scholarly journals Wound Healing in the Corneal Epithelium: Biological Mechanisms and Mathematical Models

1997 ◽  
Vol 1 (1) ◽  
pp. 13-23 ◽  
Author(s):  
Eamonn A. Gaffney ◽  
Philip K. Maini ◽  
Jonathan A. Sherratt ◽  
Paul D. Dale
Keyword(s):  
Wound Healing ◽  
Corneal Epithelium ◽  
Tear Film ◽  
Repair Process ◽  
Wound Healing Response ◽  
Exogenous Addition ◽  
Healing Wound ◽  
Experimental Approaches ◽  
Epidermal Growth

Corneal epithelium has a highly specialided wound-healing response. The biological aspects of this repair process are reviewed, and methods of modelling it mathematically are described. A model which focuses on the source of epidermal growth factor (EGF) within a healing wound id described. By considering mathematical representations of a number of possible source terms, it is shown that the EGF presents in the tear film is insufficient to explain the observed rate of healing, and experimental approaches are suggested for distinguishing between other sources. Also, the simulation of exogenous addition of EGF using the miodel is described. An issue that has been the subject of considerable debate in the literature is the role of eyeball curvature. The model is used to show that this curvature is not significant for either the speed or form of healing in the epithelium. In conclusion, a comparison is made between wound healing in the corneal epithelium with that in the epidermis of the skin. Possible diredtions for future modelling work are considered.

scholarly journals Role of Lumican in the Corneal Epithelium during Wound Healing

2000 ◽  
Vol 275 (4) ◽  
pp. 2607-2612 ◽  
Author(s):  
Shizuya Saika ◽  
Atsushi Shiraishi ◽  
Satoko Saika ◽  
Chia-Yang Liu ◽  
James L. Funderburgh ◽  
...  
Keyword(s):  
Wound Healing ◽  
Corneal Epithelium

scholarly journals Roles of Proteoglycans and Glycosaminoglycans in Wound Healing and Fibrosis

2015 ◽  
Vol 2015 ◽  
pp. 1-20 ◽  
Author(s):  
Shibnath Ghatak ◽  
Edward V. Maytin ◽  
Judith A. Mack ◽  
Vincent C. Hascall ◽  
Ilia Atanelishvili ◽  
...  
Keyword(s):  
Wound Healing ◽  
Blood Cells ◽  
White Blood Cells ◽  
Cell Types ◽  
Repair Process ◽  
Epithelial Layer ◽  
Extracellular Molecules ◽  
Living Tissues ◽  
Type Of Injury

A wound is a type of injury that damages living tissues. In this review, we will be referring mainly to healing responses in the organs including skin and the lungs.Fibrosisis a process of dysregulated extracellular matrix (ECM) production that leads to a dense and functionally abnormal connective tissue compartment (dermis). In tissues such as the skin, the repair of the dermis after wounding requires not only thefibroblaststhat produce the ECM molecules, but also the overlying epithelial layer (keratinocytes), theendothelial cells, andsmooth muscle cellsof the blood vessel and white blood cells such asneutrophilsandmacrophages, which together orchestrate the cytokine-mediated signaling and paracrine interactions that are required to regulate the proper extent and timing of the repair process. This review will focus on the importance of extracellular molecules in the microenvironment, primarily the proteoglycans and glycosaminoglycan hyaluronan, and their roles in wound healing. First, we will briefly summarize the physiological, cellular, and biochemical elements of wound healing, including the importance of cytokine cross-talk between cell types. Second, we will discuss the role of proteoglycans and hyaluronan in regulating these processes. Finally, approaches that utilize these concepts as potential therapies for fibrosis are discussed.

scholarly journals The complex role of Prostaglandin E2-EP receptor signaling in wound healing

2020 ◽  
Author(s):  
Kristy E. Gilman ◽  
Kirsten H. Limesand
Keyword(s):  
Wound Healing ◽  
G Protein ◽  
Lipid Mediators ◽  
G Protein Coupled Receptors ◽  
Prostaglandin E ◽  
Receptor Signaling ◽  
Wound Healing Response ◽  
Ep Receptor ◽  
G Protein Coupled

Prostaglandins are critical lipid mediators involved in the wound healing response, with prostaglandin E2 (PGE2) being the most complex and exhibiting the most diverse physiological outputs. PGE2 signals via four G-protein coupled receptors, termed EP-receptors 1-4, that induce distinct signaling pathways upon activation and lead to an array of different outputs. Recent studies examining the role of PGE2 and EP receptor signaling in wound healing following various forms of tissue damage are discussed in this review.

