Does Calcium in Drinking Water Modify the Association Between Trihalomethanes and the Risk of Death from Colon Cancer?

2010 ◽  
Vol 73 (10) ◽  
pp. 657-668 ◽  
Author(s):  
Hsin-Wei Kuo ◽  
Mao-Meng Tiao ◽  
Shang-Shyue Tsai ◽  
Trong-Neng Wu ◽  
Chun-Yuh Yang
Keyword(s):  
Colon Cancer ◽  
Drinking Water ◽  
Risk Of Death

scholarly journals Calcium and Magnesium in Drinking Water and Risk of Death from Colon Cancer

1997 ◽  
Vol 88 (10) ◽  
pp. 928-933 ◽  
Author(s):  
Chun-Yuh Yang ◽  
Hui-Fen Chiu ◽  
Jeng-Fen Chiu ◽  
Shang-Shyue Tsai ◽  
Ming-Fen Cheng
Keyword(s):  
Colon Cancer ◽  
Drinking Water ◽  
Risk Of Death ◽  
Calcium And Magnesium

scholarly journals Does calcium in drinking water modify the association between nitrate in drinking water and risk of death from colon cancer?

2011 ◽  
Vol 9 (3) ◽  
pp. 498-506 ◽  
Author(s):  
Hui-Fen Chiu ◽  
Shang-Shyue Tsai ◽  
Pei-Shih Chen ◽  
Trong-Neng Wu ◽  
Chun-Yuh Yang
Keyword(s):  
Colon Cancer ◽  
Drinking Water ◽  
Vital Statistics ◽  
Risk Of Death ◽  
Department Of Health ◽  
Colon Cancer Risk ◽  
Matched Case ◽  
Colon Cancer Mortality ◽  
The Relationship ◽  
Control Study

The objective of this study was to explore whether calcium (Ca) levels in drinking water modified the effects of nitrate on colon cancer risk. A matched case–control study was used to investigate the relationship between the risk of death from colon cancer and exposure to nitrate in drinking water in Taiwan. All colon cancer deaths of Taiwan residents from 2003 through 2007 were obtained from the Bureau of Vital Statistics of the Taiwan Provincial Department of Health. Controls were deaths from other causes and were pair-matched to the cases by gender, year of birth and year of death. Information on the levels of nitrate-nitrogen (NO3-N) and Ca in drinking water have been collected from Taiwan Water Supply Corporation (TWSC). The municipality of residence for cases and controls was assumed to be the source of the subject's NO3-N and Ca exposure via drinking water. We observed evidence of an interaction between drinking water NO3-N and Ca intake via drinking water. This is the first study to report effect modification by Ca intake from drinking water on the association between NO3-N exposure and risk of colon cancer mortality.

Magnesium in Drinking Water Modifies the Association Between Trihalomethanes and the Risk of Death From Colon Cancer

2011 ◽  
Vol 74 (6) ◽  
pp. 392-403 ◽  
Author(s):  
Hsin-Wei Kuo ◽  
Chiung-Yu Peng ◽  
Anne Feng ◽  
Trong-Neng Wu ◽  
Chun-Yuh Yang
Keyword(s):  
Colon Cancer ◽  
Drinking Water ◽  
Risk Of Death

Nitrate in drinking water and risk of death from colon cancer in Taiwan

2007 ◽  
Vol 33 (5) ◽  
pp. 649-653 ◽  
Author(s):  
Chun-Yuh Yang ◽  
Deng-Chuang Wu ◽  
Chih-Ching Chang
Keyword(s):  
Colon Cancer ◽  
Drinking Water ◽  
Risk Of Death

Trihalomethanes in Drinking Water and the Risk of Death from Colon Cancer in Taiwan

2009 ◽  
Vol 72 (20) ◽  
pp. 1217-1222 ◽  
Author(s):  
Hsin-Wei Kuo ◽  
Mao-Meng Tiao ◽  
Trong-Neng Wu ◽  
Chun-Yuh Yang
Keyword(s):  
Colon Cancer ◽  
Drinking Water ◽  
Risk Of Death

scholarly journals INFORM: INFrared-based ORganizational Measurements of tumor and its microenvironment to predict patient survival

2021 ◽  
Vol 7 (6) ◽  
pp. eabb8292
Author(s):  
Saumya Tiwari ◽  
Andre Kajdacsy-Balla ◽  
Joshua Whiteley ◽  
Georgina Cheng ◽  
Stephen M. Hewitt ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Progression ◽  
Spatial Organization ◽  
Infrared Imaging ◽  
Patient Survival ◽  
High Definition ◽  
Risk Of Death ◽  
Measurement Framework ◽  
Spatially Varying ◽  
Physical And Chemical

