Association between physical activity and conversion from mild cognitive impairment to dementia

Abstract Background Physical activity has been suggested to prevent the conversion of mild cognitive impairment (MCI) to dementia in patients. We investigated the association between the continuance and regularity of physical activity and the risk of developing dementia in patients with MCI. Methods We analyzed data for 247,149 individuals in the National Health Insurance Service (NHIS) cohort who were enrolled between January 1, 2009 and December 31, 2015. The patients were divided into four groups: those who did not engage in physical activity consistently (Never-PA group), those who initiated physical activity (Initiation-PA group), those who ceased physical activity (Withdrawal-PA group), and those who performed physical activity consistently (Maintenance-PA group). We also divided the patients into two groups: those who engaged in physical activity irregularly (Irregular-PA) and those who undertook physical activity regularly (Regular-PA). Results When the risk for the Never-PA group was set as the benchmark (ref=1), the Maintenance-PA group had the lowest incidence of Alzheimer’s disease (AD) compared to the other groups (HR= 0.82, 95% CI 0.79-0.86). The AD risk of Initiation-PA group (HR = 0.89, 95% CI 0.85-0.93) and Withdrawal-PA group (HR = 1, 95% CI 0.96-1.04) was still lower than the Never-PA group. In addition, compared to the Irregular-PA group, the Regular-PA group had a 15% reduced risk for developing AD. Conclusions Continued regular physical activity in patients with MCI is associated with a protective effect against developing AD. Moreover, ceasing physical activity could halt this protective effect.

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Association between physical activity and conversion from mild cognitive impairment to dementia

10.21203/rs.2.23855/v4 ◽

2020 ◽

Author(s):

Yeo Jin Kim ◽

Kyung-Do Han ◽

Min Seok Baek ◽

Hanna Cho ◽

Eun Joo Lee ◽

...

Keyword(s):

Physical Activity ◽

Cognitive Impairment ◽

Health Insurance ◽

Mild Cognitive Impairment ◽

Protective Effect ◽

National Health Insurance ◽

National Health ◽

The Other ◽

Alzheimer Type ◽

Reduced Risk

Abstract Background: Physical activity has been suggested to prevent the conversion of mild cognitive impairment (MCI) to dementia in patients. We investigated the association between the continuance and regularity of physical activity and the risk of developing dementia in patients with MCI.Methods: We analyzed 6-year followed up data for 247,149 individuals in the National Health Insurance Service (NHIS) cohort of Korea who were enrolled between January 1, 2009 and December 31, 2015. The patients were divided into four groups: those who did not engage in physical activity consistently (Never-PA group), those who initiated physical activity (Initiation-PA group), those who ceased physical activity (Withdrawal-PA group), and those who performed physical activity consistently (Maintenance-PA group). We also divided the patients into two groups: those who engaged in physical activity irregularly (Irregular-PA) and those who undertook physical activity regularly (Regular-PA).Results: When the risk for the Never-PA group was set as the benchmark (ref=1), the Maintenance-PA group had the lowest incidence of dementia of the Alzheimer type (DAT) compared to the other groups (HR= 0.82, 95% CI 0.79-0.86). The DAT risk of Initiation-PA group (HR = 0.89, 95% CI 0.85-0.93) was lower than the Never-PA group. In addition, compared to the Irregular-PA group, the Regular-PA group had a 15% reduced risk for developing DAT.Conclusions: Although no causal inference could be made, continued regular physical activity in patients with MCI is associated with a protective effect against developing DAT. Moreover, ceasing physical activity could halt this protective effect.

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Association between physical activity and conversion from mild cognitive impairment to dementia

10.21203/rs.2.23855/v2 ◽

2020 ◽

Author(s):

Yeo Jin Kim ◽

Kyung-Do Han ◽

Min Seok Baek ◽

Hanna Cho ◽

Eun Joo Lee ◽

...

