What’s So Special about the Developing Immune System?

2008 ◽  
Vol 27 (2) ◽  
pp. 223-254 ◽  
Author(s):  
Leigh Ann Burns-Naas ◽  
Kenneth L. Hastings ◽  
Gregory S. Ladics ◽  
Susan L. Makris ◽  
George A. Parker ◽  
...  
Keyword(s):  
Immune System ◽  
Toxicity Testing ◽  
Life Stages ◽  
Significant Progress ◽  
Immune Development ◽  
Immune Parameters ◽  
Current State ◽  
State Of The Science ◽  
Developmental Immunotoxicity ◽  
Nonhuman Species

The evolution of the subdiscipline of developmental immunotoxicology (DIT) as it exists today has been shaped by significant regulatory pressures as well as key scientific advances. This review considers the role played by legislation to protect children’s health, and on the emergence of immunotoxcity and developmental immunotoxicity guidelines, as well as providing some context to the need for special attention on DIT by considering the evidence that the developing immune system may have unique susceptibilities when compared to the adult immune system. Understanding the full extent of this potential has been complicated by a paucity of data detailing the development of the immune system during critical life stages as well as by the complexities of comparisons across species. Notably, there are differences between humans and nonhuman species used in toxicity testing that include specific differences relative to the timing of the development of the immune system as well as more general anatomic differences, and these differences must be factored into the interpretation of DIT studies. Likewise, understanding how the timing of the immune development impacts on various immune parameters is critical to the design of DIT studies, parameters most extensively characterized to date in young adult animals. Other factors important to DIT, which are considered in this review, are the recognition that effects other than suppression (e.g., allergy and autoimmunity) are important; the need to improve our understanding of how to assess the potential for DIT in humans; and the role that pathology has played in DIT studies in test animals. The latter point receives special emphasis in this review because pathology evaluations have been a major component of standard nonclinical toxicology studies, and could serve an important role in studies to evaluate DIT. This possibility is very consistent with recommendations to incorporate a DIT evaluation into standard developmental and reproductive toxicology (DART) protocols. The overall objective of this review is to provide a ‘snapshot’ of the current state-of-the-science of DIT. Despite significant progress, DIT is still evolving and it is our hope that this review will advance the science.

Developmental immunotoxicology and risk assessment: a workshop summary

2002 ◽  
Vol 21 (9-10) ◽  
pp. 473-478 ◽  
Author(s):  
M P Holsapple
Keyword(s):  
Risk Assessment ◽  
Immune System ◽  
Environmental Protection Agency ◽  
Standard Procedure ◽  
Panel Discussion ◽  
Chemical Exposure ◽  
Technical Committee ◽  
Individual Species ◽  
Standard Practices ◽  
Developmental Immunotoxicity

A workshop entitled ‘Developmental Immunotoxicology and Risk Assessment’ was held on 12–13 June 2001, in Washington, DC. The workshop was organized jointly by the Immunotoxicology Technical Committee (ITC) of the International Life Sciences Institute's (ILSI) Health and Environmental Sciences Institute (HESI) with input from the U.S. Environmental Protection Agency (EPA). Growing public concern that early exposure of the developing immune system to immunotoxic compounds may cause significant or persistent postnatal immunosuppression prompted the workshop. The main goal of the workshop was to examine scientific questions that underlie developmental immunotoxicity tests and the interpretation of the results as they relate to human risk assessment. A second goal was to provide a framework, based on current scientific knowledge, for the development of meaningful testing guidelines. The workshop focused on a series of questions that included how to address critical windows of exposure, how to develop and apply more predictive endpoints, does early chemical exposure cause transient or permanent effects on the immune system, as well as other related questions. On the first day, experts were invited to give scientific presentations relating to comparative developmental immunology, models of immunosuppression, and the regulatory aspects of developmental immunotoxicology. The second day was devoted to a panel discussion that included all the speakers as well as meeting participants, which attempted to answer each of the specific questions raised at the workshop. In general, it was acknowledged that there are a variety of techniques available for assessing immunosuppression in adult animal models, but there is uncertainty about how to apply these to a developing animal, especially if the goal is to have some standard procedure that can be applied for regulatory risk assessment. It was pointed out that although we know a lot about the developing immune system of individual species, we do not know how to relate the significance of drug or chemical effects on these systems in terms of human hazard. Overall, the panel deemed the area of developmental immunotoxicity to be still in its infancy and outlined strategies that could lead to the development of standard practices.

