scholarly journals Childhood, adolescent and adult age at onset and related clinical correlates in obsessive–compulsive disorder: a report from the International College of Obsessive–Compulsive Spectrum Disorders (ICOCS)

2016 ◽  
Vol 20 (4) ◽  
pp. 210-217 ◽  
Author(s):  
Bernardo Dell’Osso ◽  
Beatrice Benatti ◽  
Eric Hollander ◽  
Naomi Fineberg ◽  
Dan J. Stein ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Age At Onset ◽  
Obsessive Compulsive ◽  
Adult Age ◽  
Compulsive Disorder ◽  
Clinical Correlates ◽  
International College ◽  
Spectrum Disorders

scholarly journals Cigarette smoking in patients with obsessive compulsive disorder: a report from the International College of Obsessive Compulsive Spectrum Disorders (ICOCS)

CNS Spectrums ◽  
2015 ◽  
Vol 20 (5) ◽  
pp. 469-473 ◽  
Author(s):  
Bernardo Dell’Osso ◽  
Humberto Nicolini ◽  
Nuria Lanzagorta ◽  
Beatrice Benatti ◽  
Gregorio Spagnolin ◽  
...  
Keyword(s):  
Cigarette Smoking ◽  
Psychiatric Disorders ◽  
Obsessive Compulsive Disorder ◽  
Tourette’S Syndrome ◽  
Obsessive Compulsive ◽  
Cross Sectional ◽  
Tic Disorder ◽  
Compulsive Disorder ◽  
International College ◽  
Spectrum Disorders

Obsessive compulsive disorder (OCD) showed a lower prevalence of cigarette smoking compared to other psychiatric disorders in previous and recent reports. We assessed the prevalence and clinical correlates of the phenomenon in an international sample of 504 OCD patients recruited through the International College of Obsessive Compulsive Spectrum Disorders (ICOCS) network.Cigarette smoking showed a cross-sectional prevalence of 24.4% in the sample, with significant differences across countries. Females were more represented among smoking patients (16% vs 7%; p<.001). Patients with comorbid Tourette’s syndrome (p<.05) and tic disorder (p<.05) were also more represented among smoking subjects. Former smokers reported a higher number of suicide attempts (p<.05).We found a lower cross-sectional prevalence of smoking among OCD patients compared to findings from previous studies in patients with other psychiatric disorders but higher compared to previous and more recent OCD studies. Geographic differences were found and smoking was more common in females and comorbid Tourette’s syndrome/tic disorder.

Obsessive-Compulsive Disorder and Its Potential Subtypes

CNS Spectrums ◽  
2000 ◽  
Vol 5 (S4) ◽  
pp. 40-46 ◽  
Author(s):  
Donald W. Black
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Serotonin Receptor ◽  
Late Onset ◽  
Age At Onset ◽  
The United States ◽  
Obsessive Compulsive ◽  
Molecular Genetic Study ◽  
Compulsive Disorder ◽  
Eeg Abnormalities ◽  
Spectrum Disorders

AbstractThis manuscript summarizes presentations by an international panel of experts, representing Brazil, Israel, Italy, Mexico, Portugal, Spain, and the United States, at a symposium on obsessive-compulsive disorder (OCD) and its possible subtypes. Presentations concerned both OCD proper, as well as putative obsessive-compulsive-spectrum disorders (autistic disorders, eating disorders, pathological gambling, and schizo-obsessive disorder). Projects discussed included a study assessing impulsive temperament in eating disorder patients, a study on serotonin receptor sensitivity in autism, a study of sleep EEG abnormalities in OCD, a study of dissociation in pathological gamblers, papers on aspects of schizo-obsessive patients, a study addressing biological alterations in OCD, data from a new family study on OCD, data from a molecular genetic study of OCD, a factor analytic study of Tourette disorder, a study hypothesizing the existence of an OCD continuum, and, finally, a paper on early- vs late-onset OCD. General discussion followed leading to a consensus that 1) OCD is likely heterogeneous with multiple subtypes; 2) division of patients by age-at-onset probably represents a robust and valid subtyping scheme; 3) the presence of schizophrenic features probably identifies a valid subtype; 4) the validation of subtypes in the future will be informed by both family-genetic studies, as well as studies of biological alterations in OCD; and 5) the study of obsessive-compulsive spectrum disorders adds to our understanding of the OCD phenomenon, and helps in our search to identify valid subtypes.

scholarly journals Prevalence of suicide attempt and clinical characteristics of suicide attempters with obsessive-compulsive disorder: a report from the International College of Obsessive-Compulsive Spectrum Disorders (ICOCS)

CNS Spectrums ◽  
2017 ◽  
Vol 23 (1) ◽  
pp. 59-66 ◽  
Author(s):  
Bernardo Dell’Osso ◽  
Beatrice Benatti ◽  
Chiara Arici ◽  
Carlotta Palazzo ◽  
A. Carlo Altamura ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Suicide Attempt ◽  
Obsessive Compulsive Disorder ◽  
Clinical Features ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
International College ◽  
History Of ◽  
Spectrum Disorders ◽  
The Impact

