Intellectual Systems and Technologies in the Coworking Space Organization

The purpose of the article is to identify the features of the coworking space design, in accordance with the possibilities of using intelligent systems and technologies in the organization of the main and secondary working space zones of the spatial-functional organization. The research methodology is based on the use of theoretical methods: scientometric method, analysis of domestic and foreign experience in the design and construction of the object, analysis of domestic and foreign standards and regulations on the research topic, and empirical methods: structural analysis method, experimental design method, structural method -functional modeling. The scientific novelty of the obtained results lies in the generalization and systematization of the basic techniques and features of the flexible coworking space design. For the first time, the application of intelligent systems and innovative technologies to functional areas of primary and secondary importance has been identified and systematized. Conclusions. As a result of the conducted research the basic regularities of formation of coworking spaces for creation of integral harmonious subject-technical space of the environment of human life were revealed. There are 3 groups of coworking users (owners, employees, residents), according to which the requirements for office space are justified. Functional zoning of coworking allowed to specify the possibilities of using intelligent systems and innovative technologies in each zone and to develop recommendations for their use. As a result of the study, the effectiveness of the use of office furniture and accessories to combine work formats during the day was systematized. The expediency of using intelligent systems to change the working mood to an atmosphere of rest and relaxation, as well as the use of equipment for physical activity in the sports rooms of the coworking space was substantiated. The installation of such intelligent systems and innovative technologies is becoming a clear indicator of the concern for the physical and mental health of residents, which is in line with the latest trends in the use of innovative technologies and intelligent systems.

Assessing the Contribution of Seasonality, Tides, and Microbial Processing to Dissolved Organic Matter Composition Variability in a Southeastern U.S. Estuary

Uncovering which biogeochemical processes have a critical role controlling dissolved organic matter (DOM) compositional changes in complex estuarine environments remains a challenge. In this context, the aim of this study is to characterize the dominant patterns of variability modifying the DOM composition in an estuary off the Southeastern U.S. We collected water samples during three seasons (July and October 2014 and April 2015) at both high and low tides and conducted short- (1 day) and long-term (60 days) dark incubations. Samples were analyzed for bulk DOC concentration, and optical (CDOM) and molecular (FT-ICR MS) compositions and bacterial cells were collected for metatranscriptomics. Results show that the dominant pattern of variability in DOM composition occurs at seasonal scales, likely associated with the seasonality of river discharge. After seasonal variations, long-term biodegradation was found to be comparatively more important in the fall, while tidal variability was the second most important factor correlated to DOM composition in spring, when the freshwater content in the estuary was high. Over shorter time scales, however, the influence of microbial processing was small. Microbial data revealed a similar pattern, with variability in gene expression occurring primarily at the seasonal scale and tidal influence being of secondary importance. Our analyses suggest that future changes in the seasonal delivery of freshwater to this system have the potential to significantly impact DOM composition. Changes in residence time may also be important, helping control the relative contribution of tides and long-term biodegradation to DOM compositional changes in the estuary.

Multi-timescale control of Southern Ocean diapycnal mixing over Atlantic tracer budgets

Oceanic cross-density (diapycnal) mixing helps sustain the ocean den- sity stratification and its Meridional Overturning Circulation (MOC) and is key to global tracer distributions. The Southern Ocean (SO) is a key region where different overturning cells connect, allowing nutri- ent and carbon rich Indian and Pacific deep waters, and oxygen rich Atlantic deep waters to resurface. The SO is also rife with localized intense diapycnal mixing due to breaking of internal waves induced by the interaction of energetic eddies and currents with rough topogra- phy. SO diapycnal mixing is believed to be of secondary importance for the MOC. Here we show that changes to SO mixing can cause sig- nificant alterations to Atlantic biogeochemical tracer distributions over short and long timescales in an idealized model of the MOC. While such alterations are dominated by the direct impact of changes in diapycnal mixing on tracer fluxes on annual to decadal timescales, on centennial timescales they are dominated by the mixing-induced variations in the advective transport of the tracers by the Atlantic MOC. This work sug- gests that an accurate representation of spatio-temporally variable local and non-local mixing processes in the SO is essential for climate mod- els’ ability to i) simulate the biogeochemical cycles and air sea carbon fluxes on decadal timescales, ii) represent the indirect impact of mixing- induced changes to MOC on biogeochemical cycles on longer timescales.

