Li ◽  
Antonio V. Borderia ◽  
Bruno Moltedo ◽  
Thomas Moran ◽  
...  
Keyword(s):  
Immune Response ◽  
Human Immunodeficiency Virus ◽  
Immune Responses ◽  
Newcastle Disease Virus ◽  
Disease Virus ◽  
Newcastle Disease ◽  
Insertion Site ◽  
Gag Protein ◽  
Immunodeficiency Virus

ABSTRACT One attractive strategy for the development of a human immunodeficiency virus (HIV) vaccine is the use of viral vectors with a proven safety profile and an absence of preexisting immunity in humans, such as Newcastle disease virus (NDV). Several NDV vaccine vectors have been generated, and their immunogenicities have been investigated with different animal models. However, a systematic study to evaluate the optimal insertion site of the foreign antigens into NDV that results in enhanced immune responses specific to the antigen has not yet been conducted. In this article, we describe the ability of NDV expressing HIV Gag to generate a Gag-specific immune response in mice. We also have determined the optimal insertion site into the NDV genome by generating recombinant NDV-HIVGag viruses in which HIV gag was located at different transcriptional positions throughout the NDV viral genome. All recombinant viruses were viable, grew to similar titers in embryonated chicken eggs, and expressed Gag in a stable manner. Our in vivo experiments revealed that higher HIV Gag protein expression positively correlates with an enhanced CD8+ T-cell-mediated immune response and protective immunity against challenge with vaccinia virus expressing HIV Gag. We also inserted a codon-optimized version of HIV gag in the described best location, between the P and M genes. Virus expressing the codon-optimized version of HIV gag induced a higher expression of the protein and an enhanced immune response against HIV Gag in mice. These results indicate that strategies directed toward increasing antigen expression by NDV result in enhanced immunogenicity and vaccine efficacy.

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