Using peptides to promote delivery and improve anti-tumour efficacy of liposomal drug

2021 ◽  
pp. 1-33
Author(s):  
Joseph G. Altin ◽  
Yabing Zhao
Keyword(s):  
Liposomal Drug

Recent Advances in Novasome Formulation Technology

2014 ◽  
Vol 7 (2) ◽  
pp. 2407-2411
Author(s):  
J M Shah ◽  
N.H Shah ◽  
Hadiya P D
Keyword(s):  
Drug Delivery ◽  
Effective Means ◽  
Entrapment Efficiency ◽  
Bilayer Membrane ◽  
Water Soluble ◽  
Delivery Methods ◽  
Liposomal Drug ◽  
Pharmaceutical Technology ◽  
Insoluble Drugs ◽  
Novel Drug

Pharmaceutical technology has developed various newer modes of novel drug delivery aspects. Modifications in the previously existing drug delivery methods have led to various newly innovated technologies serving as a safe and effective means of improvement over the existing ones. Novasome technology is one of the new innovations of liposomes which have solved many of the problems related to liposomal drug delivery system. It offers a seven bilayer membrane which has the ability to incorporate both water soluble and insoluble drugs. It has an excellent entrapment efficiency which provides better medication. Formulation of novasomes is achieved in a high shear device. Due to its numerous advantages, novasomes have been used extensively in various fields like cosmetics, chemical, personal care, foods, pharmaceuticals and agrochemicals.

scholarly journals Formulations Based on Drug Loaded Aptamer-Conjugated Liposomes as a Viable Strategy for the Topical Treatment of Basal Cell Carcinoma—In Vitro Tests

Pharmaceutics ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 866
Author(s):  
Anca N. Cadinoiu ◽  
Delia M. Rata ◽  
Leonard I. Atanase ◽  
Cosmin T. Mihai ◽  
Simona E. Bacaita ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Topical Treatment ◽  
Skin Irritation ◽  
In Vitro Tests ◽  
Liposomal Drug ◽  
Liposomal Formulations ◽  
As1411 Aptamer

Topical liposomal drug formulations containing AS1411-aptamer conjugated liposomes were designed to deliver in a sustained way the 5-fluorouracil to the tumor site but also to increase the compliance of patients with basal cell carcinoma. The 5-fluorouracil penetrability efficiency through the Strat-M membrane and the skin irritation potential of the obtained topical liposomal formulations were evaluated in vitro and the Korsmeyer Peppas equation was considered as the most appropriate to model the drug release. Additionally, the efficiency of cytostatic activity for targeted antitumor therapy and the hemolytic capacity were performed in vitro. The obtained results showed that the optimal liposomal formulation is a crosslinked gel based on sodium alginate and hyaluronic acid containing AS1411-aptamer conjugated liposomes loaded with 5-fluorouracil, which appeared to have favorable biosafety effects and may be used as a new therapeutic approach for the topical treatment of basal cell carcinoma.

scholarly journals Carbohydrate‐Derived Metal‐Chelator‐Triggered Lipids for Liposomal Drug Delivery

2021 ◽  
Author(s):  
Thomas Holmstrøm ◽  
Mette Galsgaard Malle ◽  
Shunliang Wu ◽  
Knud Jørgen Jensen ◽  
Nikos S. Hatzakis ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Liposomal Drug ◽  
Metal Chelator ◽  
Liposomal Drug Delivery

scholarly journals Impact of Liposomal Drug Formulations on the RBCs Shape, Transmembrane Potential, and Mechanical Properties

2021 ◽  
Vol 22 (4) ◽  
pp. 1710
Author(s):  
Sylwia Cyboran-Mikołajczyk ◽  
Przemysław Sareło ◽  
Robert Pasławski ◽  
Urszula Pasławska ◽  
Magdalena Przybyło ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Side Effects ◽  
Blood Cells ◽  
Transmembrane Potential ◽  
Drug Formulations ◽  
Liposomal Drug ◽  
Irregular Shapes ◽  
Liposomal Formulations ◽  
Current Therapies ◽  
Negative Side Effects

Liposomal technologies are used in order to improve the effectiveness of current therapies or to reduce their negative side effects. However, the liposome–erythrocyte interaction during the intravenous administration of liposomal drug formulations may result in changes within the red blood cells (RBCs). In this study, it was shown that phosphatidylcholine-composed liposomal formulations of Photolon, used as a drug model, significantly influences the transmembrane potential, stiffness, as well as the shape of RBCs. These changes caused decreasing the number of stomatocytes and irregular shapes proportion within the cells exposed to liposomes. Thus, the reduction of anisocytosis was observed. Therefore, some nanodrugs in phosphatidylcholine liposomal formulation may have a beneficial effect on the survival time of erythrocytes.

Cationic derivative of polyprenol, a potential component of liposomal drug carriers, does not alter renal function in rats

2014 ◽  
Vol 116 (5) ◽  
pp. 659-662 ◽  
Author(s):  
Olga Gawrys ◽  
Krzysztof Hubert Olszyński ◽  
Katarzyna Gawarecka ◽  
Ewa Swiezewska ◽  
Tadeusz Chojnacki ◽  
...  
Keyword(s):  
Renal Function ◽  
Drug Carriers ◽  
Liposomal Drug ◽  
Potential Component

New Developments in Liposomal Drug Delivery

2015 ◽  
Vol 115 (19) ◽  
pp. 10938-10966 ◽  
Author(s):  
Bhushan S. Pattni ◽  
Vladimir V. Chupin ◽  
Vladimir P. Torchilin
Keyword(s):  
Drug Delivery ◽  
New Developments ◽  
Liposomal Drug ◽  
Liposomal Drug Delivery
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