Effects of pre-exposure of mouse testis with low-dose 16O 8 ions or 60Co gamma -rays on sperm shape abnormalities, lipid peroxidation and superoxide dismutase (SOD) activity induced by subsequent high-dose irradiation

1998 ◽  
Vol 73 (2) ◽  
pp. 163-167 ◽  
Author(s):  
H. ZHANG R. L. ZHENG Z. Q. WEI W. J. L
Keyword(s):  
Lipid Peroxidation ◽  
Superoxide Dismutase ◽  
Gamma Rays ◽  
Low Dose ◽  
Mouse Testis ◽  
High Dose ◽  
Sod Activity ◽  
Dose Irradiation ◽  
60Co Gamma ◽  
60Co Gamma Rays

Celecoxib A Selective COX-2 Inhibitor Mitigates Fibrosis but not Pneumonitis Following Lung Irradiation: A Histopathological Study

2020 ◽  
Vol 15 (4) ◽  
pp. 351-357
Author(s):  
Rasoul Azmoonfar ◽  
Peyman Amini ◽  
Hana Saffar ◽  
Elahe Motevaseli ◽  
Ehsan Khodamoradi ◽  
...  
Keyword(s):  
Gamma Rays ◽  
Histopathological Study ◽  
High Dose ◽  
Vascular Changes ◽  
Important Target ◽  
60Co Gamma ◽  
Radiation Induced ◽  
Lung Irradiation ◽  
60Co Gamma Rays ◽  
Cox 2

Background: Lung is one of the radiosensitive and late responding organs, and is an important target for ionizing radiation. Radiation-induced pneumonitis and fibrosis are major consequences of lung exposure to a high dose of radiation and pose threats to the lives of exposed people. Mitigation of lung injury following an accidental radiation event or for patients with lung cancer is one of the most interesting issues in radiobiology. In the current study, we aimed to determine whether celecoxib, the most common cyclooxygenase-2 (COX-2) inhibitor, is able to mitigate pneumonitis and fibrosis following lung irradiation or not. Materials and methods: 20 male mice were assigned to 4 groups: control, celecoxib treatment, radiation, and radiation plus celecoxib. Irradiation was performed with a dose of 18 Gy cobalt-60 (60Co) gamma rays. Celecoxib treatment (50 mg/kg) started 24 h after irradiation and continued four times per week for 4 weeks. Results: Irradiation of lung led to remarkable infiltration of macrophages, lymphocytes, mast cells and neutrophils. Also, a mild increase in fibrosis markers including accumulation of collagen, and alveolar and vascular thickening, was observed. Post-exposure treatment with celecoxib was able to mitigate fibrosis as well as alveolar and vascular changes, however, it was unable to mitigate pneumonitis markers. Conclusion: Celecoxib showed that it may have an anti-fibrosis effect following exposure of mice lung to radiation, although it was unable to prevent pneumonitis.

Primary Explants of Human Uroepithelium Show an Unusual Response to Low-Dose Irradiation with Cobalt-60 Gamma Rays

1995 ◽  
Vol 142 (2) ◽  
pp. 181 ◽  
Author(s):  
C. Mothersill ◽  
J. Harney ◽  
F. Lyng ◽  
D. Cottell ◽  
K. Parsons ◽  
...  
Keyword(s):  
Gamma Rays ◽  
Low Dose ◽  
Dose Irradiation ◽  
Primary Explants

scholarly journals Activation of Biodefense System by Low-Dose Irradiation or Radon Inhalation and Its Applicable Possibility for Treatment of Diabetes and Hepatopathy

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Takahiro Kataoka ◽  
Kiyonori Yamaoka
Keyword(s):  
Liver Disease ◽  
Alloxan Diabetes ◽  
Low Dose ◽  
Oxygen Species ◽  
Sod Activity ◽  
Oxygen Stress ◽  
Dose Irradiation ◽  
Treatment Of Diabetes ◽  
Radon Inhalation ◽  
Nonalcoholic Liver Disease

