MBTPS2 exacerbates albuminuria in streptozotocin-induced type I diabetic nephropathy by promoting endoplasmic reticulum stress-mediated renal damage

2020 ◽  
pp. 1-8 ◽  
Author(s):  
Yongliang Liu ◽  
Dayu Xu ◽  
Linping Wang ◽  
Wenyan Du ◽  
Limei Zhang ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Diabetic Nephropathy ◽  
Endoplasmic Reticulum Stress ◽  
Renal Damage ◽  
Type I

scholarly journals Ligustrazine attenuates renal damage by inhibiting endoplasmic reticulum stress in diabetic nephropathy by inactivating MAPK pathways

RSC Advances ◽  
2018 ◽  
Vol 8 (39) ◽  
pp. 21816-21822 ◽  
Author(s):  
Hongling Yang ◽  
Shukun Wu
Keyword(s):  
Chronic Kidney Disease ◽  
Endoplasmic Reticulum ◽  
Diabetic Nephropathy ◽  
Kidney Disease ◽  
Endoplasmic Reticulum Stress ◽  
Renal Damage ◽  
Mapk Pathways ◽  
The World

Diabetic nephropathy (DN) is a major cause of chronic kidney disease around the world.

scholarly journals Retraction: Ligustrazine attenuates renal damage by inhibiting endoplasmic reticulum stress in diabetic nephropathy by inactivating MAPK pathways

RSC Advances ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 4165-4165
Author(s):  
Laura Fisher
Keyword(s):  
Endoplasmic Reticulum ◽  
Diabetic Nephropathy ◽  
Endoplasmic Reticulum Stress ◽  
Renal Damage ◽  
Mapk Pathways

Retraction of ‘Ligustrazine attenuates renal damage by inhibiting endoplasmic reticulum stress in diabetic nephropathy by inactivating MAPK pathways’ by Hongling Yang et al., RSC Adv., 2018, 8, 21816–21822, DOI: 10.1039/C8RA01674G.

scholarly journals An essential dimer-forming subregion of the endoplasmic reticulum stress sensor Ire1

2005 ◽  
Vol 391 (1) ◽  
pp. 135-142 ◽  
Author(s):  
Daisuke Oikawa ◽  
Yukio Kimata ◽  
Masato Takeuchi ◽  
Kenji Kohno
Keyword(s):  
Endoplasmic Reticulum ◽  
Recombinant Protein ◽  
Endoplasmic Reticulum Stress ◽  
Transmembrane Protein ◽  
Type I ◽  
Unfolded Protein ◽  
The Unfolded Protein Response ◽  
Protein Response ◽  
Recombinant Fragments ◽  
Made In

The luminal domain of the type I transmembrane protein Ire1 senses endoplasmic reticulum stress by an undefined mechanism to up-regulate the signalling pathway for the unfolded protein response. Previously, we proposed that the luminal domain of yeast Ire1 is divided into five subregions, termed subregions I–V sequentially from the N-terminus. Ire1 lost activity when internal deletions of subregion II or IV were made. In the present paper, we show that partial proteolysis of a recombinant protein consisting of the Ire1 luminal domain suggests that subregions II–IV are tightly folded. We also show that a recombinant protein of subregions II–IV formed homodimers, and that this homodimer formation was impaired by an internal deletion of subregion IV. Furthermore, recombinant fragments of subregion IV exhibited a self-binding ability. Therefore, although its sequence is little conserved evolutionarily, subregion IV plays an essential role to promote Ire1 dimer formation.

scholarly journals EGFR inhibition attenuates diabetic nephropathy through decreasing ROS and endoplasmic reticulum stress

Oncotarget ◽  
2017 ◽  
Vol 8 (20) ◽  
pp. 32655-32667 ◽  
Author(s):  
Zheng Xu ◽  
Yunjie Zhao ◽  
Peng Zhong ◽  
Jingying Wang ◽  
Qiaoyou Weng ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Diabetic Nephropathy ◽  
Endoplasmic Reticulum Stress ◽  
Egfr Inhibition

scholarly journals Rtn1a-Mediated Endoplasmic Reticulum Stress in Podocyte Injury and Diabetic Nephropathy

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Ying Fan ◽  
Jing Zhang ◽  
Wenzhen Xiao ◽  
Kyung Lee ◽  
Zhengzhe Li ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Diabetic Nephropathy ◽  
Endoplasmic Reticulum Stress ◽  
Podocyte Injury
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