Association between white matter organization and cognitive performance in athletes with a history of sport-related concussion

AbstractAs maturation of the brain continues throughout development, there is a risk of interference from concussions which are common in childhood. A concussion can cause widespread disruption to axons and inflammation in the brain and may influence emerging cognitive abilities. Females are more likely to experience persistent problems after a concussion, yet the sex-specific impact of concussions on brain microstructure in childhood is not well understood.In children from a large population sample, this study (1) investigated differences in white matter and cortical microstructure between children with and without a history of concussion, and (2) examined relationships between altered brain microstructure and cognitive performance.Neurite density measures from diffusion weighted magnetic resonance imaging were examined in 9-to 10-year-old children in the Adolescent Brain Cognitive Development Study with (n = 336) and without (n = 7368) a history of concussion. (1) Multivariate regression models were used to investigate the relationships between concussion history, sex, and age in the deep white matter, superficial white matter, subcortical structures, and cortex. (2) Principal component analysis was performed on neurite density, and components were examined in relation to performance on the Flanker Inhibitory Control and Attention Task and the Pattern Comparison Processing Speed Task to investigate the relationship between altered neurite density and cognitive performance.Neurite density in all tissue types demonstrated robust positive relationships with age reflecting maturation of brain microstructure. (1) Comparisons between children with and without a history of concussion revealed higher neurite density in deep and superficial white matter in females with concussion. No group differences were observed in subcortical or cortical neurite density. (2) Higher neurite density in superficial white matter beneath the frontal and temporal cortices was associated with lower scores on the processing speed test in females with concussion, and higher scores on the processing speed test in males with concussion.These findings suggest that concussion in childhood leads to premature white matter maturation in females and that this may be associated with slower processing speed. These sex-specific effects on the developing brain may contribute to the enhanced vulnerability to persistent symptoms after concussion in females.

Download Full-text

Sustained Opening of the Blood-Brain Barrier with Progressive Accumulation of White Matter Hyperintensities Following Ischemic Stroke

Brain Sciences ◽

10.3390/brainsci9010016 ◽

2019 ◽

Vol 9 (1) ◽

pp. 16 ◽

Cited By ~ 2

Author(s):

Imama Naqvi ◽

Emi Hitomi ◽

Richard Leigh

Keyword(s):

Ischemic Stroke ◽

White Matter ◽

Acute Stroke ◽

Blood Brain Barrier ◽

White Matter Hyperintensities ◽

Brain Barrier ◽

Common Finding ◽

Blood Brain ◽

History Of ◽

Iv Tpa

Objective: To report a patient in whom an acute ischemic stroke precipitated chronic blood-brain barrier (BBB) disruption and expansion of vascular white matter hyperintensities (WMH) into regions of normal appearing white matter (NAWM) during the following year. Background: WMH are a common finding in patients with vascular risk factors such as a history of stroke. The pathophysiology of WMH is not fully understood; however, there is growing evidence to suggest that the development of WMH may be preceded by the BBB disruption in the NAWM. Methods: We studied a patient enrolled in the National Institutes of Health Natural History of Stroke Study who was scanned with magnetic resonance imaging (MRI) after presenting to the emergency room with an acute stroke. After a treatment with IV tPA, she underwent further MRI scanning at 2 h, 24 h, 5 days, 30 days, 90 days, 6 months, and 1-year post stroke. BBB permeability images were generated from the perfusion weighted imaging (PWI) source images. MRIs from each time point were co-registered to track changes in BBB disruption and WMH over time. Results: An 84-year-old woman presented after acute onset right hemiparesis, right-sided numbness and aphasia with an initial NIHSS of 13. MRI showed diffusion restriction in the left frontal lobe and decreased blood flow on perfusion imaging. Fluid attenuated inversion recovery (FLAIR) imaging showed bilateral confluent WMH involving the deep white matter and periventricular regions. She was treated with IV tPA without complication and her NIHSS improved initially to 3 and ultimately to 0. Permeability maps identified multiple regions of chronic BBB disruption remote from the acute stroke, predominantly spanning the junction of WMH and NAWM. The severity of BBB disruption was greatest at 24 h after the stroke but persisted on subsequent MRI scans. Progression of WMH into NAWM over the year of observation was detected bilaterally but was most dramatic in the regions adjacent to the initial stroke. Conclusions: WMH-associated BBB disruption may be exacerbated by an acute stroke, even in the contralateral hemisphere, and can persist for months after the initial event. Transformation of NAWM to WMH may be evident in areas of BBB disruption within a year after the stroke. Further studies are needed to investigate the relationship between chronic BBB disruption and progressive WMH in patients with a history of cerebrovascular disease and the potential for acute stroke to trigger or exacerbate the process leading to the development of WMH.