Keyword(s):

Physical Activity ◽

Cognitive Impairment ◽

Health Insurance ◽

Mild Cognitive Impairment ◽

Protective Effect ◽

National Health Insurance ◽

National Health ◽

The Other ◽

Alzheimer Type ◽

Reduced Risk

Abstract Background: Physical activity has been suggested to prevent the conversion of mild cognitive impairment (MCI) to dementia in patients. We investigated the association between the continuance and regularity of physical activity and the risk of developing dementia in patients with MCI.Methods: We analyzed 6-year followed up data for 247,149 individuals in the National Health Insurance Service (NHIS) cohort of Korea who were enrolled between January 1, 2009 and December 31, 2015. The patients were divided into four groups: those who did not engage in physical activity consistently (Never-PA group), those who initiated physical activity (Initiation-PA group), those who ceased physical activity (Withdrawal-PA group), and those who performed physical activity consistently (Maintenance-PA group). We also divided the patients into two groups: those who engaged in physical activity irregularly (Irregular-PA) and those who undertook physical activity regularly (Regular-PA).Results: When the risk for the Never-PA group was set as the benchmark (ref=1), the Maintenance-PA group had the lowest incidence of dementia of the Alzheimer type (DAT) compared to the other groups (HR= 0.82, 95% CI 0.79-0.86). The DAT risk of Initiation-PA group (HR = 0.89, 95% CI 0.85-0.93) was lower than the Never-PA group. In addition, compared to the Irregular-PA group, the Regular-PA group had a 15% reduced risk for developing DAT.Conclusions: Continued regular physical activity in patients with MCI is associated with a protective effect against developing DAT. Moreover, ceasing physical activity could halt this protective effect.

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Association between physical activity and conversion from mild cognitive impairment to dementia

Alzheimer s Research & Therapy ◽

10.1186/s13195-020-00707-1 ◽

2020 ◽

Vol 12 (1) ◽

Author(s):

Yeo Jin Kim ◽

Kyung-Do Han ◽

Min Seok Baek ◽

Hanna Cho ◽

Eun Joo Lee ◽

...

Keyword(s):

Physical Activity ◽

Cognitive Impairment ◽

Health Insurance ◽

Mild Cognitive Impairment ◽

Protective Effect ◽

National Health Insurance ◽

National Health ◽

The Other ◽

Alzheimer Type ◽

Reduced Risk

Abstract Background Physical activity has been suggested to prevent the conversion of mild cognitive impairment (MCI) to dementia in patients. We investigated the association between the continuance and regularity of physical activity and the risk of developing dementia in patients with MCI. Methods We analyzed 6-year followed up data for 247,149 individuals in the National Health Insurance Service (NHIS) cohort of Korea who were enrolled between January 1, 2009, and December 31, 2015. The patients were divided into four groups: those who did not engage in physical activity consistently (Never-PA group), those who initiated physical activity (Initiation-PA group), those who ceased physical activity (Withdrawal-PA group), and those who performed physical activity consistently (Maintenance-PA group). We also divided the patients into two groups: those who engaged in physical activity irregularly (Irregular-PA) and those who undertook physical activity regularly (Regular-PA). Results When the risk for the Never-PA group was set as the benchmark (ref = 1), the Maintenance-PA group had the lowest incidence of dementia of the Alzheimer type (DAT) compared to the other groups (HR = 0.82, 95% CI 0.79–0.86). The DAT risk of the Initiation-PA group (HR = 0.89, 95% CI 0.85–0.93) was lower than the Never-PA group. In addition, compared to the Irregular-PA group, the Regular-PA group had a 15% reduced risk for developing DAT. Conclusions Although no causal inference could be made, continued regular physical activity in patients with MCI is associated with a protective effect against developing DAT. Moreover, ceasing physical activity could halt this protective effect.

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Association between physical activity and conversion from mild cognitive impairment to dementia

10.21203/rs.2.23855/v3 ◽

2020 ◽

Author(s):

Yeo Jin Kim ◽

Kyung-Do Han ◽

Min Seok Baek ◽

Hanna Cho ◽

Eun Joo Lee ◽

...

Keyword(s):

Physical Activity ◽

Cognitive Impairment ◽

Health Insurance ◽

Mild Cognitive Impairment ◽

Protective Effect ◽

National Health Insurance ◽

National Health ◽

The Other ◽

Alzheimer Type ◽

Reduced Risk

Abstract Background Physical activity has been suggested to prevent the conversion of mild cognitive impairment (MCI) to dementia in patients. We investigated the association between the continuance and regularity of physical activity and the risk of developing dementia in patients with MCI. Methods We analyzed 6-year followed up data for 247,149 individuals in the National Health Insurance Service (NHIS) cohort of Korea who were enrolled between January 1, 2009 and December 31, 2015. The patients were divided into four groups: those who did not engage in physical activity consistently (Never-PA group), those who initiated physical activity (Initiation-PA group), those who ceased physical activity (Withdrawal-PA group), and those who performed physical activity consistently (Maintenance-PA group). We also divided the patients into two groups: those who engaged in physical activity irregularly (Irregular-PA) and those who undertook physical activity regularly (Regular-PA). Results When the risk for the Never-PA group was set as the benchmark (ref=1), the Maintenance-PA group had the lowest incidence of dementia of the Alzheimer type (DAT) compared to the other groups (HR= 0.82, 95% CI 0.79-0.86 ). The DAT risk of Initiation-PA group (HR = 0.89, 95% CI 0.85-0.93 ) was lower than the Never-PA group. In addition, compared to the Irregular-PA group, the Regular-PA group had a 15% reduced risk for developing DAT. Conclusions Although no causal inference could be made, continued regular physical activity in patients with MCI is associated with a protective effect against developing DAT. Moreover, ceasing physical activity could halt this protective effect.