The structure and organization of a tumor and its microenvironment are often associated with cancer outcomes due to spatially varying molecular composition and signaling. A persistent challenge is to use this physical and chemical spatial organization to understand cancer progression. Here, we present a high-definition infrared imaging–based organizational measurement framework (INFORM) that leverages intrinsic chemical contrast of tissue to label unique components of the tumor and its microenvironment. Using objective and automated computational methods, further, we determine organization characteristics important for prediction. We show that the tumor spatial organization assessed with this framework is predictive of overall survival in colon cancer that adds to capability from clinical variables such as stage and grade, approximately doubling the risk of death in high-risk individuals. Our results open an all-digital avenue for measuring and studying the association between tumor spatial organization and disease progression.

scholarly journals Taurine Attenuates Carcinogenicity in Ulcerative Colitis-Colorectal Cancer Mouse Model

2020 ◽  
Vol 2020 ◽  
pp. 1-7 ◽  
Author(s):  
Guifeng Wang ◽  
Ning Ma ◽  
Feng He ◽  
Shosuke Kawanishi ◽  
Hatasu Kobayashi ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Drinking Water ◽  
Mouse Model ◽  
Histopathological Examination ◽  
Tumor Formation ◽  
Water Model ◽  
Control Group ◽  
Ki 67

Taurine (2-aminoethane-sulfonic acid) is a type of amino acids and has numerous physiological and therapeutic functions, including anti-inflammation. However, there are few studies on the anticancer action of taurine. Our previous studies have demonstrated that taurine exhibits an apoptosis-inducing effect on human nasopharyngeal carcinoma cells in vitro. In this study, we have investigated whether taurine has an anticancer effect, using azoxymethane (AOM)/sulfate sodium (DSS)- induced mouse model for colon carcinogenesis. All mice, except those in control group, received a single intraperitoneal injection of AOM and DSS in the drinking water for 7 days twice, with 1-week interval. After the first DSS treatment, mice were given distilled water (model group) or taurine in the drinking water (taurine group) ad libitum. No tumor was observed in the control group. Taurine significantly suppressed AOM+DSS-induced tumor formation. Histopathological examination revealed AOM/DSS treatment induced colon cancer in all mice (8/8, 100%), and taurine significantly inhibited the progression of colon cancer (4/9, 44.4%). Taurine significantly attenuated cell proliferation in cancer tissues detected by Ki-67 staining. Taurine significantly increased the levels of an apoptosis marker cleaved caspase-9 and tumor suppressor protein PTEN. This is the first study that demonstrated that taurine significantly reduced carcinogenicity in vivo using AOM/DSS-induced colon cancer mouse model.

scholarly journals Clinical Management of Localized Colon Cancer with Capecitabine

2012 ◽  
Vol 6 ◽  
pp. CMO.S8194 ◽  
Author(s):  
J. Quidde ◽  
D. Arnold ◽  
A. Stein
Keyword(s):  
Colon Cancer ◽  
Oral Route ◽  
Risk Of Death ◽  
Randomized Controlled ◽  
Active Moiety ◽  
Equivalent Efficacy ◽  
Primary Colon Cancer ◽  
Primary Colon ◽  
Inhibition Of Dna Synthesis ◽  
The Impact

Large randomized trials demonstrated a benefit of adjuvant chemotherapy after resection of the primary colon cancer. It improves overall survival and reduces the risk of death, by 5% in UICC (Union Internationale Contre le Cancer) stage II and approximately 15%–20% in stage III. Fluoropyrimidines have been the standard drugs for the treatment of colon cancer since large randomized controlled trials demonstrated their efficacy and safety in treating patients suffering from this disease. Capecitabine is an orally administered fluoropyrimidine, which is preferably activated in tumor tissue to the active moiety 5-fluorouracil (5FU) and is cytotoxic through inhibition of DNA synthesis. It has proven equivalent efficacy and tolerability despite a changed toxicity profile compared to 5FU with less myelosuppression but more hand-and-foot syndrome. Capecitabine is well tolerated in elderly patients. The oral route of administration avoids frequent clinical visits as well as insertion of central venous catheters. The impact of the particular drug features on daily clinical practice is discussed in this review.

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