scholarly journals A short-term ingestion of fructo-oligosaccharides increases immunoglobulin A and mucin concentrations in the rat cecum, but the effects are attenuated with the prolonged ingestion

2014 ◽  
Vol 78 (9) ◽  
pp. 1592-1602 ◽  
Author(s):  
Mika Komura ◽  
Tomonori Fukuta ◽  
Tomomi Genda ◽  
Shingo Hino ◽  
Seiichiro Aoe ◽  
...  
Keyword(s):  
Immunoglobulin A ◽  
Short Term ◽  
Rat Cecum

scholarly journals Targeted Marine Phytoplankton Supplementation Improves Recovery During Intensified Training

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1772-1772
Author(s):  
Jacob Wilson ◽  
Matthew Stefan ◽  
Matthew Sharp ◽  
Nicholous Book ◽  
Dallen Reber ◽  
...  
Keyword(s):  
Immune Function ◽  
Repeated Measures ◽  
Essential Fatty Acids ◽  
Immunoglobulin A ◽  
Marine Phytoplankton ◽  
Short Term ◽  
Intensive Training ◽  
Explosive Strength ◽  
Funding Sources ◽  
Tetraselmis Chuii

Abstract Objectives The purpose of this study was to investigate marine phytoplankton supplementation (Microalgae Tetraselmis chuii, Oceanix™, OCX) that is rich in antioxidant enzymes, essential fatty acids, vitamins, amino acids and minerals on Explosive Strength (ES), and Immune Function during short term intensive training. Methods Trained male and female subjects were randomly divided into a microcrystalline cellulose based placebo (PLA, ) or Oceanix™ (OCX) (25 mg per day) condition for 14 days. Subjects were tested at baseline and then placed on an intensified based resistance training protocol using multiple sets to volitional failure over the course of 5 days and retested 24 and 48 hours following. Explosive strength, measured as rate of force development during an isometric mid thigh pull was assessed. Immune function was determined using salivary immunoglobulin-A (IgA). Repeated measures ANOVA and Tukey post hoc analysis were used to assess differences. Results Explosive Strength was significantly lower at 24 (-62%) and 48 (-78%) hours in the PLA but not OCX compared to pre levels (P < 0.05). Additionally, the absolute mean difference in Explosive Strength from Pre to 48hr-Post was significantly lower in PLA compared to OCX (P < 0.05), indicating greater recovery in OCX. Forty-eight hour post IgA levels decreased compared to Pre (P < 0.05, −178%) in the PLA but not OCX group. Conclusions Targeted marine phytoplankton supplementation (Oceanix™, OCX) improves short term recovery from short term intensive training. Funding Sources Lonza.

Prematch Salivary Secretory Immunoglobulin A in Soccer Players From the 2014 World Cup Qualifying Campaign

2015 ◽  
Vol 10 (3) ◽  
pp. 401-403 ◽  
Author(s):  
Ryland Morgans ◽  
Adam Owen ◽  
Dominic Doran ◽  
Barry Drust ◽  
James P. Morton
Keyword(s):  
Fluid Collection ◽  
Immunoglobulin A ◽  
Soccer Players ◽  
Repeated Measure ◽  
Training Period ◽  
Secretory Immunoglobulin A ◽  
Short Term ◽  
World Cup ◽  
Salivary Secretory Immunoglobulin A ◽  
Secretory Immunoglobulin

Purpose:To monitor resting salivary secretory immunoglobulin A (SIgA) levels in international soccer players during the short-term training period that precedes international match play.Methods:In a repeated-measure design, saliva samples were obtained from 13 outfield soccer players who participated in the training camps preceding 7 games (5 home and 2 away) of the 2014 FIFA World Cup qualifying campaign. Samples were obtained daily for 4 d preceding each game (and analyzed for SIgA using the IPRO oral-fluid-collection system) at match day minus 1 (MD-1), minus 2 (MD-2), minus 3 (MD-3), and minus 4 (MD-4).Results:SIgA displayed a progressive decline (P = .01) during the 4-d training period (MD-4, 365 ± 127 μg/mL; MD-3, 348 ± 154 μg/mL; MD-2, 290 ± 138 μg/mL; MD-1, 256 ± 90 μg/mL) such that MD-1 values were significantly lower (P = .01) than both MD-4 and MD-3. The 95% confidence intervals for the differences between MD-1 and MD-4 were –191 to –26 and between MD-1 and MD-3 were –155 to –28.Conclusions:Data demonstrate that a short-term soccer-training camp in preparation for international competition induces detectable perturbations to mucosal immunity. Future studies should monitor SIgA (as a practical and noninvasive measure of immunity) alongside internal and external measures of training load in an attempt to strategically individualize training and nutritional strategies that may support optimal preparation for high-level competition.