AR- und VR-Brillen in der Fabrikplanung*/Current AR- and VR-glasses in factory planning

2018 ◽  
Vol 108 (04) ◽  
pp. 251-256
Author(s):  
U. Bracht ◽  
M. Schlegel
Keyword(s):  
Virtual Reality ◽  
Augmented Reality ◽  
Significant Progress ◽  
Factory Planning ◽  
Current State ◽  
Virtual And Augmented Reality ◽  
Stand Der Technik

Augmented- und Virtual-Reality-Brillen haben signifikante Fortschritte in ihrer technischen Leistungsfähigkeit gemacht. In diesem Fachartikel wird der aktuelle Stand der Technik von AR- und VR-Brillen beschrieben, die bisherigen Hemmnisse für die Verwendung in der Fabrikplanung erörtert und Einsatzpotenziale aufgezeigt, die sich durch die verbesserte Hardware erschließen lassen.   Virtual and Augmented Reality Glasses have made significant progress. This paper shows the current state of technology as well as previous impediments in usage and points out applications for an efficient factory planning.

scholarly journals Host-pathogen coevolution and the emergence of broadly neutralizing antibodies in chronic infections

2015 ◽  
Author(s):  
Armita Nourmohammad ◽  
Jakub Otwinowski ◽  
Joshua B Plotkin
Keyword(s):  
Immune System ◽  
Neutralizing Antibodies ◽  
Adaptive Immune System ◽  
Analytical Framework ◽  
Mathematical Framework ◽  
Broadly Neutralizing Antibodies ◽  
Chronic Infections ◽  
Adaptive Immune ◽  
Immune Parameters ◽  
Genotype Frequencies

The vertebrate adaptive immune system provides a flexible and diverse set of molecules to neutralize pathogens. Yet, viruses such as HIV can cause chronic infections by evolving as quickly as the adaptive immune system, forming an evolutionary arms race. Here we introduce a mathematical framework to study the coevolutionary dynamics of antibodies with antigens within a host. We focus on changes in the binding interactions between the antibody and antigen populations, which result from the underlying stochastic evolution of genotype frequencies driven by mutation, selection, and drift. We identify the critical viral and immune parameters that determine the distribution of antibody-antigen binding affinities. We also identify definitive signatures of coevolution that measure the reciprocal response between antibodies and viruses, and we introduce experimentally measurable quantities that quantify the extent of adaptation during continual coevolution of the two opposing populations. Using this analytical framework, we infer rates of viral and immune adaptation based on time-shifted neutralization assays in two HIV-infected patients. Finally, we analyze competition between clonal lineages of antibodies and characterize the fate of a given lineage in terms of the state of the antibody and viral populations. In particular, we derive the conditions that favor the emergence of broadly neutralizing antibodies, which may be useful in designing a vaccine against HIV.

scholarly journals Multimodal Emotion Recognition using Deep Learning

2021 ◽  
Vol 2 (02) ◽  
pp. 52-58
Author(s):  
Sharmeen M.Saleem Abdullah Abdullah ◽  
Siddeeq Y. Ameen Ameen ◽  
Mohammed Mohammed sadeeq ◽  
Subhi Zeebaree
Keyword(s):  
Deep Learning ◽  
Affective Computing ◽  
Emotional Awareness ◽  
Computing Systems ◽  
Multimodal Signals ◽  
Current State ◽  
Multimodal Emotion Recognition ◽  
New Research ◽  
State Of The Science ◽  
Facial Images

