An updated patent review on drugs for the treatment of tuberculosis (2018-present)

: Tanshinones are a class of bioactive compounds present in the Chinese herbal medicine Danshen (Salvia miltiorrhiza Bunge), containing among others, abietane diterpene quinone scaffolds. Chemical synthesis and biological activity studies of natural and unnatural tanshinone derivatives have been reviewed in this article.

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MDM2-p53 Interaction Inhibitors: The Current State-of-Art and Updated Patent Review (2010-Present)

Recent Patents on Anti-Cancer Drug Discovery ◽

10.2174/1574892814666191022163540 ◽

2020 ◽

Vol 14 (4) ◽

pp. 324-369 ◽

Cited By ~ 2

Author(s):

Rafał Rusiecki ◽

Jakub Witkowski ◽

Joanna Jaszczewska-Adamczak

Keyword(s):

Therapeutic Potential ◽

Research Work ◽

Academic Research ◽

Tumor Suppressor P53 ◽

Research Groups ◽

Current State ◽

Mouse Double Minute ◽

Patent Review ◽

Main Emphasis ◽

Double Minute

Background: Mouse Double Minute 2 protein (MDM2) is a cellular regulator of p53 tumor suppressor (p53). Inhibition of the interaction between MDM2 and p53 proteins is a promising anticancer therapy. Objective: This updated patent review is an attempt to compile the research and achievements of the various researchers working on small molecule MDM2 inhibitors from 2010 to date. We provide an outlook into the future for therapy based on MDM2 inhibition by presenting an overview of the most relevant patents which have recently appeared in the literature. Methods: Literature and recent patents focusing on the anticancer potential of MDM2-p53 interaction inhibitors and its applications have been analyzed. We put the main emphasis on the most perspective compounds which are or were examined in clinical trials. Results: Literature data indicated that MDM2 inhibitors are therapeutically effective in specific types of cancer or non-cancer diseases. A great number of patents and research work around new MDM2- p53 interaction inhibitors, possible combinations, new indications, clinical regimens in previous years prove that this targeted therapy is in the scope of interest for many business and academic research groups. Conclusion: Novel MDM2 inhibitors thanks to higher potency and better ADME properties have shown effectiveness in preclinical and clinical development however the final improvement of therapeutic potential for MDM2 inhibitors might depend on the useful combination therapy and exploring new cancer and non-cancer indications.

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BET Inhibitors as Anticancer Agents: A Patent Review

Recent Patents on Anti-Cancer Drug Discovery ◽

10.2174/1574892812666170808121228 ◽

2017 ◽

Vol 12 (4) ◽

Cited By ~ 10

Author(s):

Imran Ali ◽

Gildon Choi ◽

Kwangho Lee

Keyword(s):

Anticancer Agents ◽

Patent Review ◽

Bet Inhibitors

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Medicinal Chemistry Insights into Novel HDAC Inhibitors: An Updated Patent Review (2012-2016)

Recent Patents on Anti-Cancer Drug Discovery ◽

10.2174/1574892811666161101102842 ◽

2017 ◽

Vol 12 (1) ◽

pp. 16-34 ◽

Cited By ~ 15

Author(s):

Peng Zhan ◽

Xueshun Wang ◽

Xinyong Liu ◽

Takayoshi Suzuki

Keyword(s):

Medicinal Chemistry ◽

Hdac Inhibitors ◽

Patent Review

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Oral Solid Self-Emulsifying Formulations: A Patent Review

Recent Patents on Drug Delivery & Formulation ◽

10.2174/1872211308666140313145836 ◽

2014 ◽

Vol 8 (2) ◽

pp. 126-143 ◽

Cited By ~ 15

Author(s):

Bapurao Tarate ◽

Rahul Chavan ◽

Arvind Bansal

Keyword(s):

Patent Review

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Taking Cell Culture in Drug Discovery to the Third Dimension - A Patent Review

Recent Patents on Biomedical Engineering ◽

10.2174/1874764710801020103 ◽

2008 ◽

Vol 1 (2) ◽

pp. 103-115

Author(s):

Yinzhi Lai ◽

Lina Wang ◽

Ke Cheng ◽

William Kisaalita

Keyword(s):

Cell Culture ◽

Drug Discovery ◽

The Third ◽

Patent Review ◽

Third Dimension

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A Review of Recent Patents (2016-2019) on Plant Food Supplements with Potential Application in the Treatment of Neurodegenerative and Metabolic Disorders

Recent Patents on Food Nutrition & Agriculturee ◽

10.2174/2212798411666200313145824 ◽

2020 ◽

Vol 11 (2) ◽

pp. 145-153 ◽

Cited By ~ 1

Author(s):

Rosalba Leuci ◽

Leonardo Brunetti ◽

Antonio Laghezza ◽

Paolo Tortorella ◽

Fulvio Loiodice ◽

...

Keyword(s):

Metabolic Disorders ◽

Food Supplements ◽

Plant Food ◽

Fortified Foods ◽

Patent Review ◽

Novel Strategy ◽

Lifestyle Related Diseases ◽

Near Future ◽

Prevention And Therapy

In the near future, it is expected that the prevalence of illnesses related to the increasing life expectancies and quality of life, such as neurodegenerative diseases and cardiovascular diseases related to metabolic disorders, will soar to unprecedented levels, leading to high socioeconomic costs. To address this rising threat, natural products are emerging as a novel strategy for the prevention and therapy of these ages- and lifestyle-related diseases, thanks to their high marketability and few side effects. In this patent review, we summarize selected patents for food supplements, functional and fortified foods, filed from 2016 to 2019, categorizing them based on the biological activity of their components.

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