Workplace Mistreatment: A Review and Agenda for Research

Workplace mistreatment researchers study negative interpersonal behaviors under a plethora of different labels, including incivility, bullying, harassment, aggression, and violence. While negative interpersonal behaviors differ in their intensity, intent, and frequency, a common denominator of these behaviors is their adverse impact on employees and organizations. Research has identified the nomological network of workplace mistreatment, which illustrates individual and contextual factors associated with mistreatment behaviors. Authors have also highlighted outcomes of mistreatment, showing that mistreatment results in reduced psychological and physical health, worsened job attitudes, and diminished performance for both targets and bystanders. Further, enacted mistreatment is not without consequences for the perpetrators, and these consequences can be both negative and positive. While workplace mistreatment research has been steadily growing, many questions remain unanswered. There are unexplored topics, approaches, and methodologies. First, there is a need to understand the uniqueness and similarities of different mistreatment constructs to provide a more comprehensive approach for studying workplace mistreatment and highlight alternative ways of measuring mistreatment constructs. Novel methodological approaches, such as HotMap and artificial intelligence, could shed light on the dynamics between targets and perpetrators of mistreatment, allowing researchers to capture the dynamic nature of mistreatment behaviors. Second, the interactions among societal, cultural, and interpersonal factors are likely to shape enacted mistreatment. For instance, social networks within organizations and the interrelations between employees are likely to influence not only the individual who becomes targeted, but also the way in which bystanders are to take action against such mistreatment. Third, while the role of bystanders in the dynamics of workplace mistreatment is undoubtedly important, there is a need to critically investigate the role bystanders may play in curtailing or encouraging mistreatment. More specifically, bystander interventions can take both constructive and destructive forms. Finally, targets’ responses to experienced mistreatment are likely to be relevant to the understanding of the dyadic nature of workplace mistreatment, such that an aggressive target response is likely to cause a mistreatment spiraling. However, it remains unclear what type of target response, if any, would be beneficial in helping de-escalate destructive behavior from the perpetrator. Thus, more research is needed to help address the important question of the best ways to deal with experienced mistreatment.

On the uncertainty associated with detecting global and local mean sea level drifts on Sentinel-3A and Sentinel-3B altimetry missions

An instrumental drift in the Point Target Response (PTR) parameters has been detected on the Copernicus Sentinel-3A (S3A) altimetry mission. It could have an impact on sea level rise of a few tenths of mm yr−1. In order to accurately evaluate this drift, a method for detecting global and local mean sea level relative drifts between two altimetry missions is implemented. Associated uncertainties are also accurately calculated thanks to a detailed error budget analysis. A drift on both S3A and S3B GMSL is detected with values significantly higher than expected. For S3A, the relative GMSL drift detected is 1.0 mm yr−1 with Jason-3 and 1.3 mm yr−1 with SARAL/AltiKa. For S3B, the relative GMSL drift detected is −2.2 mm yr−1 with SARAL/AltiKa and −3.4 mm yr−1 with Jason-3. The drift detected at global level does not show detectable regional variations above the uncertainty level of the proposed method. The investigations led by the altimeter experts can now explain the origin of this drift for S3A, while it is still under investigation for S3B. The ability of the implemented method to detect a sea level drift with respect to the length of the common period is also analysed. We find that the maximum detectable sea-level drift over a 5 years period is 0.3 mm yr−1 at the global scale, and 1.5 mm yr−1 at local scales (2400 km). However, these levels of uncertainty do not meet the sea-level stability requirements for climate change studies.

Isatuximab Rescue for Inadequate Response to Lenalidomide and Dexamethasone in Transplant Ineligible Patients with Newly Diagnosed Multiple Myeloma: Interim Analysis of the Phase II Iril Study of the Australian Myeloma Research Consortium (AMaRC 18-02)