New research into human-computer interaction seeks to consider the consumer's emotional status to provide a seamless human-computer interface. This would make it possible for people to survive and be used in widespread fields, including education and medicine. Multiple techniques can be defined through human feelings, including expressions, facial images, physiological signs, and neuroimaging strategies. This paper presents a review of emotional recognition of multimodal signals using deep learning and comparing their applications based on current studies. Multimodal affective computing systems are studied alongside unimodal solutions as they offer higher accuracy of classification. Accuracy varies according to the number of emotions observed, features extracted, classification system and database consistency. Numerous theories on the methodology of emotional detection and recent emotional science address the following topics. This would encourage studies to understand better physiological signals of the current state of the science and its emotional awareness problems.

E-Government Development in Serbia

2013 ◽  
pp. 265-290
Author(s):  
Sanja Bogdanovic-Dinic ◽  
Nataša Veljkovic ◽  
Leonid Stoimenov
Keyword(s):  
Developing Countries ◽  
Developing Nations ◽  
Considerable Importance ◽  
Significant Progress ◽  
Staff Education ◽  
Current State ◽  
History Of ◽  
Ict Infrastructure ◽  
Laws And Policies ◽  
Government Development

Attaining highly efficient e-Government in developing countries is a true challenge. These countries are struggling with many internal issues that are preventing them from providing budgetary resources for investing in ICT infrastructure, staff education, developing strategies, and enacting laws and policies. However, realizing the benefits that e-Government can bring, both to citizens and administration, these countries are working hard towards implementing e-Government and are achieving great results. As one of the developing countries, Serbia has been struggling for years with e-Government ideas. It started with humble implementations nearly ten years ago by publishing only a few informational services, but quickly made significant progress. The efforts made are worthy of recognition while experience gained is of considerable importance not only for Serbia’s further advances in this area but also for all other developing countries as an example and guidance to solving similar problems. This chapter provides an overview of the current state and history of e-Government development in Serbia and presents important issues and challenges influencing Serbian adoption of e-Government, which can be recognized in other developing countries as well. The chapter also addresses other issues and challenges that are now facing developed Governments, but which are on the way to developing nations as well. Even though these countries are not currently setting their focus on them, they should not be ignored nor neglected—indeed these should be included in developmental plans and strategies in order to successfully overcome them when the time comes.

scholarly journals ALS drug development guidances and trial guidelines

Neurology ◽  
2019 ◽  
Vol 93 (2) ◽  
pp. 66-71 ◽  
Author(s):  
Jinsy A. Andrews ◽  
Lucie I. Bruijn ◽  
Jeremy M. Shefner
Keyword(s):  
Drug Development ◽  
External Input ◽  
Draft Guidance ◽  
Current State ◽  
Community Stakeholders ◽  
Predictive Algorithms ◽  
Wide Range ◽  
The Us ◽  
New Treatments ◽  
State Of The Science

The US Food and Drug Administration (FDA) developed a draft guidance for drug development in amyotrophic lateral sclerosis (ALS) that was issued in February 2018. The FDA draft guidance considered the recommendations developed by the ALS community that incorporated the views of a large group of clinical investigators, industry representatives, advocacy groups, patients, and caregivers. This external input from the ALS community reviewed the current state of clinical research in ALS, made suggestions over a wide range of drug development topics, and served as an educational tool to provide the agency with additional inputs about ALS, the state of the science, and the community's views on key topics. In parallel to this effort, there was an independent effort to revise and update the ALS Clinical Trial Guidelines. We discuss the areas of agreement of these 3 documents and the areas that provide opportunities to improve the efficiency of drug development in ALS. It is likely that further research into biomarkers, efficacy endpoints, and predictive algorithms will provide greater alignment among community stakeholders and increase clarity on drug development efforts going forward. Continued patient engagement and inclusion of patient experience data in every aspect of the drug development process will further facilitate the approval of new treatments.

Sign in / Sign up

Export Citation Format

Share Document