Negative Control of Cell Proliferation. Growth Arrest versus Apoptosis. Role of βGBP
1998 ◽
Vol 1
(3)
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pp. 169-173
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Keyword(s):
βGBP is a novel physiological negative growth regulator of the cell and a cytostatic factor.It is secreted by cells, and bybinding with high affinity to specific cell surface receptors. In normal cell surface receptors. In normal cells, βGBP physiologically controls transition from G0to G1and passage from late S phase to G2by modulating signalling cascades activated by tyrosine Kinase receptors and by affecting transcription events.As a cytostatic Factor βGBP has a marked growth inhibitory effect on a variety of tumours including leukaemias where growth arrest is followed by the activation of apoptotic pathways and cell death.
Keyword(s):
1983 ◽
Vol 71
(5)
◽
pp. 1431-1441
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Keyword(s):
2002 ◽
Vol 76
(9)
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pp. 4559-4566
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1998 ◽
Vol 75
(4)
◽
pp. 362-366
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Keyword(s):
Keyword(s):
1983 ◽
Vol 258
(22)
◽
pp. 13882-13889
2020 ◽
Vol 7
(1)
◽
pp. 143-165
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