Background: Almost two thirds of transplant-ineligible, treatment naïve multiple myeloma (NDMM, TNE) patients (pts) do not proceed to second line anti-MM therapy. Given depth of response to initial therapy correlates to overall survival (OS), a deep remission should also be the target for this cohort of generally elderly and frail patients. However, this should not come at the expense of either treatment-related or fiscal toxicity. IRIL is a phase II, multicentre, response-adapted study examining treatment intensification with isatuximab (Isa; supported by Sanofi/Genzyme), an anti-CD38 monoclonal antibody, for pts not achieving pre-defined target responses to lenalidomide and dexamethasone (Rd). Method: TNE NDMM pts meeting IMWG criteria for treatment are eligible for enrolment. Pts commence treatment with lenalidomide [25mg D1-D21 of a 28-day cycle (C)] and dexamethasone [40mg (20mg for those aged ³75 years) PO weekly]. Failure to achieve pre-defined target response [<PR after 4 cycles, <VGPR after 6, or <CR after 9 cycles of Rd] or progressive disease (PD) within the first 9 cycles of Rd leads to addition of Isa (10mg/kg IV weekly for cycle 1, then fortnightly) until PD or adverse events (AEs) that warrant treatment cessation. The primary endpoint is to evaluate the rate of achievement of ³PR following completion of 6 cycles Isa-Rd in those who failed to achieve <PR after C4 Rd. The secondary endpoints are to evaluate overall improvement in depth of response to Isa-Rd, progression free survival (PFS), OS, and safety. Results: From June 2019 to June 2021, 42 pts [52.3% male, median age 77.7 yrs (range 68.5-86.0), R-ISS Stage I (n=8), Stage II (n=23) and Stage III (n=7)] were accrued. 30 pts have completed at least C4 Rd and were deemed evaluable (12 non-evaluable; 5 only recently recruited, 5 withdrew consent (WD) due to logistic reasons, 2 PD pre-C4 and were taken of study at investigator discretion). Of the 30 evaluable pts (see Figure 1), 25 remain on study with 2 further WD (logistic reasons) and 3 deaths. In total, 25pts have had treatment intensification with Isa [9pts (5<PR and 4 PD) prior to C4 Rd, 11/13 eligible < VGPR after C6 Rd (1 omission in error, 1 pt WD consent), 4/5 eligible pts < CR after C9 Rd (1 omission in error) and 1 PD at C6]. 18/25 patients have had at least 6 months of Isa intensification with increased depth of response in 12 (66.7%) pts. Of the 9 pts rescued with Isa after not reaching target response post C4 Rd, 7 have completed 6 Isa-Rd cycles with 100% deepening of response (5 PR, 4 VGPR). The overall response rate in the cohort of evaluable patients is 100% (16 PR, 14 VGPR). The median (±SD) follow-up time of the evaluable cohort was 9.96 ± 6.24 months with med OS not reached. Thirty-one (73.8%) pts experienced any grade AE (median = 6; range 1-21). Grade 3 or 4 AEs were reported in 16 pts (34 events in total; median per pt = 2; range 1-5). Most common ³ Grade 3 events include infection (10), neutropenia (7) and insomnia and mood disorder (3 each). Neutropenia was the single grade 4 AE in a patient on Rd. Fewer of the reported grade 3 or 4 AEs occurred while on Isa-Rd (16) than while on Rd alone (n=18) with causality was less frequently attributed to Isa (n=4) than R (n=17) or d (n=14). Conclusion: A response-adapted approach for TNE NDMM pts with isatuximab intensification upon inadequate response to standard-of-care lenalidomide-dexamethasone is both safe and effective. Isa-Rd leads to universal deepening of response in patients failing to achieve a PR or better after 4 months of Rd, while the overall response rate in evaluable patients, irrespective of initial response to Rd, is 100%. Isa-Rd is well tolerated in this elderly patient cohort. The safety profile for the combination Isa-Rd is similar to previous reports. Patient accrual is ongoing. Figure 1: Swimmer's plot highlighting patient response after C4 Rd, timepoints of isatuximab intensification (*Isa) and subsequent depth and duration of response. Figure 1 Figure 1. Disclosures Janowski: Astrazeneca: Membership on an entity's Board of Directors or advisory committees; Regeneron: Membership on an entity's Board of Directors or advisory committees; Amgen: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; Janssen-Cilag: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; BMS/Celgene: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees. Spencer: Celgene: Honoraria, Research Funding, Speakers Bureau; Janssen: Honoraria, Research Funding, Speakers Bureau; Amgen: Honoraria, Research Funding; Bristol Myers Squibb: Research Funding; Takeda: Honoraria, Research Funding, Speakers Bureau; STA: Honoraria. Quach: Takeda: Consultancy, Membership on an entity's Board of Directors or advisory committees; Antengene: Consultancy, Membership on an entity's Board of Directors or advisory committees; Janssen/Cilag: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; GlaxoSmithKline: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Bristol Myers Squibb: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding; Karyopharm: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Celgene: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Sanofi: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding; Amgen: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; CSL: Consultancy, Membership on an entity's Board of Directors or advisory committees.

Neuroacting drugs and its pharmacological response in relation to different stress status: A review

This article intended to review many methods and types of stressors in the previous works of literaturethat describe the role of these stressors to induce modifications and alterations in the pharmacological response of the drugs acting on the nervous system (neuroacting drugs) in human and animal models. The current review focus on the different methods for inducing stress status which categorized as chemical, physical and miscellaneous stressors that affect on the well-known pharmacological response of the neuroacting drugs and by which mechanism can the stressor induce a modification in the drug target response with mentioning the findings related to changes in the pharmcologiacal response of the neuroacting drugs in previous literature. In conclusion, most studies suggest an alteration of the pharmacological response of neuroacting drugs, commonly by potentiating their efficacy and subsequent toxicity, due to different stressful methods, which may be obligated to the direct and indirect receptor modification (pharmacodynamic interaction) in addition to the direct pharmacokinetic influence on the essential parameters of absorption, distribution, metabolism, and excretion of the neuroacting drugs.