Download Full-text

A history of previous childbirths is linked to women's white matter brain age in midlife and older age

Human Brain Mapping ◽

10.1002/hbm.25553 ◽

2021 ◽

Author(s):

Irene Voldsbekk ◽

Claudia Barth ◽

Ivan I. Maximov ◽

Tobias Kaufmann ◽

Dani Beck ◽

...

Keyword(s):

White Matter ◽

Older Age ◽

History Of ◽

Brain Age

Download Full-text

CHARACTERIZATION OF COGNITIVE PERFORMANCE, GRAY MATTER VOLUME AND WHITE MATTER MICROSTRUCTURE IN COGNITIVELY UNIMPAIRED ADULTS WITH INSOMNIA SYMPTOMS

Alzheimer s & Dementia ◽

10.1016/j.jalz.2019.06.4549 ◽

2019 ◽

Vol 15 (7) ◽

pp. P207-P209

Author(s):

Oriol Grau-Rivera ◽

Grégory Operto ◽

Carles Falcon ◽

Raffaele Cacciaglia ◽

Gonzalo Sánchez-Benavides ◽

...

Keyword(s):

White Matter ◽

Cognitive Performance ◽

Gray Matter ◽

Gray Matter Volume ◽

Matter Volume ◽

White Matter Microstructure ◽

Insomnia Symptoms

Download Full-text

White matter integrity and functional connectivity in adolescents with a parental history of substance use disorder

Neuroimage: Reports ◽

10.1016/j.ynirp.2021.100037 ◽

2021 ◽

Vol 1 (3) ◽

pp. 100037

Author(s):

Xiaofu He ◽

Diana V. Rodriguez-Moreno ◽

Yael M. Cycowicz ◽

Keely Cheslack-Postava ◽

Huilan Tang ◽

...

Keyword(s):

Substance Use ◽

White Matter ◽

Functional Connectivity ◽

Substance Use Disorder ◽

White Matter Integrity ◽

Parental History ◽

History Of

Download Full-text

Surface-based cortical morphometry, white matter hyperintensity, and multidomain cognitive performance in asymptomatic carotid stenosis

Neuroscience ◽

10.1016/j.neuroscience.2021.05.013 ◽

2021 ◽

Author(s):

Lei Gao ◽

Zhao Ruan ◽

Yaqiong Xiao ◽

Haibo Xu

Keyword(s):

White Matter ◽

Carotid Stenosis ◽

Cognitive Performance ◽

White Matter Hyperintensity ◽

Asymptomatic Carotid Stenosis ◽

Asymptomatic Carotid ◽

Cortical Morphometry

Download Full-text

Modeling the Relationship among Gray Matter Atrophy, Abnormalities in Connecting White Matter, and Cognitive Performance in Early Multiple Sclerosis

American Journal of Neuroradiology ◽

10.3174/ajnr.a4165 ◽

2014 ◽

Vol 36 (4) ◽

pp. 702-709 ◽

Cited By ~ 14

Author(s):

A.F. Kuceyeski ◽

W. Vargas ◽

M. Dayan ◽

E. Monohan ◽

C. Blackwell ◽

...

Keyword(s):

Multiple Sclerosis ◽

White Matter ◽

Cognitive Performance ◽

Gray Matter ◽

Gray Matter Atrophy ◽

The Relationship

Download Full-text

Delirium, depression, and long-term cognition

International Psychogeriatrics ◽

10.1017/s1041610221002556 ◽

2021 ◽

pp. 1-6

Author(s):

Patricia S. Andrews ◽

Jennifer Thompson ◽

Rameela Raman ◽

Chelsea Rick ◽

Amy Kiehl ◽

...

