scholarly journals Systematic Framework toward a Highly Reliable Approach in Metal Accounting

Author(s):  
Yousef Ghorbani ◽  
Glen T. Nwaila ◽  
Munyar Chirisa
Keyword(s):  
2019 ◽  
Vol 13 (2) ◽  
pp. 144-152 ◽  
Author(s):  
Roni Reiter-Palmon ◽  
Boris Forthmann ◽  
Baptiste Barbot

Author(s):  
Chung-Kuan Cheng ◽  
Andrew B. Kahng ◽  
Hayoung Kim ◽  
Minsoo Kim ◽  
Daeyeal Lee ◽  
...  
Keyword(s):  

2016 ◽  
Vol 25 (4) ◽  
pp. 49-61
Author(s):  
Herlander Mata-Lima ◽  
Fernando Morgado-Dias ◽  
Marina Carrato Galuzzi da Silva ◽  
Kelly Alcântara ◽  
José António Almeida

2016 ◽  
Vol 2016 ◽  
pp. 1-17 ◽  
Author(s):  
Erkhembayar Jadamba ◽  
Miyoung Shin

Drug repositioning offers new clinical indications for old drugs. Recently, many computational approaches have been developed to repurpose marketed drugs in human diseases by mining various of biological data including disease expression profiles, pathways, drug phenotype expression profiles, and chemical structure data. However, despite encouraging results, a comprehensive and efficient computational drug repositioning approach is needed that includes the high-level integration of available resources. In this study, we propose a systematic framework employing experimental genomic knowledge and pharmaceutical knowledge to reposition drugs for a specific disease. Specifically, we first obtain experimental genomic knowledge from disease gene expression profiles and pharmaceutical knowledge from drug phenotype expression profiles and construct a pathway-drug network representing a priori known associations between drugs and pathways. To discover promising candidates for drug repositioning, we initialize node labels for the pathway-drug network using identified disease pathways and known drugs associated with the phenotype of interest and perform network propagation in a semisupervised manner. To evaluate our method, we conducted some experiments to reposition 1309 drugs based on four different breast cancer datasets and verified the results of promising candidate drugs for breast cancer by a two-step validation procedure. Consequently, our experimental results showed that the proposed framework is quite useful approach to discover promising candidates for breast cancer treatment.


2019 ◽  
Vol 46 (6) ◽  
pp. 511-521
Author(s):  
Lian Gu ◽  
Tae J. Kwon ◽  
Tony Z. Qiu

In winter, it is critical for cold regions to have a full understanding of the spatial variation of road surface conditions such that hot spots (e.g., black ice) can be identified for an effective mobilization of winter road maintenance operations. Acknowledging the limitations in present study, this paper proposes a systematic framework to estimate road surface temperature (RST) via the geographic information system (GIS). The proposed method uses a robust regression kriging method to take account for various geographical factors that may affect the variation of RST. A case study of highway segments in Alberta, Canada is used to demonstrate the feasibility and applicability of the method proposed herein. The findings of this study suggest that the geostatistical modelling framework proposed in this paper can accurately estimate RST with help of various covariates included in the model and further promote the possibility of continuous monitoring and visualization of road surface conditions.


2016 ◽  
Vol 13 (115) ◽  
pp. 20150936 ◽  
Author(s):  
Arnold J. T. M. Mathijssen ◽  
Amin Doostmohammadi ◽  
Julia M. Yeomans ◽  
Tyler N. Shendruk

Biological flows over surfaces and interfaces can result in accumulation hotspots or depleted voids of microorganisms in natural environments. Apprehending the mechanisms that lead to such distributions is essential for understanding biofilm initiation. Using a systematic framework, we resolve the dynamics and statistics of swimming microbes within flowing films, considering the impact of confinement through steric and hydrodynamic interactions, flow and motility, along with Brownian and run–tumble fluctuations. Micro-swimmers can be peeled off the solid wall above a critical flow strength. However, the interplay of flow and fluctuations causes organisms to migrate back towards the wall above a secondary critical value. Hence, faster flows may not always be the most efficacious strategy to discourage biofilm initiation. Moreover, we find run–tumble dynamics commonly used by flagellated microbes to be an intrinsically more successful strategy to escape from boundaries than equivalent levels of enhanced Brownian noise in ciliated organisms.


2021 ◽  
Vol 118 (31) ◽  
pp. e2022472118
Author(s):  
Andrew J. Stier ◽  
Kathryn E. Schertz ◽  
Nak Won Rim ◽  
Carlos Cardenas-Iniguez ◽  
Benjamin B. Lahey ◽  
...  

It is commonly assumed that cities are detrimental to mental health. However, the evidence remains inconsistent and at most, makes the case for differences between rural and urban environments as a whole. Here, we propose a model of depression driven by an individual’s accumulated experience mediated by social networks. The connection between observed systematic variations in socioeconomic networks and built environments with city size provides a link between urbanization and mental health. Surprisingly, this model predicts lower depression rates in larger cities. We confirm this prediction for US cities using four independent datasets. These results are consistent with other behaviors associated with denser socioeconomic networks and suggest that larger cities provide a buffer against depression. This approach introduces a systematic framework for conceptualizing and modeling mental health in complex physical and social networks, producing testable predictions for environmental and social determinants of mental health also applicable to other psychopathologies.


Author(s):  
Leyre Escajedo San Epifanio

Recurriendo a García Pelayo, son bastantes los elementos de los actuales sistemas democráticos en los que cabría hallar, sobre todo en lo formal, una cierta homogeneidad armónica con sus precedentes históricos o referentes de Derecho comparado. De todos ellos, sin embargo, parece que la inviolabilidad regia es uno de los pocos —sino el único— de los elementos en los que se duda si las previsiones constitucionales deben interpretarse dentro del marco sistemático que les da cobijo o si, por el contrario, cabe la posibilidad de eludir ese marco y basarse en antecedentes históricos o referentes comparados para proceder a su interpretación. Pareciera que, al menos respecto del estatuto regio, se defiende no sólo una cierta suprapositividad sino, incluso, la supuesta existencia anclaje preconstitucional inamovible, ubicado lejos del alcance de la soberanía que reside en el pueblo. Desde la perspectiva del Derecho constitucional, aunque sin perder de vista la historiografía y, hasta cierto punto, la Psicología política, este trabajo aborda el estudio de dicho fenómeno, procediendo a una revisión histórica de la inviolabilidad regia y al análisis de las interpretaciones contemporáneas de la misma.Recalling García Pelayo, there are quite a few elements of the current democratic systems in which it would be possible to find, especially in formal terms, a certain harmonic homogeneity with their historical precedents or comparative law references. Of all of them, however, it seems that royal inviolability is one of the few —if not the only one— of the elements in which it is doubted whether the current constitutional provisions should be interpreted within the systematic framework that shelters them or whether, on the contrary, it is possible to circumvent this framework and rely on historical antecedents or comparative references to proceed with its interpretation. It would seem that, at least with respect to the royal statute, not only a certain suprapositive nature is defended, but even the supposed existence of an immovable pre-constitutional anchor, situated far from the reach of the sovereignty that resides in the people. From the perspective of Constitutional law, although without losing sight of historiography and, to a certain extent, Political psychology, this work addresses the study of this phenomenon, proceeding to a historical review of royal inviolability and an analysis of contemporary interpretations of it.


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