Interaction of erythrocyte eicosapentaenoic acid and physical activity predicts reduced risk of mild cognitive impairment

Abstract Background Physical activity has been suggested to prevent the conversion of mild cognitive impairment (MCI) to dementia in patients. We investigated the association between the continuance and regularity of physical activity and the risk of developing dementia in patients with MCI. Methods We analyzed data for 247,149 individuals in the National Health Insurance Service (NHIS) cohort who were enrolled between January 1, 2009 and December 31, 2015. The patients were divided into four groups: those who did not engage in physical activity consistently (Never-PA group), those who initiated physical activity (Initiation-PA group), those who ceased physical activity (Withdrawal-PA group), and those who performed physical activity consistently (Maintenance-PA group). We also divided the patients into two groups: those who engaged in physical activity irregularly (Irregular-PA) and those who undertook physical activity regularly (Regular-PA). Results When the risk for the Never-PA group was set as the benchmark (ref=1), the Maintenance-PA group had the lowest incidence of Alzheimer’s disease (AD) compared to the other groups (HR= 0.82, 95% CI 0.79-0.86). The AD risk of Initiation-PA group (HR = 0.89, 95% CI 0.85-0.93) and Withdrawal-PA group (HR = 1, 95% CI 0.96-1.04) was still lower than the Never-PA group. In addition, compared to the Irregular-PA group, the Regular-PA group had a 15% reduced risk for developing AD. Conclusions Continued regular physical activity in patients with MCI is associated with a protective effect against developing AD. Moreover, ceasing physical activity could halt this protective effect.

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Association between physical activity and conversion from mild cognitive impairment to dementia

10.21203/rs.2.23855/v4 ◽

2020 ◽

Author(s):

Yeo Jin Kim ◽

Kyung-Do Han ◽

Min Seok Baek ◽

Hanna Cho ◽

Eun Joo Lee ◽

...

Keyword(s):

Physical Activity ◽

Cognitive Impairment ◽

Health Insurance ◽

Mild Cognitive Impairment ◽

Protective Effect ◽

National Health Insurance ◽

National Health ◽

The Other ◽

Alzheimer Type ◽

Reduced Risk

Abstract Background: Physical activity has been suggested to prevent the conversion of mild cognitive impairment (MCI) to dementia in patients. We investigated the association between the continuance and regularity of physical activity and the risk of developing dementia in patients with MCI.Methods: We analyzed 6-year followed up data for 247,149 individuals in the National Health Insurance Service (NHIS) cohort of Korea who were enrolled between January 1, 2009 and December 31, 2015. The patients were divided into four groups: those who did not engage in physical activity consistently (Never-PA group), those who initiated physical activity (Initiation-PA group), those who ceased physical activity (Withdrawal-PA group), and those who performed physical activity consistently (Maintenance-PA group). We also divided the patients into two groups: those who engaged in physical activity irregularly (Irregular-PA) and those who undertook physical activity regularly (Regular-PA).Results: When the risk for the Never-PA group was set as the benchmark (ref=1), the Maintenance-PA group had the lowest incidence of dementia of the Alzheimer type (DAT) compared to the other groups (HR= 0.82, 95% CI 0.79-0.86). The DAT risk of Initiation-PA group (HR = 0.89, 95% CI 0.85-0.93) was lower than the Never-PA group. In addition, compared to the Irregular-PA group, the Regular-PA group had a 15% reduced risk for developing DAT.Conclusions: Although no causal inference could be made, continued regular physical activity in patients with MCI is associated with a protective effect against developing DAT. Moreover, ceasing physical activity could halt this protective effect.

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Association between physical activity and conversion from mild cognitive impairment to dementia

10.21203/rs.2.23855/v2 ◽

2020 ◽

Author(s):

Yeo Jin Kim ◽

Kyung-Do Han ◽

Min Seok Baek ◽

Hanna Cho ◽

Eun Joo Lee ◽

...

