Creative therapeutic interventions for clinicians to promote physical activity in older adults with a history of brain injury: a viewpoint

2020 ◽  
pp. 1-6
Author(s):  
Jenna Tucker ◽  
Ilana Beitscher ◽  
Thomas A. Koc Jr. ◽  
Gabriella Fama ◽  
Jinal Patel ◽  
...  
2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S483-S483
Author(s):  
Aparna Vadlamani ◽  
Jennifer Albrecht

Abstract Patient reported history of comorbid illness may be the only information available to the treatment team during an acute injury admission. Nevertheless, acute injury, particularly traumatic brain injury (TBI) which affects cognition, may decrease the patient’s ability to accurately report medical history. Thus, the objective of this study was to evaluate the accuracy of patient-reported comorbid illness burden compared to the patient’s Medicare administrative claims. Records of older adults treated for TBI at an urban level 1 trauma center 2006-2010 were linked to their Medicare administrative. Comorbidities were recorded in Medicare claims based on ICD9 codes and were reported in the trauma registry (TR) based on patient medical history recorded by a physician or nurse. Prevalence of each of the following comorbidities was calculated using information from the TR and claims: Alzheimer’s disease and related dementias, chronic kidney disease, COPD, heart failure, diabetes, depression, stroke, and hypertension. Sensitivity of each patient-reported comorbidity was calculated using Medicare claims as the gold standard. We identified patient factors associated with accurate self-report using logistic regression. Among 408 older adults with TBI that linked to their Medicare claims, prevalence of each comorbidity was higher in Medicare claims compared to the TR, except for hypertension. Sensitivity for detecting these comorbidities using the TR ranged from 2% to 68%, with the highest sensitivity observed for hypertension. Older age and race were predictors of less accurate reported medical history. Reconciling self-reported patient history of these comorbidities with those reported in claims can better inform decisions regarding treatment.


1997 ◽  
Vol 5 (2) ◽  
pp. 98-110 ◽  
Author(s):  
Christina L. Smith ◽  
Martha Storandt

Histories of competitive sports involvement, health beliefs, reasons for exercising, and personality were compared across three groups of older adults who varied according to involvement in physical activity. Based on questionnaire responses, 246 participants were classified as competitors, noncompetitors. or nonexercisers. Competitors exhibited a lifelong history of sports participation. Although nonexercisers and noncompetitors participated in sports during their childhood and teenage years, their involvement in competition decreased noticeably in their 20s and remained low throughout adulthood. Competitors rated exercise significantly more important than did nonexercisers and non-competitors and had more varied reasons for exercising. Nonexercisers considered reducing stress and improving mood to be less important reasons for exercising than competitors and noncompetitors. All three groups were found to possess high levels of positive and low levels of negative personality traits.


2020 ◽  
Vol 16 (S6) ◽  
Author(s):  
Stefanie Danielle Piña‐Escudero ◽  
Roberto de Jesús García Aviles ◽  
Anna H. Chodos ◽  
Christine S. Ritchie ◽  
Jose Alberto Avila

2019 ◽  
Vol 41 (15) ◽  
pp. 1490-1499 ◽  
Author(s):  
Kyuwoong Kim ◽  
Seulggie Choi ◽  
Seo Eun Hwang ◽  
Joung Sik Son ◽  
Jong-Koo Lee ◽  
...  

Abstract Aims Little is known about the association of changes in moderate to vigorous physical activity (MVPA) level with cardiovascular disease (CVD), especially in older adults whose ability to engage in frequent MVPA naturally wanes as they age. We aimed to examine the association of changes in MVPA and CVD in older adults. Methods and results In a nationwide cohort study of older adults aged 60 years or older, we identified more than 1.1 million subjects without previous history of CVD at baseline who underwent two consecutive national health screening from 2009 to 2012. We prospectively assessed the risk of CVD occurred between 2013 and 2016 according to changes in frequency of MVPA by initial MVPA status. Compared to those who were continuously physically inactive, those who increased their frequency of MVPA from physically inactive to 1–2 times per week [0.7/1000 person-years (PY) decrease in incidence rate (IR); adjusted hazard ratio (aHR) 0.95; 95% confidence interval (CI) 0.92–0.99], 3–4 times per week (1.5/1000 PY decrease in IR; aHR 0.89; 95% CI 0.84–0.94), ≥5 times per week (0.4/1000 PY decrease in IR; aHR 0.91; 95% CI 0.85–0.97) had a significantly reduced risk for total CVD (P for trend <0.001). Older adults who became physically inactive from engaging in more than 1–2 times of MVPA per week had a higher CVD risk compared to those who maintained their frequency of MVPA. Conclusion Among older adults, engaging in higher frequency of MVPA or maintaining MVPA level was associated with reduced risk of CVD.