Proliferative Capacity of in Vitro Corneal Epithelium: Role of Acacia Honey in the Initial Step of Wound Healing

2014 ◽  
Vol 3 (2) ◽  
pp. 107-112
Author(s):  
Choy Ker-Woon ◽  
Norzana Abd Ghafar ◽  
Chua Kien Hui ◽  
Yasmin Anum Mohd Yusof ◽  
Ng Sook Luan
Keyword(s):  
Wound Healing ◽  
Corneal Epithelium ◽  
Initial Step ◽  
Proliferative Capacity ◽  
Acacia Honey

scholarly journals Role of early debridement in non-healing ulcer

2017 ◽  
Vol 4 (12) ◽  
pp. 3976
Author(s):  
Darshan Tote ◽  
Suhas Jajoo ◽  
Sachin Tote
Keyword(s):  
Wound Healing ◽  
Financial Burden ◽  
Complete Healing ◽  
Wound Management ◽  
Financial Loss ◽  
Healing Ulcer ◽  
Early Recovery ◽  
Healing Wound ◽  
Early Debridement

Background: Non-healing wound is a commonly encountered entity with a broader effect on both the sufferer and the treating doctor. Time taken in healing these wound is directly related to financial loss as well as loss of working hours, thus ultimately increasing the financial burden. Chronic wound has devitalized tissue at the base which is barrier to cell migration and acts as supportive environment for bacterial growth. Considering the effect of devitalized tissue on wound healing there lies importance of debridement in wound management. Debridement is an effective technique to achieve desirable wound bed preparation by removing the dead and devitalized tissue. Hence a study was conducted at a rural hospital with main aim to assess role of surgical sharp debridement in non-healing wound in complete healing or preparing wound for further definitive treatment.Methods: The study was conducted at AVBRH Sawangi (Meghe), Wardha. Random 50 patients of non-healing ulcer were selected for the study. One group was of early debridement while other group of dressing with moist dressing only. Wound were assessed for healing, wound contraction, scar quality at regular intervals. They were assessed for duration of wound to heal completely/ get ready for further intervention like SSG/ Flaps, Cost of treatment and Time taken by the patient to return back to work.Results: 36% of patients in moist dressing group heal completely by 4 weeks while 56% of patients in debridement group heal completely by 4 weeks. Early recovery leads to early normalcy so less loss of wages and thus making the group cost effective.Conclusions: Early debridement was found to be an effective tool in wound healing in non-healing ulcers.

042
Role of Erbb3 and Epidermal Growth Factor-Like Ligands on Wound Healing

2008 ◽  
Vol 13 (2) ◽  
pp. A4-A27
Author(s):  
M.I. Okwueze ◽  
N.L. Cardwell ◽  
A.C. Pollins ◽  
L.B. Nanney
Keyword(s):  
Wound Healing ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Epidermal Growth

Neutrophil function in the healing wound: adding insult to injury?

2004 ◽  
Vol 92 (08) ◽  
pp. 275-280 ◽  
Author(s):  
Julia Dovi ◽  
Anna Szpaderska ◽  
Luisa DiPietro
Keyword(s):  
Wound Healing ◽  
Innate Immune System ◽  
Functional Role ◽  
Wound Closure ◽  
Inflammatory Cells ◽  
Neutrophil Function ◽  
Innate Immune ◽  
Normal Wound Healing ◽  
Healing Wound

SummaryCells of the innate immune system, including neutrophils and macrophages, are a highly visible component of normal wound healing in adult mammals. The role of inflammatory cells in the healing wound has been widely investigated, and evidence for both positive and negative influences exists. Several recent investigations support the emerging paradigm that robust inflammation is detrimental to wound closure. This developing information suggests that the functional role of inflammatory cells in wound healing must be reevaluated.

Sign in / Sign up

Export Citation Format

Share Document