Performance-based and parent ratings of attention in children treated for a brain tumor: The significance of radiation therapy and tumor location on outcome

2017 ◽  
Vol 24 (3) ◽  
pp. 413-425 ◽  
Author(s):  
Kimberly P. Raghubar ◽  
E. Mark Mahone ◽  
Keith Owen Yeates ◽  
M. Douglas Ris
Keyword(s):  
Radiation Therapy ◽  
Brain Tumor ◽  
Tumor Location ◽  
Parent Ratings

RESULTS OF TREATMENT OF LOCALLY RECURRING SOFT TISSUES SARCOMAS OF EXTREMITIES

2018 ◽  
Vol 64 (3) ◽  
pp. 408-413
Author(s):  
Grigoriy Zinovev ◽  
Georgiy Gafton ◽  
Sergey Novikov ◽  
Ivan Gafton ◽  
Yekaterina Busko ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Soft Tissues ◽  
Cox Regression ◽  
Disease Free Survival ◽  
Tumor Location ◽  
Long Term Results ◽  
Clinical Feature ◽  
National Medical ◽  
Results Of Treatment ◽  
Kaplan Meier

Background: The most striking clinical feature of soft tissues sarcomas (STS) is their ability to recur. At present disputes about the clinical and morphological factors of STS recurrence such as the degree of malignancy, size, location, depth of tumor location, patient’s age and the presence of previous relapses in the anamnesis do not subside. It also requires clarification of the effect of the volume of tissues removed on the long-term results of treatment of STS as well as indications for the application of various regimes of remote radiation therapy. Materials and methods: Of 1802 registered cases of STS of extremities at the N.N. Petrov National Medical Research Center of Oncology from 2004 to 2016 there were selected data on 213 patients who suffered from at least one relapse of the disease. There was performed an assessment of overall, non-metastatic and disease-free survival using a single-factor (the Kaplan-Meier method) and multivariate analysis (the Cox regression model). Conclusion: The detection of various prognostic factors of locally recurrent STS allows determining the necessary treatment tactics (the vastness and traumatism of surgery and the advisability of radiation therapy).

Long-term outcomes in children with glioblastoma

2010 ◽  
Vol 6 (2) ◽  
pp. 145-149 ◽  
Author(s):  
Kyung Sun Song ◽  
Ji Hoon Phi ◽  
Byung-Kyu Cho ◽  
Kyu-Chang Wang ◽  
Ji Yeoun Lee ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Progression Free Survival ◽  
Radical Resection ◽  
Tumor Location ◽  
Recurrent Glioblastoma ◽  
Subtotal Resection ◽  
Long Term Outcomes ◽  
Term Outcome ◽  
Long Term Outcome

Object Glioblastoma is the most common primary malignant brain tumor; however, glioblastoma in children is less common than in adults, and little is known about its clinical outcome in children. The authors evaluated the long-term outcome of glioblastoma in children. Methods Twenty-seven children were confirmed to have harbored a glioblastoma between 1985 and 2007. The clinical features and treatment outcomes were reviewed retrospectively. All patients underwent resection; complete resection was performed in 12 patients (44%), subtotal resection in 12 patients (44%), and biopsy in 3 patients (11%). Twenty-four patients (89%) had radiation therapy, and 14 (52%) patients received chemotherapy plus radiation therapy. Among the latter, 5 patients had radiation therapy concurrent with temozolomide chemotherapy. Four patients with small-size recurrent glioblastoma received stereotactic radiosurgery. Results The median overall survival (OS) was 43 months, and the median progression-free survival was 12 months. The OS rate was 67% at 1 year, 52% at 2 years, and 40% at 5 years. The median OS was significantly associated with tumor location (52 months for superficially located tumors vs 7 months for deeply located tumors; p = 0.017) and extent of removal (106 months for completely resected tumors vs 11 months for incompletely resected tumors; p < 0.0001). Conclusions The prognosis of glioblastoma is better in children than in adults. Radical resection followed by concurrent chemoradiation therapy may be the initial treatment of choice.

Diagnostic accuracy of 11C-methionine PET in detecting neuropathologically confirmed recurrent brain tumor after radiation therapy

2017 ◽  
Vol 32 (2) ◽  
pp. 132-141 ◽  
Author(s):  
Annika Kits ◽  
Heather Martin ◽  
Alejandro Sanchez-Crespo ◽  
Anna F. Delgado
Keyword(s):  
Radiation Therapy ◽  
Brain Tumor ◽  
Diagnostic Accuracy ◽  
Recurrent Brain Tumor

Influence of tumor location on the intensity-modulated radiation therapy plan of helical tomotherapy

2017 ◽  
Vol 42 (4) ◽  
pp. 334-340 ◽  
Author(s):  
Yingjie Xu ◽  
Hui Yan ◽  
Zhihui Hu ◽  
Pan Ma ◽  
Kuo Men ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Helical Tomotherapy ◽  
Intensity Modulated Radiation Therapy ◽  
Tumor Location ◽  
Intensity Modulated

Radiation therapy of brain tumor

1980 ◽  
Vol 16 (1) ◽  
pp. 259
Author(s):  
KJ Sung ◽  
DH Lee ◽  
CY Park
Keyword(s):  
Radiation Therapy ◽  
Brain Tumor

scholarly journals POSSIBILITIES OF USING CRYOSURGICAL METHOD IN TREATMENT OF DEPTH BRAIN TUMORS

2016 ◽  
Vol 175 (1) ◽  
pp. 11-17
Author(s):  
A. I. Kholyavin ◽  
V. B. Nizkovolos ◽  
B. V. Martynov ◽  
D. V. Svistov ◽  
A. D. Anichkov ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Radiation Therapy ◽  
Brain Tumor ◽  
Surgical Treatment ◽  
Surgical Removal ◽  
Tumor Localization ◽  
Brain Areas ◽  
Pet Ct ◽  
Stereotactic Guidance