Keyword(s):

Physical Activity ◽

Cognitive Impairment ◽

Health Insurance ◽

Mild Cognitive Impairment ◽

Protective Effect ◽

National Health Insurance ◽

National Health ◽

The Other ◽

Alzheimer Type ◽

Reduced Risk

Abstract Background: Physical activity has been suggested to prevent the conversion of mild cognitive impairment (MCI) to dementia in patients. We investigated the association between the continuance and regularity of physical activity and the risk of developing dementia in patients with MCI.Methods: We analyzed 6-year followed up data for 247,149 individuals in the National Health Insurance Service (NHIS) cohort of Korea who were enrolled between January 1, 2009 and December 31, 2015. The patients were divided into four groups: those who did not engage in physical activity consistently (Never-PA group), those who initiated physical activity (Initiation-PA group), those who ceased physical activity (Withdrawal-PA group), and those who performed physical activity consistently (Maintenance-PA group). We also divided the patients into two groups: those who engaged in physical activity irregularly (Irregular-PA) and those who undertook physical activity regularly (Regular-PA).Results: When the risk for the Never-PA group was set as the benchmark (ref=1), the Maintenance-PA group had the lowest incidence of dementia of the Alzheimer type (DAT) compared to the other groups (HR= 0.82, 95% CI 0.79-0.86). The DAT risk of Initiation-PA group (HR = 0.89, 95% CI 0.85-0.93) was lower than the Never-PA group. In addition, compared to the Irregular-PA group, the Regular-PA group had a 15% reduced risk for developing DAT.Conclusions: Continued regular physical activity in patients with MCI is associated with a protective effect against developing DAT. Moreover, ceasing physical activity could halt this protective effect.

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Association between physical activity and conversion from mild cognitive impairment to dementia

Alzheimer s Research & Therapy ◽

10.1186/s13195-020-00707-1 ◽

2020 ◽

Vol 12 (1) ◽

Author(s):

Yeo Jin Kim ◽

Kyung-Do Han ◽

Min Seok Baek ◽

Hanna Cho ◽

Eun Joo Lee ◽

...

Keyword(s):

Physical Activity ◽

Cognitive Impairment ◽

Health Insurance ◽

Mild Cognitive Impairment ◽

Protective Effect ◽

National Health Insurance ◽

National Health ◽

The Other ◽

Alzheimer Type ◽

Reduced Risk

Abstract Background Physical activity has been suggested to prevent the conversion of mild cognitive impairment (MCI) to dementia in patients. We investigated the association between the continuance and regularity of physical activity and the risk of developing dementia in patients with MCI. Methods We analyzed 6-year followed up data for 247,149 individuals in the National Health Insurance Service (NHIS) cohort of Korea who were enrolled between January 1, 2009, and December 31, 2015. The patients were divided into four groups: those who did not engage in physical activity consistently (Never-PA group), those who initiated physical activity (Initiation-PA group), those who ceased physical activity (Withdrawal-PA group), and those who performed physical activity consistently (Maintenance-PA group). We also divided the patients into two groups: those who engaged in physical activity irregularly (Irregular-PA) and those who undertook physical activity regularly (Regular-PA). Results When the risk for the Never-PA group was set as the benchmark (ref = 1), the Maintenance-PA group had the lowest incidence of dementia of the Alzheimer type (DAT) compared to the other groups (HR = 0.82, 95% CI 0.79–0.86). The DAT risk of the Initiation-PA group (HR = 0.89, 95% CI 0.85–0.93) was lower than the Never-PA group. In addition, compared to the Irregular-PA group, the Regular-PA group had a 15% reduced risk for developing DAT. Conclusions Although no causal inference could be made, continued regular physical activity in patients with MCI is associated with a protective effect against developing DAT. Moreover, ceasing physical activity could halt this protective effect.

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Association between physical activity and conversion from mild cognitive impairment to dementia

10.21203/rs.2.23855/v3 ◽

2020 ◽

Author(s):

Yeo Jin Kim ◽

Kyung-Do Han ◽

Min Seok Baek ◽

Hanna Cho ◽

Eun Joo Lee ◽

...