Integrating Enactive and Intercorporeal Approaches to Interaction and Interaction Analysis: d/Deaf Persons and Animals. In Search of the ‘In-Between’ and Adequate Methodologies

"How does understanding occur in encounters of living beings? What is experienced by the interaction partners and what happens in the ‘In-Between’? And how can this be captured? In this paper an enactive approach to interaction is proposed with the focus on reciprocal intercorporeal attunement and co-creation of meaning in a specific environment. As alternative framework this approach is applied to the interaction of d/Deaf persons and animals. In the interaction with an animal, verbal communication - which is challenging for d/Deaf persons - is of secondary importance, so this frame is well suited to focus on intercorporeal attunement. In the interaction discourse regarding d/Deaf persons as well as Human-Animal-Interaction the assessment of the interaction process as such and embodied research methodologies are scarcely to be found. With the enactive approach new perspectives on the mechanisms of interaction and the influencing conditions can be opened as well as new approaches to respective research options. Keywords: d/Deaf, Human-Animal-Interaction, Intercorporeality, Embodied Cognition, Embodied methodologies, Enactive approach, resonance "

Comparison of Unmanned Aerial Vehicle Technology versus Standard Practice of Scene Assessment by Paramedic Students of a Mass-Gathering Event

Introduction: The proliferation of unmanned aerial vehicle (UAV) technology has the potential to change the situational awareness of medical incident commanders’ (ICs’) scene assessment of mass gatherings. Mass gatherings occur frequently and the potential for injury at these events is considered higher than the general population. These events have generated mass-casualty incidents (MCIs) in the past. The aim of this study was to compare UAV technology to standard practice (SP) in scene assessment using paramedic students during a mass-gathering event (MGE). Methods: This study was conducted in two phases. Phase One consisted of validation of the videos and accompanying data collection tool. Phase One was completed by 11 experienced paramedics from a provincial Emergency Medical Services (EMS) service. Phase Two was a randomized comparison with 47 paramedic students from the Holland College Paramedicine Program (Charlottetown, Prince Edward Island, Canada) of the two scene assessment systems. For Phase Two, the paramedic students were randomized into a UAV or a SP group. The data collection tool consisted of two board categories: primary importance with 20 variables and secondary importance with 25 variables. After a brief narrative, participants were either shown UAV footage or the ground footage depending on their study group. After completion of the videos, study participants completed the data collection tool. Results: The Phase One validation showed good consensus in answers to most questions (average 79%; range 55%-100%). For Phase Two, a Fisher’s exact test was used to compare each variable from the UAV and SP groups using a P value of .05. Phase Two demonstrated a significant difference between the SP and UAV groups in four of 20 primary variables. Additionally, significant differences were found for seven out of 25 secondary variables. Conclusion: This study demonstrated the accurate, safe, and feasible use of a UAV as a tool for scene assessment by paramedic students at an MGE. No observed statistical difference was noted in a majority of both primary and secondary variables using a UAV for scene assessment versus SP.

Iron as the concert master in the pathogenic orchestra playing in sporadic Parkinson’s disease

About 60 years ago, the discovery of a deficiency of dopamine in the nigro-striatal system led to a variety of symptomatic therapeutic strategies to supplement dopamine and to substantially improve the quality of life of patients with Parkinson’s disease (PD). Since these seminal developments, neuropathological, neurochemical, molecular biological and genetic discoveries contributed to elucidate the pathology of PD. Oxidative stress, the consequences of reactive oxidative species, reduced antioxidative capacity including loss of glutathione, excitotoxicity, mitochondrial dysfunction, proteasomal dysfunction, apoptosis, lysosomal dysfunction, autophagy, suggested to be causal for ɑ-synuclein fibril formation and aggregation and contributing to neuroinflammation and neural cell death underlying this devastating disorder. However, there are no final conclusions about the triggered pathological mechanism(s) and the follow-up of pathological dysfunctions. Nevertheless, it is a fact, that iron, a major component of oxidative reactions, as well as neuromelanin, the major intraneuronal chelator of iron, undergo an age-dependent increase. And ageing is a major risk factor for PD. Iron is significantly increased in the substantia nigra pars compacta (SNpc) of PD. Reasons for this finding include disturbances in iron-related import and export mechanisms across the blood–brain barrier (BBB), localized opening of the BBB at the nigro-striatal tract including brain vessel pathology. Whether this pathology is of primary or secondary importance is not known. We assume that there is a better fit to the top-down hypotheses and pathogens entering the brain via the olfactory system, then to the bottom-up (gut-brain) hypothesis of PD pathology. Triggers for the bottom-up, the dual-hit and the top-down pathologies include chemicals, viruses and bacteria. If so, hepcidin, a regulator of iron absorption and its distribution into tissues, is suggested to play a major role in the pathogenesis of iron dyshomeostasis and risk for initiating and progressing ɑ-synuclein pathology. The role of glial components to the pathology of PD is still unknown. However, the dramatic loss of glutathione (GSH), which is mainly synthesized in glia, suggests dysfunction of this process, or GSH uptake into neurons. Loss of GSH and increase in SNpc iron concentration have been suggested to be early, may be even pre-symptomatic processes in the pathology of PD, despite the fact that they are progression factors. The role of glial ferritin isoforms has not been studied so far in detail in human post-mortem brain tissue and a close insight into their role in PD is called upon. In conclusion, “iron” is a major player in the pathology of PD. Selective chelation of excess iron at the site of the substantia nigra, where a dysfunction of the BBB is suggested, with peripherally acting iron chelators is suggested to contribute to the portfolio and therapeutic armamentarium of anti-Parkinson medications.