Clutter cancellation in passive radar using batch-based CLEAN technique

Passive radar (PR) systems need to detect the presence of a target response, which is many orders of magnitude weaker than the clutter (direct signal and multipath). Indeed, the clutter cancellation is a key stage within a PR processing scheme. One of the most effective techniques in this field is using the CLEAN approach. In this paper, the batch-based CLEAN technique based on GMP and FFT has been proposed, which can speed up the computational processing and have better cancellation gain. Furthermore, segmenting operation can be applied to the signal obtained over long time. It is helpful to enhance temporal or spatial efficiency and overcome effect of time-varying clutter. Experiment results with simulated and real passive radar data verify the effectiveness of the proposed algorithm.

Selection of earthquake ground motion accelerograms for the continental margin of Southeastern Brazil

Brazil is in an intraplate area of low to moderate seismicity, this means that few or no records of strong ground motions are available. Part of the site response analysis and seismic design of structures require the use of acceleration time-histories compatible with a specified target response spectrum. This study aims to utilize methodologies based on the use of existing earthquake records from a well-known database and synthetic accelerograms to obtain ground motions representative of the Brazilian Southeast Region, particularly in the offshore Campos Basin. Information from a probabilistic seismic hazard assessment performed in the interest area was employed as input to the methodologies applied in terms of target response spectrum and the dominant earthquake scenarios. Besides, the acceleration time-histories of two relatively recent earthquakes that occurred in the Brazilian Southeast were used to apply one of the approaches to obtain a synthetic spectrum compatible accelerogram.

The Embodiment of Insult: A Theory of Biobehavioral Response to Workplace Incivility

This article builds a broad theory to explain how people respond, both biologically and behaviorally, when targeted with incivility in organizations. Central to our theorizing is a multifaceted framework that yields four quadrants of target response: reciprocation, retreat, relationship repair, and recruitment of support. We advance the novel argument that these behaviors not only stem from biological change within the body but also stimulate such change. Behavioral responses that revolve around affiliation and produce positive social connections are most likely to bring biological benefits. However, social and cultural features of an organization can stand in the way of affiliation, especially for employees holding marginalized identities. When incivility persists over time and employees lack access to the resources needed to recover, we theorize, downstream consequences can include harms to their physical health. Like other aspects of organizational life, this biobehavioral theory of incivility response is anything but simple. But it may help explain how seemingly “small” insults can sometimes have large effects, ultimately undermining workforce well-being. It may also suggest novel sites for incivility intervention, focusing on the relational and inclusive side of work. The overarching goal of this article is to motivate new science on workplace incivility, new knowledge, and ultimately, new solutions.

Development of an intelligent decision model for non-traditional machining processes

In order to fulfil the ever increasing requirements of various hard and difficult-to-machine materials in automobile, turbine, nuclear, aviation, tool and die making industries, the conventional material removal processes are now being continuously substituted by an array of non-traditional machining (NTM) processes. The efficient and improved capabilities of these NTM processes have made them indispensible for the present day manufacturing industries. While deploying a particular NTM process for a specific machining application, the concerned process engineer must be aware of its capability which is influenced by a large number of controllable parameters. In this paper, an intelligent decision model is designed and developed in VBASIC to guide the concerned process engineer to have an idea about the values of various NTM process responses for a given parametric combination. It would also advise about the tentative settings of different NTM process parameters for achieving a set of target response values. The operational procedure of this developed system is demonstrated with the help of three real time examples.

Effects of the Onset of Differential Reinforcer Quality on Skill Acquisition

Differential reinforcement of a target response is a necessary component of stimulus control transfer procedures. Recent research has further considered the timing (i.e., onset) of differential reinforcement of unprompted correct responding. To date, the onset of differential reinforcement has been inconsistently controlled in studies comparing skill acquisition programs for individuals with developmental disabilities. The current study serves as a systematic replication of prior comparative research to examine the effects of immediate and delayed differential reinforcement onset on the efficiency of acquisition for three individuals with developmental disabilities. The delayed onset of differential reinforcement required the fewest number of exposures to mastery per target across all comparisons. These findings failed to replicate those of prior research on differential reinforcement onset, possibly due to differences in participant characteristics, target tasks, or other required procedural modifications. Considerations for future research on differential reinforcement procedures in skill acquisition programs are described.