Antioxidant enzyme activity and lipid peroxidation in liver of female rats co-exposed to lead and cadmium: Effects of vitamin E and Mn2+

2005 ◽  
Vol 39 (7) ◽  
pp. 707-712 ◽  
Author(s):  
Anilkumar Pillai ◽  
Sarita Gupta
Keyword(s):  
Lipid Peroxidation ◽  
Enzyme Activity ◽  
Vitamin E ◽  
Antioxidant Enzyme ◽  
Antioxidant Enzyme Activity ◽  
Female Rats ◽  
Lead And Cadmium

scholarly journals The Impact of a Diet Containing Sucrose and Systematically Repeated Starvation on the Oxidative Status of the Uterus and Ovary of Rats

Nutrients ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 1544 ◽  
Author(s):  
Joanna Sadowska ◽  
Wioleta Dudzińska ◽  
Ewa Skotnicka ◽  
Katarzyna Sielatycka ◽  
Izabela Daniel
Keyword(s):  
Enzyme Activity ◽  
Antioxidant Enzyme ◽  
Oxidative Status ◽  
Antioxidant Enzyme Activity ◽  
Female Rats ◽  
Egg Cell ◽  
Starvation Period ◽  
Fertility Disorders ◽  
The Impact ◽  
Cell Implantation

The effect of a sucrose diet and repeated one-day starvation on oxidative status in the ovary and uterus is still unknown. Our analysis focused on carbohydrate-lipid metabolism parameters and the changes in red blood cells, ovary and uterus superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) activities and malonylodialdehyde (MDA) concentration in rats fed with a diet containing 16% of sucrose and subjected to systematic one-day starvation when using such a diet. It was found that a diet with 16% sucrose contributed to the increase of antioxidant enzyme activity in the blood (GPx and CAT) and uterus (SOD), without changes in MDA concentrations, which indicates an increase in reactive oxygen species (ROS) concentration in these tissues, being balanced by an increase in antioxidant enzyme activity. The introduction of a regular one-day starvation period into the diet intensified oxidative stress and led to a redox imbalance in the reproductive tissues of female rats. This was manifested by higher GPx activity, lower CAT activity and higher MDA concentration in the uterus and lower GPx and CAT activities and lower MDA concentration in the ovaries. The observed changes may be the cause of fertility disorders and possible problems with fertilised egg cell implantation into the uterine tissue.

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