ObjectiveObsessive-compulsive disorder (OCD) is associated with variable risk of suicide and prevalence of suicide attempt (SA). The present study aimed to assess the prevalence of SA and associated sociodemographic and clinical features in a large international sample of OCD patients.MethodsA total of 425 OCD outpatients, recruited through the International College of Obsessive-Compulsive Spectrum Disorders (ICOCS) network, were assessed and categorized in groups with or without a history of SA, and their sociodemographic and clinical features compared through Pearson’s chi-squared and t tests. Logistic regression was performed to assess the impact of the collected data on the SA variable.Results14.6% of our sample reported at least one SA during their lifetime. Patients with an SA had significantly higher rates of comorbid psychiatric disorders (60 vs. 17%, p<0.001; particularly tic disorder), medical disorders (51 vs. 15%, p<0.001), and previous hospitalizations (62 vs. 11%, p<0.001) than patients with no history of SA. With respect to geographical differences, European and South African patients showed significantly higher rates of SA history (40 and 39%, respectively) compared to North American and Middle-Eastern individuals (13 and 8%, respectively) (χ2=11.4, p<0.001). The logistic regression did not show any statistically significant predictor of SA among selected independent variables.ConclusionsOur international study found a history of SA prevalence of ~15% in OCD patients, with higher rates of psychiatric and medical comorbidities and previous hospitalizations in patients with a previous SA. Along with potential geographical influences, the presence of the abovementioned features should recommend additional caution in the assessment of suicide risk in OCD patients.

scholarly journals Lifetime bipolar disorder comorbidity and related clinical characteristics in patients with primary obsessive compulsive disorder: a report from the International College of Obsessive–Compulsive Spectrum Disorders (ICOCS)

CNS Spectrums ◽  
2019 ◽  
Vol 25 (3) ◽  
pp. 419-425 ◽  
Author(s):  
Bernardo Dell’Osso ◽  
Matteo Vismara ◽  
Beatrice Benatti ◽  
Giovanna Cirnigliaro ◽  
Benedetta Grancini ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Obsessive Compulsive Disorder ◽  
Clinical Characteristics ◽  
Primary Diagnosis ◽  
International Studies ◽  
Obsessive Compulsive ◽  
Course Of Illness ◽  
Compulsive Disorder ◽  
International College ◽  
Spectrum Disorders

Introduction.Bipolar disorder (BD) and obsessive compulsive disorder (OCD) are prevalent, comorbid, and disabling conditions, often characterized by early onset and chronic course. When comorbid, OCD and BD can determine a more pernicious course of illness, posing therapeutic challenges for clinicians. Available reports on prevalence and clinical characteristics of comorbidity between BD and OCD showed mixed results, likely depending on the primary diagnosis of analyzed samples.Methods.We assessed prevalence and clinical characteristics of BD comorbidity in a large international sample of patients with primary OCD (n = 401), through the International College of Obsessive–Compulsive Spectrum Disorders (ICOCS) snapshot database, by comparing OCD subjects with vs without BD comorbidity.Results.Among primary OCD patients, 6.2% showed comorbidity with BD. OCD patients with vs without BD comorbidity more frequently had a previous hospitalization (p < 0.001) and current augmentation therapies (p < 0.001). They also showed greater severity of OCD (p < 0.001), as measured by the Yale–Brown Obsessive Compulsive Scale (Y-BOCS).Conclusion.These findings from a large international sample indicate that approximately 1 out of 16 patients with primary OCD may additionally have BD comorbidity along with other specific clinical characteristics, including more frequent previous hospitalizations, more complex therapeutic regimens, and a greater severity of OCD. Prospective international studies are needed to confirm our findings.

scholarly journals Obsessive–Compulsive Disorder Across the Developmental Trajectory: Clinical Correlates in Children, Adolescents and Adults

2006 ◽  
Vol 23 (2) ◽  
pp. 103-120 ◽  
Author(s):  
Lara Farrell ◽  
Paula Barrett ◽  
John Piacentini
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Familial Aggregation ◽  
Age At Onset ◽  
Age Groups ◽  
Developmental Trajectory ◽  
Childhood And Adolescence ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Clinical Correlates ◽  
Adolescents And Adults

AbstractPrevious research examining the clinical phenomenology of obsessive–compulsive disorder (OCD) has provided some evidence that OCD might be associated with different clinical correlates at different stages of development. In particular, there appears to be a bimodal distribution in terms of the age of onset of the disorder, a male predominance during childhood and adolescence compared to adulthood, stronger familial aggregation of OCD in early onset cases, and differences in the types of symptoms and the patterns of comorbidity across age groups. This study assessed the continuity in clinical presentation of OCD across three distinct age groups: children, adolescents and adults. It was hypothesised that the sample of children would be predominantly male, and would have a higher familial aggregation of OCD and/or anxiety/depression in first-degree relatives. It was further hypothesised that there would be significant age-related differences in terms of specific symptoms, patterns of comorbidity, OCD severity, functional impairment, and level of insight and distress. The results of this study support the developmental heterogeneity hypothesis, with significant differences occurring across age groups on a number of clinical features of OCD including age at onset, symptoms experienced, comorbidity, severity, insight and impairment. Implications of the findings and future directions for research in this area are discussed.

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