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Interaction of erythrocyte eicosapentaenoic acid and physical activity predicts reduced risk of mild cognitive impairment

Aging & Mental Health ◽

10.1080/13607863.2014.971705 ◽

2014 ◽

Vol 19 (10) ◽

pp. 885-891 ◽

Cited By ~ 7

Author(s):

Steven John Street ◽

Natalie Parletta ◽

Catherine Milte ◽

Karen Sullivan ◽

Andrew P. Hills ◽

...

Keyword(s):

Physical Activity ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Eicosapentaenoic Acid ◽

Reduced Risk

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P772 Trends and risk factors of elderly-onset Crohn’s disease: A nationwide cohort study in South Korea

Journal of Crohn s and Colitis ◽

10.1093/ecco-jcc/jjz203.900 ◽

2020 ◽

Vol 14 (Supplement_1) ◽

pp. S612-S613

Author(s):

J M Moon ◽

E A Kang ◽

K Han ◽

S W Hong ◽

H Soh ◽

...

Keyword(s):

Physical Activity ◽

Risk Factors ◽

Health Insurance ◽

Alcohol Consumption ◽

National Health Insurance ◽

National Health ◽

Age Groups ◽

Middle Aged ◽

Aged Group

Abstract Background The incidence of inflammatory bowel disease (IBD) is increasing in Asia. Numerous risk factors associated with IBD development have been investigated. This study aimed to demonstrate the risk factors of Crohn’s disease (CD) diagnosed in persons aged >40 years in South Korea and to specify any differences between age groups by using the National Health Insurance Service (NHIS) database. Methods Using the National Health Insurance Service (NHIS) database, a total of 14,060,821 persons aged >40 years who underwent national health screening in 2009 were followed up until December 2017. Patients with newly diagnosed CD were enrolled and compared with non-CD cohort. CD was identified according to the International Classification of Diseases 10th revision and the rare/intractable disease registration programme codes from the NHIS database. The mean follow-up periods were 7.39 years. Age and sex were adjusted for in the multivariate analysis model. Results During the follow-up, 1337 (1.33/100,000) patients developed CD. Men in the middle-aged group (40–64 years) had a higher risk than women (adjusted HR [aHR] 1.46, 95% CI 1.29–1.66); however, this difference tended to disappear as the age of onset increases. In the middle-aged group, patients with a history of smoking (adjusted hazard ratio [aHR] 1.29, 95% confidence interval [CI] 1.06–1.58) and anemia (aHR 1.99, 95% CI 1.67–2.36) had a significantly higher CD risk. In the elderly group (age, ³65 years), ex-smoking and anemia also increased the CD risk (aHR 1.58 [95% CI 1.16–2.18] and 1.91 [95% CI 1.53–2.38], respectively). Especially in the middle-aged group, those with chronic kidney disease (CKD) had a statistically elevated CD risk (aHR 1.38, 95% CI 1.06–1.79). Alcohol consumption and higher body mass index showed negative association trend with CD incidence in both of the age groups. (Middle-aged: aHR 0.76 [95%CI 0.65–0.87] and aHR 0.38 [95%CI 0.27–0.53], respectively) (elderly-group: aHR 0.57 [95%CI 0.42–0.77] and aHR 0.52 [95%CI 0.32-.83], respectively) For regular physical activity and dyslipidemia, negative correlation between CD incidences was proved only in the middle-aged group (aHR 0.85 [95%CI 0.74–0.96] and aHR 0. [95%CI 0.75 [95% CI 0.63–0.89], respectively). Conclusion This study demonstrated four risk factors (ex-smoking, anemia, CKD, and lower BMI) and three possible protective factors (alcohol consumption, physical activity, and dyslipidemia) for CD in Asians age >40 years. Individuals with potential risk factors need more cautious monitoring for CD.

