Vanillic acid in Panax ginseng root extract inhibits melanogenesis in B16F10 cells via inhibition of the NO/PKG signaling pathway

Background: Unexplained fatigue is a common complaint. When underlying disease causes have been eliminated, lifestyle measures and supplementation can be indicated. Elaborating on clinical findings that G115®, a dry extract from the root of Panax ginseng, combined with vitamins and minerals could alleviate fatigue, this open label study aimed at assessing its effect on perceived fatigue and energy. Methods: Healthy adults self-reporting fatigue (n = 103) completed the Multidimensional Fatigue Inventory questionnaire. They rated their perceptions of mental and physical fatigue, energy, performance, and stress at baseline and 15, 30, 60 and 90 days after a daily intake of 40 mg G115® formulated with vitamins and minerals. Results: Compared with baseline values, mean self-perception of general fatigue was reduced by −7.55 units [95% CI: −8.44; −6.66] (−41.8%, p < 0.0001) at 90 days. All assessed perception ratings (mental and physical fatigue, reduced activity and motivation, performance, and stress) were significantly and steadily improved from two weeks after supplementation up to study’s end. Overall satisfaction with the ability of the product to reduce fatigue reached 85% at Day 90. Conclusion: Daily intake with G115® extract formulated with vitamins and minerals suggests an improvement of self-perception of fatigue and energy in a fatigued adult population.

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Neuroprotective effect of a ginseng (Panax ginseng) root extract on astrocytes primary culture

Journal of Ethnopharmacology ◽

10.1016/j.jep.2007.03.010 ◽

2007 ◽

Vol 112 (2) ◽

pp. 262-270 ◽

Cited By ~ 41

Author(s):

M.V. Naval ◽

M.P. Gómez-Serranillos ◽

M.E. Carretero ◽

A.M. Villar

Keyword(s):

Primary Culture ◽

Panax Ginseng ◽

Neuroprotective Effect ◽

Ginseng Root ◽

Root Extract

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MASKULINISASI IKAN CUPANG (Betta sp.) MENGGUNAKAN EKSTRAK AKAR GINSENG (Panax sp.)

Jurnal Akuakultur Rawa Indonesia ◽

10.36706/jari.v5i1.5799 ◽

2018 ◽

Vol 5 (1) ◽

pp. 1-12

Author(s):

Asrul . Ferdian ◽

Muslim . ◽

Mirna Fitrani

Keyword(s):

Survival Rate ◽

Panax Ginseng ◽

Fish Larvae ◽

Ginseng Root ◽

Root Extract ◽

Quality Of Water ◽

Randomized Design ◽

Completely Randomized Design

ABSTRACT The use of extract root ginseng in the process of Betta fish masculinization is expected to increase the testosterone. The purpose of this research is to determine the effect ginseng root extract to the percentage of the male betta fish by masculinization. This study has been conducted at the Basic Aquaculture Laboratory, Faculty of Agriculture, Sriwijaya University. This study use a completely randomized design with 4 treatments and 3 replications. The treatments in this research was betta fish larvae aged 7 days that submersed on ginseng root extract media with different concentration for 8 hours. The treatment were the addition of ginseng root extract as much as 1 mg/L (P1), 2 mg/L (P2), 3 mg/L (P3), 4 mg/L (P4) and without ginseng root extract addition as control (P0). Parameters observed consist of percentage of betta fish male, survival rate and quality of water. The result of this research shows that the addition of extract panax ginseng with difference concentration has significant effect to male betta fish percentage, but there is no a significant effect on survival rate. Treatment P3 with concentration 3 mg/L is the best result, it produced 95.05% of male betta fish after immersion for 8 hours. Keywords : Betta fish, Ginseng root extract, Immersion, Masculinization

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