scholarly journals Demystifying the challenges and barriers to manage, develop, and transfer clean and green technologies in Brazilian academic research groups: Some empirical evidence

2015 ◽  
Vol 13 (9) ◽  
pp. 907-910 ◽  
Author(s):  
Charbel Jose Chiappetta Jabbour ◽  
Ana Beatriz Lopes de Sousa Jabbour
2020 ◽  
Vol 14 (4) ◽  
pp. 324-369 ◽  
Author(s):  
Rafał Rusiecki ◽  
Jakub Witkowski ◽  
Joanna Jaszczewska-Adamczak

Background: Mouse Double Minute 2 protein (MDM2) is a cellular regulator of p53 tumor suppressor (p53). Inhibition of the interaction between MDM2 and p53 proteins is a promising anticancer therapy. Objective: This updated patent review is an attempt to compile the research and achievements of the various researchers working on small molecule MDM2 inhibitors from 2010 to date. We provide an outlook into the future for therapy based on MDM2 inhibition by presenting an overview of the most relevant patents which have recently appeared in the literature. Methods: Literature and recent patents focusing on the anticancer potential of MDM2-p53 interaction inhibitors and its applications have been analyzed. We put the main emphasis on the most perspective compounds which are or were examined in clinical trials. Results: Literature data indicated that MDM2 inhibitors are therapeutically effective in specific types of cancer or non-cancer diseases. A great number of patents and research work around new MDM2- p53 interaction inhibitors, possible combinations, new indications, clinical regimens in previous years prove that this targeted therapy is in the scope of interest for many business and academic research groups. Conclusion: Novel MDM2 inhibitors thanks to higher potency and better ADME properties have shown effectiveness in preclinical and clinical development however the final improvement of therapeutic potential for MDM2 inhibitors might depend on the useful combination therapy and exploring new cancer and non-cancer indications.


Author(s):  
Ken Peach

This chapter discusses the need for cooperation (or collaboration) to be balanced with competition, including between research groups, within a university or laboratory and between the academic research sector and industry. Healthy competition is a great motivator but unhealthy competition can be disastrous. While it is still possible for an individual scientist working alone or with a couple of graduate students or postdocs to make ground-breaking discoveries, today much experimental science requires large teams working collaboratively on a common goal or set of goals. While this trend is most evident in particle physics and astronomy, it is also present in the other physical sciences and the life sciences. Collaboration brings together more resources–physical, financial and intellectual–to address major challenges that would otherwise be beyond the scope of any individual or group. Multidisciplinary research and interdisciplinary research are examples of cooperation between different disciplines.


2013 ◽  
pp. 127-127
Author(s):  
Sandeep K. S. Gupta ◽  
Tridib Mukherjee ◽  
Krishna Kumar Venkatasubramanian

Author(s):  
Wu Hung

The eleventh section of Daode jing (Tao Te Ching), the foundational text of Taoism, reads: . . . Thirty spokes share a hub; Because [the wheel] is empty, it can be used in a cart. Knead clay to make a vessel. Because it is empty, it can function as a vessel. Carve out doors and windows to make a room. Because they are empty, they make a room usable. Thus we possess things and benefit from them, But it is their emptiness that makes them useful. . . This section has always been appreciated as a supreme piece of rhetoric on the powers of nothingness, a philosophical concept fiercely articulated in the Daode jing. Whereas that may indeed be the author’s intention, the empirical evidence evoked to demonstrate this concept reveals an alternative way of seeing manufactured objects by focusing on their immaterial aspects. This way of looking at things has important implications for archaeological and art historical scholarship on ancient artifacts and architecture precisely because these two disciplines identify themselves with the study of physical remains of the past so firmly that tangibility has become an undisputed condition of academic research in these fields. Archaeologists routinely classify objects from an excavation into categories based on material and then inventory their sizes, shapes, and decoration. Art historians typically start their interpretation of images, objects, and monuments by identifying their formal attributes. Whereas such trained attention to material and formal evidence will surely persist for good reasons, the Daode jing section cautions us of the danger of ignoring the immaterial aspects of man-made forms, which, though eluding conventional typological classification and visual analysis, are nevertheless indispensible to their existence as objects and buildings. The current chapter incorporates this approach into a study of ancient Chinese art and visual culture by arguing that constructed empty spaces on artifacts and structures—holes, vacuums, doors, and windows—possess vital significance to understanding the minds and hands that created them and thus deserve a serious look into their meaning.


2020 ◽  
Vol 68 (5) ◽  
pp. 573-580
Author(s):  
Clifton P. Thornton ◽  
Emerald Rivers ◽  
Christopher Rhodes ◽  
Harmeet Kaur Kang ◽  
Tamar Rodney

Author(s):  
Ulrich Steger

This contribution not only tries to place the current debate in the context of developments over the last twenty-five years, but also exhorts academics to design less ‘holistic’ concepts (which easily degenerate into propaganda used in political debate), to contribute to transparency by providing sober empirical evidence, and to express more appreciation for marginal yet continuous incremental improvements in the business world. The public rhetoric about corporate social responsibility has not had any significant effect on everyday life in the corporate sector, nor has the wealth of currently available academic research and suggestions. To put it in a nutshell: even for the most risk-exposed companies or industries, everything beyond the (hard-) core business is of secondary importance. Any empirical evidence is only a snapshot of the status quo. Identifying drivers for change and emerging trends is a more compelling challenge than simply describing the current state of affairs.


2001 ◽  
Vol 7 (S2) ◽  
pp. 816-817
Author(s):  
A. Lazarevich ◽  
B. Carragher ◽  
C.S. Potter ◽  
D. Weber

For the past two years we have been operating a remote instrument educational project called Bugscope. Bugscope is an educational outreach project that provides access to an environmental scanning electron microscope (ESEM) for K-12 classrooms. While the operational aspects of the project require a minimal amount of staff time, the information management for the project is difficult for a small microscopy research group to support without a significant allocation of resources away from the group’s principal research goals. in an effort to alleviate this problem we have begun, in the past five months, to develop a software toolkit called ‘Information Technology for Outreach Projects’ (ITOP) - using the Bugscope project as a test bed. The goal of ITOP is to make it practical for academic research groups to provide scientific resources for educational outreach projects by automating many of the administrative and data handling tasks.


Mediscope ◽  
2017 ◽  
Vol 4 (2) ◽  
pp. 1-4
Author(s):  
MS Laskar

An area of concern in scientific research including medical research is misconduct or dishonesty like fabrication, falsification, or plagiarism in proposing, performing, or reviewing research, or in reporting research results. This article focuses on the concepts of research misconduct with the objectives to discuss briefly on the extent of problem, various forms, possible reasons; methods of detection, and prevention. It is expected that this article will encourage the leaders of academic research groups to inform their students, future researchers and research associates about the ethical responsibilities of scientific research and publications, and to insure that, when they are given the responsibility for research and consequently submitting a paper, they are fully aware of the potential consequences to themselves and to their coauthors for violations of research ethical guidelines.Mediscope Vol. 4, No. 2: Jul 2017, Page 1-4


2016 ◽  
Vol 42 (1) ◽  
pp. 10-32 ◽  
Author(s):  
Esther Hormiga ◽  
Petra de Saá-Pérez ◽  
Nieves L. Díaz-Díaz ◽  
José Luis Ballesteros-Rodríguez ◽  
Inmaculada Aguiar-Diaz

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