Cryosurgical method is used in treatment of patients with glial tumors which localized in depth and functionally meaningful brain areas. These patients are generally considered as inoperable and receive conservative treatment. Their prognosis has become worse as compared to the patients whose brain tumor is available for surgical removal. The authors used a multiway stereotactic destruction of tumors by cryosurgical cannula, which is inserted in bone cutter opening using manipulator. MR-imaging and PET/CT of brain were applied for stereotactic guidance. The majority of patients who underwent this operation didn’t noticed any loss of quality of life. The rates of survival were higher than corresponding indicators for patients who were treated only by chemo- or radiation therapy and the rates were equal to the patients underwent the radical operations. Thus, the multiway stereotactic cryodestruction is a new, safe and effective method of surgical treatment for the patients with tumor localization in such areas, that their location blocked an application of traditional surgical removal by open method.

scholarly journals OTHR-02. MULTIMODALITY TREATMENT FOR CHILDREN WITH CENTRAL NERVOUS SYSTEM (CNS) TUMOR IN OUR INSTITUTE

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii423-iii423
Author(s):  
Mari Sasano ◽  
Koichiro Sumi ◽  
Nobuhiro Moro ◽  
Hideki Oshima ◽  
Maiko Hirai ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Brain Tumor ◽  
Malignant Tumors ◽  
Treatment Plan ◽  
Pediatric Brain Tumor ◽  
Multimodality Treatment ◽  
Whole Body ◽  
Cell Transplant ◽  
Treatment Team ◽  
Cns Tumor

Abstract BACKGROUND The brain tumor has a highest mortality rate among childhood malignant tumors. Development of peripheral blood stem cell transplant combined chemotherapy and radiation therapy improved the survival rate of patients with pediatric brain tumor drastically late years. Because of its complicated treatment plan, neurosurgeons cannot readily manage these aggressive therapies which require minute whole body control including prevention of lethal infection due to bone marrow suppression. Even if such treatment is effective and patient survives, the aftereffects may reduce patient’s QOL. PURPOSE We report outcomes of the patients with CNS tumor after multimodality treatment. In addition, we introduce the activity contents by the in-hospital children brain tumor multi-disciplinary medical treatment team organized in March 2016. METHODS We retrospectively reviewed 29 patients (under 15 years old) diagnosed as CNS tumors with total of 43 tumor surgeries between January 2001 and December 2019. RESULTS The histopathological diagnoses were 7 germ cell tumor, 7 astrocytic tumor, 4 ependymal tumor, 4 medulloblastoma, 2 craniopharyngioma, 2 AT/RT and 3 others. The mean age at first surgery was 7.4 y.o. (range: 0.3–14.8). Both chemotherapy and radiation therapy were performed in 22 cases out of 29. There were 15 survivors (11 ambulant, 3 W/C, 1 bedridden), 12 deaths, 2 lost follow-ups. Mean follow-up period was 66 months (range: 1–206). CONCLUSION To improve outcomes, we hold on a regular basis of team meeting, discuss treatment plan, and share information. Recently, we also care issues of the patients, such as fertility and palliative medicine.

scholarly journals TR-04 * NANOPARTICLE siRNA DELIVERY VEHICLES INHIBIT DNA REPAIR AND SENSITIZE PEDIATRIC BRAIN TUMOR CELLS TO RADIATION THERAPY

2015 ◽  
Vol 17 (suppl 3) ◽  
pp. iii37-iii37
Author(s):  
F. Kievit ◽  
Z. Stephen ◽  
K. Wang ◽  
C. Dayringer ◽  
J. Silber ◽  
...  
Keyword(s):  
Dna Repair ◽  
Radiation Therapy ◽  
Brain Tumor ◽  
Tumor Cells ◽  
Sirna Delivery ◽  
Pediatric Brain Tumor ◽  
Brain Tumor Cells ◽  
Delivery Vehicles ◽  
Pediatric Brain

Radiation Therapy in the Treatment of Partially Resected Meningiomas

Neurosurgery ◽  
1987 ◽  
Vol 20 (4) ◽  
pp. 525-528 ◽  
Author(s):  
Nicholas M. Barbaro ◽  
Philip H. Gutin ◽  
Charles B. Wilson ◽  
Glenn E. Sheline ◽  
Edwin B. Boldrey ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
San Francisco ◽  
Tumor Location ◽  
Convincing Evidence ◽  
Subtotal Resection ◽  
Intracranial Meningioma ◽  
Total Resection ◽  
Female Ratio ◽  
Time To Recurrence ◽  
Male Female Ratio

Abstract To address the question of whether radiation therapy is beneficial in the management of partially resected meningiomas, we reviewed the records of all patients admitted to the University of California, San Francisco, between 1968 and 1978 who had a diagnosis of intracranial meningioma. The patients were divided into three groups: 51 patients had gross total resection and did not receive radiation therapy, 30 patients had subtotal resection and no radiation therapy, and 54 patients had subtotal resection followed by radiation therapy. The subtotal resection groups were similar in average age, male: female ratio, and tumor location, which allowed a valid comparison of the effects of irradiation. The recurrence rate in the total resection group was 4% (2 of 51 patients). Among patients in the subtotal resection groups, 60% of nonirradiated patients had a recurrence, compared with only 32% of the irradiated patients. The median time to recurrence was significantly longer in the irradiated group than in the nonirradiated group (125 vs. 66 months, P &lt; 0.05). There was no complication related to irradiation. These results provide convincing evidence that radiation therapy is beneficial in the treatment of partially resected meningiomas.

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