scholarly journals The Safety and Short-Term Efficacy of Aliskiren in the Treatment of Immunoglobulin A Nephropathy – A Randomized Cross-Over Study

PLoS ONE ◽  
2013 ◽  
Vol 8 (5) ◽  
pp. e62736 ◽  
Author(s):  
Cheuk-Chun Szeto ◽  
Bonnie Ching-Ha Kwan ◽  
Kai-Ming Chow ◽  
Chi-Bon Leung ◽  
Philip Kam-Tao Li
Keyword(s):  
Immunoglobulin A ◽  
Immunoglobulin A Nephropathy ◽  
Short Term ◽  
Term Efficacy

scholarly journals Current status of meningococcal group B vaccine candidates: capsular or noncapsular?

1994 ◽  
Vol 7 (4) ◽  
pp. 559-575 ◽  
Author(s):  
J Diaz Romero ◽  
I M Outschoorn
Keyword(s):  
Membrane Proteins ◽  
Outer Membrane ◽  
Capsular Polysaccharide ◽  
Outer Membrane Proteins ◽  
Immunoglobulin A ◽  
Current Status ◽  
Short Term ◽  
Meningococcal Group ◽  
Life Threatening ◽  
Group B

Meningococcal meningitis is a severe, life-threatening infection for which no adequate vaccine exists. Current vaccines, based on the group-specific capsular polysaccharides, provide short-term protection in adults against serogroups A and C but are ineffective in infants and do not induce protection against group B strains, the predominant cause of infection in western countries, because the purified serogroup B polysaccharide fails to elicit human bactericidal antibodies. Because of the poor immunogenicity of group B capsular polysaccharide, different noncapsular antigens have been considered for inclusion in a vaccine against this serogroup: outer membrane proteins, lipooligosaccharides, iron-regulated proteins, Lip, pili, CtrA, and the immunoglobulin A proteases. Alternatively, attempts to increase the immunogenicity of the capsular polysaccharide have been made by using noncovalent complexes with outer membrane proteins, chemical modifications, and structural analogs. Here, we review the strategies employed for the development of a vaccine for Neisseria meningitidis serogroup B; the difficulties associated with the different approaches are discussed.

The vermiform appendix: an immunological organ sustaining a microbiome inoculum

2019 ◽  
Vol 133 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Luis Vitetta ◽  
Jiezhong Chen ◽  
Stephen Clarke
Keyword(s):  
Lamina Propria ◽  
B Lymphocyte ◽  
Plasma Cells ◽  
Immunoglobulin A ◽  
Vermiform Appendix ◽  
Lymphoid Follicle ◽  
Proximal Colon ◽  
Intestinal Microbiome ◽  
Short Term ◽  
Intestinal Epithelia

AbstractThe hominoid vermiform appendix has been characterized as a diverticulum of the caecum and describes an entity at the juxtaposition of the colon in the confluence of tanias. The independent development of the lymphoid follicle centres of the appendix is progressed at birth in the presence of the intestinal commensal microbiome, an obligatory prompt for the diversification of intestinal and extra-intestinal mucosal immunological tissue. In the vermiform appendix, this activity is centred on further developing the inventory of primary antibodies and the maturation of T- and B-lymphocyte cells in the follicles within the lymphoid tissue. Furthermore, the columnar epithelia, enterocytes and goblet cells comprise the complement of cells that occupy the lamina propria and muscularis mucosae of the vermiform appendix’s mucosa, while macrophages and an abundance of immunoglobulin A and immunoglobulin G generating plasma cells seed the lamina propria. Intraepithelial immune cells consisting predominantly of specific CD8+ T regulatory lymphocytes occupy sites in the appendix analogous to those present in the intestinal epithelia of the caecal colon. The complement of bacterial genera concealed in the vermiform appendix is posited extant as a biofilm inoculum of the intestinal commensal microbiome. This facilitates re-inoculation of the proximal colon and to a lesser degree the terminal ilium post an intestinal perturbation such as occurs with daily lifestyle stressors, dietary choices and the short-term administration of antibiotics rather than an infectious fulminant colitis. A plausible appreciation results of the importance of multiple immunological aspects of a healthy vermiform appendix and the provision of a commensal biofilm to the gut that repairs a dysbiotic microbiome contributing to balancing intestinal pro- and anti-inflammatory activity for maintaining homeostasis in the gut. Since the composition of the gut microbiome can vary over the short-term and long-term, it is plausible that the appendix inoculum may be instrumental in maintaining the intestinal microbiome.

