Insulin resistance and diabetes in hyperthyroidism: a possible role for oxygen and nitrogen reactive species

2019 ◽  
Vol 53 (3) ◽  
pp. 248-268 ◽  
Author(s):  
Paola Venditti ◽  
Tanea T. Reed ◽  
Victor M. Victor ◽  
Sergio Di Meo
2021 ◽  
Vol 165 ◽  
pp. 54
Author(s):  
Patricia de la Cruz-Ojeda ◽  
M. Ángeles Rodríguez-Hernández ◽  
Elena Navarro-Villarán ◽  
Paloma Gallego ◽  
Pavla Staňková ◽  
...  

1995 ◽  
Vol 78 (5) ◽  
pp. 1800-1805 ◽  
Author(s):  
J. Cifuentes ◽  
J. Ruiz-Oronoz ◽  
C. Myles ◽  
B. Nieves ◽  
W. A. Carlo ◽  
...  

Increased concentrations of partially reduced oxygen and nitrogen reactive species damage the alveolar epithelium and either cause or exacerbate surfactant deficiency. For this reason, there is a quest to identify surfactant replacement mixtures, which in addition to repleting depleted surfactant stores can also reduce the steady-state concentrations of reactive species in the alveolar space. Herein, we evaluated the ability of natural lung surfactant (NLS) and two mixtures (Exosurf and Survanta) used clinically for the correction of surfactant deficiency to scavenge hydroxyl radical-type species (.OH), generated either by the decomposition of peroxynitrite or by Fenton reagents (FeCl3 + H2O2). Exosurf or Survanta decreased .OH only when present at high lipid concentrations (6.5 mM). On the other hand, 40 microM of NLS decreased .OH concentrations from 75 +/- 2 to 53 +/- 2 microM (P < 0.05), most likely because of the interaction of .OH with protein sulfhydryl groups. Similarly, 40 microM of NLS incubated with a bolus of H2O2 (400 microM) decreased the H2O2 concentration in the supernatant by approximately 50%, due to the presence of catalase-type activity. In contrast to NLS, neither Exosurf nor Survanta scavenged H2O2, even when present at millimolar lipid concentrations. We concluded that Exosurf and Survanta contain limited antioxidant activity compared with NLS.


2011 ◽  
Vol 493-494 ◽  
pp. 896-901
Author(s):  
María Canillas ◽  
Ann Rajnicek ◽  
C. Rosero ◽  
Eva Chinarro ◽  
Berta Moreno

The biocompatibility of TiO2 is due to the activity that it shown in front of oxygen and nitrogen reactive species. Some authors suggest that the mechanism go through oxidation reduction reactions where changes of oxidation state in the Titanium and phases are involve. For this reason, Anderson-Magnelli phases could present scavenging activity. Moreover, these materials are use as electrodes and in that way are proposed as electrodes for study their scavenging mechanism by electrochemical methods.


2009 ◽  
Vol 12 (1) ◽  
pp. 175-183 ◽  
Author(s):  
Isabel F. Almeida ◽  
Eduarda Fernandes ◽  
José L.F.C. Lima ◽  
Patrícia Valentão ◽  
Paula B. Andrade ◽  
...  

2021 ◽  
Author(s):  
Ricardo Monteiro ◽  
Daniela Ribeiro ◽  
Mariana Lucas ◽  
Marisa Freitas ◽  
Catarina Correia ◽  
...  

2009 ◽  
Vol 105 (4) ◽  
pp. 222-227 ◽  
Author(s):  
Isabel F. Almeida ◽  
Eduarda Fernandes ◽  
José L.F.C. Lima ◽  
Paulo Cardoso Costa ◽  
Maria Fernanda Bahia

Sign in / Sign up

Export Citation Format

Share Document