Keyword(s):

Cognitive Performance ◽

Prior History ◽

Depression Symptom ◽

Neuropsychological Status ◽

Beta Coefficient ◽

History Of ◽

Surgical Icu ◽

Depression History ◽

History Of Depression

ABSTRACT Objectives: We examined whether preadmission history of depression is associated with less delirium/coma-free (DCF) days, worse 1-year depression severity and cognitive impairment. Design and measurements: A health proxy reported history of depression. Separate models examined the effect of preadmission history of depression on: (a) intensive care unit (ICU) course, measured as DCF days; (b) depression symptom severity at 3 and 12 months, measured by the Beck Depression Inventory-II (BDI-II); and (c) cognitive performance at 3 and 12 months, measured by the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) global score. Setting and participants: Patients admitted to the medical/surgical ICU services were eligible. Results: Of 821 subjects eligible at enrollment, 261 (33%) had preadmission history of depression. After adjusting for covariates, preadmission history of depression was not associated with less DCF days (OR 0.78, 95% CI, 0.59–1.03 p = 0.077). A prior history of depression was associated with higher BDI-II scores at 3 and 12 months (3 months OR 2.15, 95% CI, 1.42–3.24 p = <0.001; 12 months OR 1.89, 95% CI, 1.24–2.87 p = 0.003). We did not observe an association between preadmission history of depression and cognitive performance at either 3 or 12 months (3 months beta coefficient −0.04, 95% CI, −2.70–2.62 p = 0.97; 12 months 1.5, 95% CI, −1.26–4.26 p = 0.28). Conclusion: Patients with a depression history prior to ICU stay exhibit a greater severity of depressive symptoms in the year after hospitalization.

Download Full-text

Abstract TP201: The Relationship Between Chronic Kidney Diseases and the Presence of Cerebral Small Vessel Disease in Patients With Acute Ischemic Stroke

Stroke ◽

10.1161/str.48.suppl_1.tp201 ◽

2017 ◽

Vol 48 (suppl_1) ◽

Author(s):

Kana Ueki ◽

Asako Nakamura ◽

Masahiro Yasaka ◽

Takahiro Kuwashiro ◽

Seiji Gotoh ◽

...

Keyword(s):

Ischemic Stroke ◽

White Matter ◽

Acute Ischemic Stroke ◽

White Matter Lesion ◽

Kidney Diseases ◽

Univariate Analysis ◽

Small Vessel ◽

Chronic Kidney Diseases ◽

History Of ◽

The Relationship

Introduction: Cerebral small vessel diseases (SVDs) i.e. white matter lesion and cerebral microbleeds (CMBs) are related to the patients with stroke more deeply than those without. In general population, in addition to age, hypertension, diabetes chronic kidney diseases (CKD) is well known to be related to SVDs, but it remains unclear in patients with stroke. We investigated the relationship between CKD and the presence of SVDs in patients with acute ischemic stroke. Methods: We enrolled 493 patients with acute ischemic stroke patients or transient ischemic attack patients (mean age 71; 60% male) who had undergone 1.5T MR imaging within a week of the index events from April 2013 to march 2015. We evaluated kidney function by estimated glomerular filtration rate (eGFR) with the modification of diet in Renal Disease. CKD was defined as an eGFR less than 60mil/min/1.73m 2 . CMBs were defined as focal areas of very low signal intensity smaller than 10mm. White matter lesion as Periventricular hyper intensity (PVH)>grade 2 and Deep and Subcortical White Matter Hyper intensity (DSWMH)> grade 2 were defied as advanced PVH and advanced DSWMH, respectively. We investigated relationship between CKD and CMBs, advanced PVH and advanced DSWMH using a logistic regression analysis. Results: We noted CMBs in 173 patients (35%), PVH in 81 (16%), and DSWMH in 151 (31%). An univariate analysis revealed that the age, CKD, history of stroke, and antiplatelet agents were associated with presence of CMBs, advanced PVH and severe DSWMH . The multivariate analysis revealed that CMBs, advanced PVH and advanced DSWMH were associated with age (CMBs: odds ratio(OR) ; 1.32 ; 95% confidence interval(CI), 1.10-1.60, p=0.004, advanced PVH : OR ; 3.00 ; 95% CI, 2.17-4.26, p<0.01, advanced DSWMH: OR ; 1.94; 95% CI, 1.56-2.45, p<0.01 ), history of stroke(CMBs : OR ; 2.01 ; 95% CI, 1.21-3.34, p=0.007, advanced PVH : OR ; 2.25 ; 95% CI, 1.18-4.27, p=0.01, advanced DSWMH: OR ; 1.78 ; 95% CI, 1.03-3.06, p=0.038). CKD was associated with CMBs (OR ; 1.62 ; 95% CI, 1.04-2.52, p=0.03), but PVH and DSWMH were not. Conclusions: It seems that age and history of stroke are related to CMBs, advanced PVH and advanced DSWMH, and that CKD is associates with CMBs but not with either advanced PVH or advanced DSWMH.

Download Full-text