Short-term outcome of brainstem auditory function in term infants after discharge from the neonatal intensive care unit

2017 ◽  
Vol 31 (17) ◽  
pp. 2231-2236
Author(s):  
Ze Dong Jiang ◽  
Chao Chen
2017 ◽  
Vol 4 (2) ◽  
pp. 620
Author(s):  
Pramila Verma ◽  
Ashish Kalraiya

Background: Worldwide approximately one million babies die per year due to asphyxia out of which about one third (approximately 3 lakhs) is contributed by our country. The objective of this study was to determine the requirement of respiratory support in newborn babies and their short-term outcomes.Methods: This retrospective observational study was conducted over one year at PCMS and RC Bhopal. Babies who were delivered in PCMS and required respiratory support at birth were enrolled in the study. The medical records of all these babies for resuscitation measures, requirement of respiratory support after hospitalization to the neonatal intensive care unit and their short-term outcome were recorded on a pre-designed study proforma.Results: During post-resuscitation care in neonatal intensive care unit, 55.5% (30/54) babies required respiratory support. Among them 7.4% (4/54) were supplemented with oxygen for a few hrs, 22.2% (12/54) required positive end expiratory pressure and put on high flow oxygen and air mixture for 24-48 hours. While 25.9% (14/54) newborns required mechanical ventilation for 3-7 days and then switched over to CPAP for the next 24-48 hrs. Out of 54 babies eight babies expired while ten babies went against medical advice. Remaining 36 babies were discharged, of which five babies developed hypoxic ishchaemic encephalopathy.Conclusions: It is evident from the present study that half of the resuscitated babies further required respiratory support in the NICU. We also concluded that three fourth of the newborns were discharged and had normal short term outcome.


2019 ◽  
Vol 70 (12) ◽  
pp. 2553-2560
Author(s):  
Ashley M Rooney ◽  
Kathryn Timberlake ◽  
Kevin A Brown ◽  
Saumya Bansal ◽  
Christopher Tomlinson ◽  
...  

Abstract Background Discontinuation of inappropriate antimicrobial therapy is an important target for stewardship intervention. The drug and duration-dependent effects of antibiotics on the developing neonatal gut microbiota needs to be precisely quantified. Methods In this retrospective, cross-sectional study, we performed 16S rRNA sequencing on stool swab samples collected from neonatal intensive care unit patients within 7 days of discontinuation of therapy who received ampicillin and tobramycin (AT), ampicillin and cefotaxime (AC), or ampicillin, tobramycin, and metronidazole (ATM). We compared taxonomic composition within term and preterm infant groups between treatment regimens. We calculated adjusted effect estimates for antibiotic type and duration of therapy on the richness of obligate anaerobes and known butyrate-producers in all infants. Results A total of 72 infants were included in the study. Term infants received AT (20/28; 71%) or AC (8/28; 29%) with median durations of 3 and 3.5 days, respectively. Preterm infants received AT (32/44; 73%) or ATM (12/44; 27%) with median durations of 4 and 7 days, respectively. Compositional analyses of 67 stool swab samples demonstrated low diversity and dominance by potential pathogens. Within 1 week of discontinuation of therapy, each additional day of antibiotics was associated with lower richness of obligate anaerobes (adjusted risk ratio [aRR], 0.84; 95% confidence interval [CI], .73–.95) and butyrate-producers (aRR, 0.82; 95% CI, .67–.97). Conclusions Each additional day of antibiotics was associated with lower richness of anaerobes and butyrate-producers within 1 week after therapy. A longitudinally sampled cohort with preexposure sampling is needed to validate our results.


2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
O. H. Hernandez ◽  
J. F. Zapata ◽  
M. Jimenez ◽  
M. Massaro ◽  
A. Guerra ◽  
...  

Introduction. Refractory status epilepticus (RSE) has significant morbidity and mortality, and its management requires an accurate diagnosis and aggressive treatment. Objectives. To describe the experience of management of RSE in a neurological intensive care unit (NeuroICU) and determine predictors of short-term clinical outcome. Methods. We reviewed cases of RSE from September 2007 to December 2008. Management was titrated to findings on continuous video EEG (cVEEG). We collected patients’ demographics, RSE etiology, characteristics of seizures, cVEEG findings, treatments, and short-term outcome. Control of RSE was to achieve burst suppression pattern or electrographic cessation of ictal activity. Results. We included 80 patients; 63.8% were in coma, 25% had subclinical seizures, and 11.3% had focal activity. 51.3% were male and mean age was 45 years. Etiology was neurological lesion in 75.1%, uncontrolled epilepsy in 20%, and systemic derangements in 4.9%. 78.8% were treated with general anesthesia and concomitant anticonvulsant drugs. The control of RSE was 87.5% of patients. In-hospital mortality was 22.5%. The factors associated with unfavorable short-term outcome were coma and age over 60 years. Conclusions. RSE management guided by cVEEG is associated with a good seizure control. A multidisciplinary approach can help achieve a better short-term functional outcome in noncomatose patients.


2019 ◽  
Vol 37 (14) ◽  
pp. 1455-1461
Author(s):  
Kaashif A. Ahmad ◽  
Steven G. Velasquez ◽  
Katy L. Kohlleppel ◽  
Cody L. Henderson ◽  
Christina N. Stine ◽  
...  

Objectives This study aimed to describe the variation of in-neonatal intensive care unit (NICU) cardiopulmonary resuscitation (CPR) characteristics and outcomes across different gestational ages and levels of NICU care. Study Design This is a retrospective cohort study of in-NICU CPR events across 10 NICUs in San Antonio, TX from 2012 through 2017. Results We identified 140 patients experiencing a total of 210 in-NICU CPR events. CPR was performed in 0.23% of Level III and 0.85% of Level IV NICU admissions. Gestational age was inversely related to CPR incidence. The median age at in-NICU CPR was lower for preterm versus term infants (6 vs. 28 days, p = 0.002). With regression modeling, each added minute of chest compression decreased the odds of return to spontaneous circulation by 11%. Conclusion In-NICU CPR incidence rises with decreasing gestational age and increasing level of NICU care. The rate of return of spontaneous circulation decreases significantly with increasing duration of chest compressions. Further study is needed to identify patient factors associated with adverse outcome.


2021 ◽  
Vol 24 (5) ◽  
pp. 397-404
Author(s):  
Mohammadbagher Hosseini ◽  
Azizeh Farshbaf-Khalili ◽  
Atefe Seyyedzavvar ◽  
Nazila Fuladi ◽  
Nafiseh Hosseini ◽  
...  

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