2012 ◽  
Vol 11 (12) ◽  
pp. 1103-1112 ◽  
Author(s):  
Laura Moretti ◽  
Irene Cristofori ◽  
Starla M Weaver ◽  
Aileen Chau ◽  
Jaclyn N Portelli ◽  
...  

Neurology ◽  
2021 ◽  
pp. 10.1212/WNL.0000000000013229
Author(s):  
Alison E Fohner ◽  
Traci M Bartz ◽  
Russell P Tracy ◽  
Hieab H.H. Adams ◽  
Joshua C Bis ◽  
...  

BACKGROUND AND OBJECTIVES:Neurofilament light chain (NfL) in blood is a sensitive but non-specific marker of brain injury. This study sought to evaluate associations between NfL concentration and MRI findings of vascular brain injury in older adults.METHODS:A longitudinal cohort study included two cranial MRI scans performed about 5 years apart and assessed for white matter hyperintensities (WMH) and infarcts. About one year before their second MRI, 1,362 participants (median age 77 years and 61.4% women) without a history of TIA or stroke had measurement of four biomarkers: NfL, total tau, glial fibrillary acidic protein (GFAP), and ubiquitin carboxyl-terminal hydrolase L1. Most (n = 1,279) also had the first MRI scan, and some (n=633) had quantitative measurements of hippocampal and WMH. In primary analyses, we assessed associations of NfL with a 10-point white matter grade (WMG) and prevalent infarcts on second MRI and with worsening WMG and incident infarct comparing the two scans. A p-value <0.0125 (0.05/4) was considered significant for these analyses. We also assessed associations with hippocampal and WMH volume.RESULTS:In fully adjusted models, log2(NfL) concentration was associated with WMG (β=0.27; p=2.3x10-4) and worsening WMG (RR=1.24; p=0.0022), but less strongly with prevalent brain infarcts (RR=1.18; p=0.013) and not with incident brain infarcts (RR=1.18; p=0.18). Associations were also present with WMH volume (beta=2242.9, p=0.0036). For the other three biomarkers, the associations for log2(GFAP) concentration with WMG and worsening WMG were significant.DISCUSSION:Among older adults without a history of stroke, higher serum NfL concentration was associated with covert MRI findings of vascular brain injury, especially the burden of WMH and its worsening. Whether these results offer opportunities for the use of NfL as a non-invasive biomarker of WMH or to control vascular risk factors remains to be determined.


2020 ◽  
Author(s):  
Samantha Vervoordt ◽  
Peter Arnett ◽  
Christopher Gerald Engeland ◽  
Frank Hillary

Objective: To examine the relationship between depression and cognitive ability, genetic risk, and hippocampal differences in an older sample of adults with a history of traumatic brain injury (TBI). Method: 121 participants with a history of moderate to severe or complicated mild TBI were included. All participants underwent buccal swabs for genetic testing, a comprehensive neuropsychological battery, surveys, and 46 participants underwent an MRI scan. Results: APOE e4 carrier status significantly predicted clinically significant depressive symptomatology on the Geriatric Depression Scale (GDS) with an odds ratio of 3.63, and carriers presented with a higher mean GDS score. GDS was not predictive of scores on measures of executive function, list learning delayed recall, or retention. Although GDS score was initially associated with poorer semantic memory scores and poorer story memory delayed recall, this variance was accounted for by age and cognitive reserve. Higher GDS scores were also associated with decreased hippocampal volume. Conclusions: APOE carrier status was predictive of depression in a sample of older individuals with a history of TBI a mean of 10 years post-injury. Depressive symptoms were also associated with decreased hippocampal volume but did not predict cognitive deficits in the examined domains above and beyond the effects of age and cognitive reserve. These results indicate that despite the relationship between depression and biological risks for decline, depressive symptoms in older adults with msTBI may not lead to exacerbated cognitive decline, which is better predicted by other factors (e.g., cognitive reserve).


Sign in / Sign up

Export Citation Format

Share Document