Adequate oxygen stress induced by low-dose irradiation activates biodefense system, such as induction of the synthesis of superoxide dismutase (SOD) and glutathione peroxidase. We studied the possibility for alleviation of oxidative damage, such as diabetes and nonalcoholic liver disease. Results show that low-dose -irradiation increases SOD activity and protects against alloxan diabetes. Prior or post-low-dose X- or -irradiation increases antioxidative functions in livers and inhibits ferric nitrilotriacetate and carbon tetrachloride-induced (CCl4) hepatopathy. Moreover, radon inhalation also inhibits CCl4-induced hepatopathy. It is highly possible that low-dose irradiation including radon inhalation activates the biodefence systems and, therefore, contributes to preventing or reducing reactive oxygen species-related diabetes and nonalcoholic liver disease, which are thought to involve peroxidation.

Evaluation of physicochemical characteristics in cherry tomatoes irradiated with 60Co gamma-rays on post-harvest conservation

2020 ◽  
Vol 177 ◽  
pp. 109139
Author(s):  
Karla Ferreira Mendes ◽  
Kassio Ferreira Mendes ◽  
Sumaya Ferreira Guedes ◽  
Lucia Cristina Aparecida Santos Silva ◽  
Valter Arthur
Keyword(s):  
Gamma Rays ◽  
Physicochemical Characteristics ◽  
Post Harvest ◽  
60Co Gamma ◽  
60Co Gamma Rays ◽  
Cherry Tomatoes

Effect of human recombinant superoxide dismutase on canine myocardial infarction

1990 ◽  
Vol 258 (2) ◽  
pp. H369-H380 ◽  
Author(s):  
B. S. Patel ◽  
M. O. Jeroudi ◽  
P. G. O'Neill ◽  
R. Roberts ◽  
R. Bolli
Keyword(s):  
Superoxide Dismutase ◽  
Infarct Size ◽  
Low Dose ◽  
Coronary Occlusion ◽  
Plasma Concentrations ◽  
Control Group ◽  
High Dose ◽  
Collateral Flow ◽  
Tetrazolium Chloride ◽  
Arterial Blood

To determine whether human recombinant superoxide dismutase (h-SOD) produces sustained reduction of infarct size, anesthetized dogs underwent a 2-h coronary occlusion followed by either 48 or 4 h of reperfusion. In the 48-h study, dogs were randomized to three intravenous treatments: 1) “low-dose” h-SOD (2 mg/kg bolus 2 min before reperfusion followed by 4 mg/kg over 45 min), 2) “high-dose” h-SOD (8 mg/kg bolus 2 min before reperfusion followed by 8 mg/kg over 45 min), or 3) equivalent volumes of saline. In the 4-h study, dogs were randomized to high-dose h-SOD or saline. Occluded bed size was measured by postmortem perfusion and infarct size by triphenyl tetrazolium chloride staining and planimetry. Investigators performing the study and measuring infarct size were blinded to the treatment given. High plasma concentrations of h-SOD were present in the arterial blood of treated dogs in the early phase of reperfusion (greater than 60 and greater than 180 micrograms/ml in low- and high-dose groups, respectively). In both studies, control and treated groups were similar with respect to occluded bed size, collateral blood flow, and rate-pressure product during ischemia. In the 48-h study, infarct size, expressed as percent of occluded bed size, was 41.3 +/- 7.6% (mean +/- SE) in the control group, 37.1 +/- 7.2% in the low-dose h-SOD group, and 48.0 +/- 7.1% in the high-dose h-SOD group. In the 4-h study, infarct size was 30.6 +/- 4.9% in the control group and 31.5 +/- 9.6% in the high-dose h-SOD group. Analysis of the flow-infarct relationships confirmed that h-SOD did not reduce infarct size at any level of collateral flow in either the 48- or 4-h study. Recovery of regional myocardial function after reperfusion was also unaffected by h-SOD in both studies. Thus in this randomized blinded study, large doses of h-SOD given at the time of reperfusion failed to limit infarct size or enhance recovery of function, both early (4 h) and late (48 h) after reperfusion following a 2-h coronary occlusion.

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