This study presents the results of a nonlinear response-history (NLRH) investigation of cantilever and coupled wall systems, in which the contribution of higher modes to the dynamic response is significant. The limitations of the so-called reduced response spectrum analysis method to predict higher-mode inelastic response are identified and the reasons for its shortcomings are explained. Two procedures for the prediction of the inelastic response of higher modes are presented. The first method is based on the substitute structure method and requires only elastic modal analysis, making it particularly fit for traditional design purposes. The second method is based on structural dynamics closed-form solutions, and it does not require finite element method (FEM) analysis, making it particularly fit for simplified capacity design purposes. The approaches show very good agreement with the results of the NLRH investigation for any structural period, ductility demand, and coupling ratio. Future research should aim to further verify the new methods using more refined modeling and analysis approaches.