Keyword(s):

Physical Activity ◽

Cognitive Impairment ◽

Health Insurance ◽

Mild Cognitive Impairment ◽

Protective Effect ◽

National Health Insurance ◽

National Health ◽

The Other ◽

Alzheimer Type ◽

Reduced Risk

Abstract Background Physical activity has been suggested to prevent the conversion of mild cognitive impairment (MCI) to dementia in patients. We investigated the association between the continuance and regularity of physical activity and the risk of developing dementia in patients with MCI. Methods We analyzed 6-year followed up data for 247,149 individuals in the National Health Insurance Service (NHIS) cohort of Korea who were enrolled between January 1, 2009 and December 31, 2015. The patients were divided into four groups: those who did not engage in physical activity consistently (Never-PA group), those who initiated physical activity (Initiation-PA group), those who ceased physical activity (Withdrawal-PA group), and those who performed physical activity consistently (Maintenance-PA group). We also divided the patients into two groups: those who engaged in physical activity irregularly (Irregular-PA) and those who undertook physical activity regularly (Regular-PA). Results When the risk for the Never-PA group was set as the benchmark (ref=1), the Maintenance-PA group had the lowest incidence of dementia of the Alzheimer type (DAT) compared to the other groups (HR= 0.82, 95% CI 0.79-0.86 ). The DAT risk of Initiation-PA group (HR = 0.89, 95% CI 0.85-0.93 ) was lower than the Never-PA group. In addition, compared to the Irregular-PA group, the Regular-PA group had a 15% reduced risk for developing DAT. Conclusions Although no causal inference could be made, continued regular physical activity in patients with MCI is associated with a protective effect against developing DAT. Moreover, ceasing physical activity could halt this protective effect.

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Integrating Mind Body Skills and Physical Activity in Older Adults With Mild Cognitive Impairment (MCI) and Chronic Pain

Case Medical Research ◽

10.31525/ct1-nct04044183 ◽

2019 ◽

Author(s):

Keyword(s):

Physical Activity ◽

Older Adults ◽

Chronic Pain ◽

Cognitive Impairment ◽

Mild Cognitive Impairment

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Multi-Component Intervention Program on Habitual Physical Activity Parameters and Cognitive Function in Patients with Mild Cognitive Impairment: A Randomized Controlled Trial

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18126240 ◽

2021 ◽

Vol 18 (12) ◽

pp. 6240

Author(s):

Min-Ki Jeong ◽

Kyung-Won Park ◽

Je-Kwang Ryu ◽

Gwon-Min Kim ◽

Hyun-Hun Jung ◽

...

Keyword(s):

Physical Activity ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Cognitive Function ◽

Intervention Program ◽

Vigorous Physical Activity ◽

Cognitive Intervention ◽

Habitual Physical Activity ◽

Disease Assessment ◽

Digit Symbol Substitution Test

Age-related dementia refers to a state in which someone experiences multiple cognitive function impairment due to degenerative brain disease, and which causes difficulties in their daily life or social life. Dementia is the most common and serious obstacle in later life. Early intervention in the case of patients who are in the mild cognitive impairment (MCI) stage among the high-risk group can maintain and improve their cognitive function. The purpose of the current trial is aimed at investigating the association between a multi-component (exercise with cognitive) intervention program and habitual physical activity parameters on cognitive functions in MCI patients. Neuropsychological cognitive and depression assessments were performed by neuropsychologists according to normalized methods, including the Korean mini-mental State examination (K-MMSE) and modified Alzheimer’s disease assessment scale-cognitive subscale (ADAS-Cog) and cognitive assessment tool (attention, processing speed), and the Korean version of the geriatric depression scale (SGDS-K), both at baseline and at a 12 weeks follow-up. The 12-week multi-component intervention improved cognitive function and habitual physical activity parameters in patients with MCI relative to controls. A multi-component intervention program for patients with MCI is considered to be an effective method of dementia prevention by improving global (ADAS-Cog) and frontal (trail-making test, digit symbol substitution test) cognition and habitual physical activity parameters such as moderate to vigorous physical activity and step count. In addition, it is important to encourage habitual physical activities to ensure that exercise intervention strategies are carried out at the duration and intensity required for improving physical and cognitive wellbeing and obtaining health benefits.

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