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Physical Activity as a “Cheapest Health Tax Payment” Toward Better Health for All

Review of Primary Care Practice and Education (Kajian Praktik dan Pendidikan Layanan Primer) ◽

10.22146/rpcpe.46014 ◽

2019 ◽

Vol 2 (2) ◽

pp. 52

Author(s):

Ernawati Ernawati

Keyword(s):

Physical Activity ◽

Health Insurance ◽

National Health Insurance ◽

National Health ◽

Health Financing ◽

Non Communicable Diseases ◽

Health Related ◽

Prevention Activities ◽

Actual Health ◽

Over Time

Indonesia currently faces many health-related problems, both in terms of increased morbidity and mortality due to infectious and non-communicable diseases, which stem from increasing unhealthy behaviors. The progress of science and technology is still not able to overcome this dilemma. Another problem is that actual health financing is already very good for helping communities with the existence of National Health Insurance. But over time it turned out that many obstacles appeared that could disrupt its sustainability. This becomes a serious problem that must be well thought out for the community so that people are not harmed. All of these problems arise as a result of the majority of people who have not been actively involved in prevention activities. Most of our society has behaviors that do not support health, but they engage in inactivity that is actually detrimental to health.

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Association of gout with CAD and effect of antigout therapy on CVD risk among gout patients

Journal of Investigative Medicine ◽

10.1136/jim-2019-001140 ◽

2020 ◽

Vol 68 (5) ◽

pp. 972-979 ◽

Cited By ~ 1

Author(s):

Wei-Shih Huang ◽

Cheng-Li Lin ◽

Chon-Haw Tsai ◽

Kuang-Hsi Chang

Keyword(s):

Risk Factor ◽

Health Insurance ◽

National Health Insurance ◽

National Health ◽

Proportional Hazards ◽

Cox Proportional Hazards ◽

Research Database ◽

Sampled Data ◽

Cvd Risk ◽

Reduced Risk

Hyperuricemia has been identified as an independent risk factor for coronary artery disease (CAD), with a dose–response association. In this study, we explored the causal association between gout and antigout medication and the risk of incidental CAD. We sampled data from the National Health Insurance Research Database and recruited 37,091 patients as the gout cohort, and 37,091 controls. Our primary endpoint was the diagnosis of CAD during follow-up. The overall study population was followed up until CAD diagnosis, withdrawal from the National Health Insurance program, or the end of the study. Cox proportional hazards regression models were used to examine the effect of gout on the risk of CAD, represented by the HR with the 95% CI. Patients with gout were at greater risk of CAD, compared with those without gout: HR=1.49 after adjusting for potential confounders. Non-steroidal anti-inflammatory drugs and prednisolone use was associated with a reduced risk of CAD: HR=0.63 and 0.50, respectively. Patients with gout, treated with antigout medication, exhibited a reduced risk of CAD compared with non-gout patients. Among patients with gout, those on antigout therapy had 32% lower risk compared with those not on antigout therapy: adjusted HR=0.68, 95% CI 0.63 to 0.73. Gout increases the risk of CAD, and the use of antigout medication reduces CAD risk. These results indicate that gout or hyperuricemia is a modifiable risk factor for CAD.

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Factors Predicting afterward Childbirth for Infertile Women: The Intensity of Physical Activity

JOURNAL OF THE KOREAN SOCIETY OF MATERNAL AND CHILD HEALTH ◽

10.21896/jksmch.2021.25.3.197 ◽

2021 ◽

Vol 25 (3) ◽

pp. 197-203

Author(s):

Kyueun Han ◽

Min Young Km

Keyword(s):

Physical Activity ◽

Body Mass Index ◽

Health Insurance ◽

Linear Regression ◽

Body Mass ◽

National Health Insurance ◽

National Health ◽

Descriptive Statistics ◽

Infertile Women ◽

Intense Physical Activity

Purpose: The aim of this study was to investigate the intensity of physical activity predicting afterward childbirth for infertile women in order to improve the development of an infertility support.Methods: The complete enumeration data of the National Health Insurance Service of Korea for women who had been diagnosed with infertility in 2016 were analyzed to investigate the predictors of childbirth in 2016–2017. The data were analyzed using descriptive statistics and linear regression with SPSS.Results: When age and body mass index were controlled for, intermediate intense physical activity increased the rate of childbirth, but low or heavy intensity did not.Conclusion: Women who have been diagnosed with infertility should be given advice to engage in intermediate levels of physical activity in order to increase their chances of having a child.

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