scholarly journals Interleukin-6-Deficient Mice Are Highly Susceptible to Giardia lamblia Infection but Exhibit Normal Intestinal Immunoglobulin A Responses against the Parasite

2003 ◽  
Vol 71 (3) ◽  
pp. 1569-1573 ◽  
Author(s):  
Marianne Bienz ◽  
Wen Juan Dai ◽  
Monika Welle ◽  
Bruno Gottstein ◽  
Norbert Müller
Keyword(s):  
Interleukin 6 ◽  
Giardia Lamblia ◽  
Immunoglobulin A ◽  
Mrna Levels ◽  
Short Term ◽  
Regulatory Processes ◽  
Reverse Transcription Pcr ◽  
Peripheral Lymph ◽  
Lymph Node Cells ◽  
Deficient Mice

ABSTRACT In the present study, interleukin-6 (IL-6)-deficient mice were infected with Giardia lamblia clone GS/M-83-H7. Murine IL-6 deficiency did not affect the synthesis of parasite-specific intestinal immunoglobulin A. However, in contrast to wild-type mice, IL-6-deficient animals were not able to control the acute phase of parasite infection. Reverse transcription-PCR-based quantitation of cytokine mRNA levels in peripheral lymph node cells exhibited a short-term up-regulation of IL-4 expression in IL-6-deficient mice that seemed to be associated with failure in controlling the parasite population. This observation suggests a further elucidation of IL-4-dependent, Th2-type regulatory processes regarding their potential to influence the course of G. lamblia infection in the experimental murine host.

Double-blind, controlled trial of short-term prednisone therapy in immunoglobulin A glomerulonephritis

1992 ◽  
Vol 121 (3) ◽  
pp. 474-477 ◽  
Author(s):  
Thomas R. Welch ◽  
Cheryl Fryer ◽  
Elizabeth Shely ◽  
David P. Witte ◽  
Monica Quinlan
Keyword(s):  
Controlled Trial ◽  
Immunoglobulin A ◽  
Short Term ◽  
Double Blind ◽  
Prednisone Therapy

scholarly journals Drinking functional coherent mineral water accompanies a strengthening of the very low frequency impact on heart rate variability, and mono and multifractal heart rhythm dynamics in healthy humans

2016 ◽  
Vol 6 (6) ◽  
pp. 388 ◽  
Author(s):  
Benny Johansson ◽  
Svetlana Sukhotskya
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Healthy Subjects ◽  
Mineral Water ◽  
Immunoglobulin A ◽  
Low Frequency ◽  
Heart Rhythm ◽  
Short Term ◽  
Very Low Frequency ◽  
Non Local

Background: Research on functional water has revealed its physiological functions and health-beneficial effects. Accordingly, this study explored the effects of drinking an average dietary volume of functional coherent mineral water (FCMW) on blood pressure, short-term cardiovascular variables, fractal heart rhythm dynamics, and salivary immunoglobulin A. Methods: Fifteen healthy subjects were randomized in a pre-post crossover design, selected the morning after an overnight fast. Short-term electrocardiography (ECG) was measured before and after drinking either control mineral water (CMW) or FCMW on two separate occasions. Saliva was collected for four minutes before the start of each ECG measurement. Blood pressure was monitored in five-minute intervals for one hour. Results: Drinking 100 ml of FCMW temporarily increased arterial blood pressure at 20 to 25 minutes in the 60 minutes post-drinking. Drinking CMW led to a significant reduction in the heart rate, while all-time domain and Power Spectral Density parameters (PSD) were unaffected. Consumption of FCMW resulted in a highly significant difference and decrease in heart rate, and an increase in NN interbeat intervals, and in two of the PSD parameters. A large increase in total power had a significant increasing effect on 2–3-minute oscillations of the very low frequency (VLF) power, indicating a specific change in the heartʼs intrinsic cardiac rhythm that is fundamental to health and well-being. An extension in mono and multifractal scaling of heart rate dynamics defines a healthy function and non-local adaptability, indicating a higher capacity to respond to unpredictable stimuli and stresses, a function which improves autonomic stability. The effect on the heart rate and VLF power suggest an efficient cellular metabolism and a stabilizing effect on mucosal immunoglobulin A. Conclusions: Functional coherent mineral water with an apparent non-local electromagnetic identity triggered in healthy subjects a sustainable sympathetic response in cardiac VLF power, which is considered an intrinsic health-promoting rhythm produced by the heart itself that accompanies adaptive mono and multifractal heart rhythm dynamics. Keywords: functional water, VLF-power, heart rate variability, fractal scaling, health improvement 

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