Bacterial Antibiotic Resistance: The Most Critical Pathogens

Antibiotics have made it possible to treat bacterial infections such as meningitis and bacteraemia that, prior to their introduction, were untreatable and consequently fatal. Unfortunately, in recent decades overuse and misuse of antibiotics as well as social and economic factors have accelerated the spread of antibiotic-resistant bacteria, making drug treatment ineffective. Currently, at least 700,000 people worldwide die each year due to antimicrobial resistance (AMR). Without new and better treatments, the World Health Organization (WHO) predicts that this number could rise to 10 million by 2050, highlighting a health concern not of secondary importance. In February 2017, in light of increasing antibiotic resistance, the WHO published a list of pathogens that includes the pathogens designated by the acronym ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) to which were given the highest “priority status” since they represent the great threat to humans. Understanding the resistance mechanisms of these bacteria is a key step in the development of new antimicrobial drugs to tackle drug-resistant bacteria. In this review, both the mode of action and the mechanisms of resistance of commonly used antimicrobials will be examined. It also discusses the current state of AMR in the most critical resistant bacteria as determined by the WHO’s global priority pathogens list.

Removal of iron and sulphate during acid mine drainage treatment using laboratory successive alkalinity producing system and its behavioural relationship

Acid Mine Drainage (AMD) is one of the persistent water pollution problems in many coal mines of U.S.A. and Canada. Only few mines in India face this problem. The treatment of acid mine water has become a statutory requirement in almost all mines of the world. Metal removal and alkalinity generation is essential feature of any AMD treatment system but sulphate removal from acid mine drainage is still given the secondary importance. In the present study, four AMDs were treated in laboratory Successive Alkalinity Producing System (SAPS) for five different hydraulic retention times (HRT). The total iron removal and corresponding sulphate removal along with net alkalinity generation were studied during AMD treatment process by SAPS. A complete removal of total iron and sulphate removal of over 59% have been achieved. The study revealed that the total iron removal and sulphate removal increases with increase in HRT and its removal exhibited linear relationship. A substantial increase in alkalinity was also found after SAPS treatment. The findings of the study can be utilized in design of SAPS for removal of iron and sulphate during treatment of AMD in mining areas.

A Literature Review of MADM Applications for Site Selection Problems — One Decade Review from 2011 to 2020

Site selection is a multi-dimensional optimization problem that influences a wide variety of stakeholders from local communities and authorities to governments, environmental protection agencies, etc. Locating an energy project as well as transportation infrastructure projects, for instance, are of great strategic importance and are connected to the top-level regulations and policy levels. These problems are significant from strategic levels to the productivity of a single construction project level, from energy to transportation and from infrastructure to residential buildings. A large number of publications in this field of study prove this significance. However, regarding the variety of applications, managerial decision levels, and the growing number of studies, it is important to comprehend the latest trends and conclude an appropriate research path in this field. This study is mainly focused on the application of MADM methodologies on locating problems by which many studies are carried out and have a high coincidence with the locating problem environment. Consequently, 425 studies are considered in this study, and 217 more relevant papers are selected for the subsequent reviews. Based on the results, Energy projects are by far the most frequent field of study in this regard which are considered as renewable and nonrenewable categories. Also, environmental planning and sustainable site selection are of secondary importance.