Effects of bovine lactoferrin on the immune system and the intestinal microflora of adult dogs

2008 ◽  
Vol 62 (2) ◽  
pp. 152-161 ◽  
Author(s):  
Petra Hellweg ◽  
Stephanie Krammer-Lukas ◽  
Alois Strasser ◽  
Jürgen Zentek
Keyword(s):  
Immune System ◽  
Intestinal Microflora ◽  
Bovine Lactoferrin

scholarly journals Influence of intestinal microbiota on the immunopathogenesis of atopic dermatitis in children

2021 ◽  
pp. 4-11
Author(s):  
Alexander Viktorovich Zhestkov ◽  
Olga Olegovna Pobezhimova
Keyword(s):  
Atopic Dermatitis ◽  
Immune System ◽  
Intestinal Microbiota ◽  
Intestinal Microflora ◽  
Dynamic Equilibrium ◽  
Clinical Manifestations ◽  
Factors Affecting ◽  
Intestinal Dysbiosis ◽  
Human Intestinal Microbiota ◽  
Th1 Cytokines

Particular attention is paid to atopic dermatitis (AD) as one of the earliest and most frequent clinical manifestations of allergy in children. AD is a multifactorial disease, the development of which is closely related to genetic defects in the immune response and adverse environmental influences. It was found that the action of these factors determines the rate of development of AD, especially in young children. One of these factors is a violation of the intestinal microbiota, which plays an essential role in the development of the child's immune system and has a protective effect in the formation of atopy. It has been shown that 80-95% of patients with AD have intestinal dysbiosis, while, along with a deficiency of lactobacilli and bifidobacteria, there is an excessive growth of Staphilococcus. The use of modern molecular genetics technologies made it possible to obtain a fairly complete understanding of the number, genetic heterogeneity and complexity of the bacterial components of the intestinal microbiota, while clinical studies have shown the importance of its interactions with the host organism in the formation of various forms of pathology. It has been established that the human intestinal microbiota is an evolutionary set of microorganisms that exists as a balanced microecological system in which the symbiotic microflora is in dynamic equilibrium, forms microbial associations that occupy a certain ecological niche in it, and is one of the most important factors affecting human health. The gut microbiota plays an important role in the pathogenesis of atopic dermatitis, which causes immunosuppression, but the exact mechanism of its action is still unclear. It is widely known that probiotics act on the immune system. These are living microorganisms with immunomodulatory effects that stimulate Th1 cytokines and suppress Th2 responses, which are being investigated for the treatment of several diseases. The most commonly used probiotics are part of the intestinal microflora such as lactobacilli, bifidobacteria and enterococci. The purpose of this article: to systematize the information available today on the influence of the composition of the intestinal microflora on the immunopathogenesis of atopic dermatitis.

scholarly journals Immunologic effects of probiotics and human health

2003 ◽  
Vol 24 (1) ◽  
pp. 11 ◽  
Author(s):  
Harsharn Gill
Keyword(s):  
Immune System ◽  
Gastrointestinal Tract ◽  
Infectious Diseases ◽  
Antibiotic Therapy ◽  
Intestinal Microflora ◽  
Healthy Individuals ◽  
Human Gastrointestinal Tract ◽  
Microbial Ecosystem ◽  
Increased Risk ◽  
Gut Homeostasis

The human gastrointestinal tract (GIT) harbours an extremely complex and diverse microbial ecosystem representing over 500 different species. While a majority of indigenous bacteria are benign or beneficial, some possess the potential to cause disease; in healthy individuals, a balance exists between these populations. In addition to nutritional and barrier functions, the intestinal microflora plays an important role in guiding the development of a balanced immune system and maintaining gut homeostasis. Perturbations in the microbial homeostasis due to factors such as antibiotic therapy, stress and infection enhances predisposition to increased risk of infectious diseases, cancers and immunoinflammatory disorders.

Synbiotic effect of Lactobacillus helveticus M92 and prebiotics on the intestinal microflora and immune system of mice

2009 ◽  
Vol 76 (1) ◽  
pp. 98-104 ◽  
Author(s):  
Jadranka Frece ◽  
Blaženka Kos ◽  
Ivan Krešimir Svetec ◽  
Zoran Zgaga ◽  
Jasna Beganović ◽  
...  
Keyword(s):  
Immune System ◽  
Intestinal Microflora ◽  
Oral Treatment ◽  
Lactobacillus Helveticus ◽  
Total Serum ◽  
Humoral Immune ◽  
Serum Iga ◽  
Iga Antibodies ◽  
Small And Large Intestine ◽  
Faecal Microflora

The synbiotic effect of the oral treatment of Swiss albino mice with milk-based diets supplemented with Lactobacillus helveticus M92 and various kinds of prebiotics was investigated. Survival, competition, adhesion and colonization, as well as, immunomodulating capability of Lb. helveticus M92, in synbiotic combination, in the gastrointestinal tract (GIT) of mice, were monitored. After the mice were fed with synbiotics, the lactic acid bacteria (LAB) counts in faeces were increased and reduction of enterobacteria and sulphite-reducing clostridia was observed. Similar results were obtained in homogenates of small and large intestine of mice on the 1st and 14th day, after feeding with synbiotics. After the mice were orally given viable Lb. helveticus M92 cells, alone or in combination with prebiotic, the concentration of faecal SIgA and total serum IgA antibodies from all immunized mice were higher compared with the control. The specific humoral immune response was not evoked after oral administration, therefore their synbiotic application is suitable. Among inulin, lactulose and raffinose, Lb. helveticus M92 in combination with inulin, has shown the best synbiotic effect on intestinal and faecal microflora and immune system of mice.

Lactoferrin reduces colitis in rats via modulation of the immune system and correction of cytokine imbalance

2002 ◽  
Vol 283 (1) ◽  
pp. G187-G195 ◽  
Author(s):  
Jun-Ichi Togawa ◽  
Hajime Nagase ◽  
Katsuaki Tanaka ◽  
Masahiko Inamori ◽  
Tadashi Umezawa ◽  
...  
Keyword(s):  
Immune System ◽  
Distal Colon ◽  
Nuclear Factor Κb ◽  
Bovine Lactoferrin ◽  
Myeloperoxidase Activity ◽  
Intestinal Damage ◽  
Dependent Manner ◽  
Trinitrobenzenesulfonic Acid ◽  
Anti Inflammatory ◽  
Cytokine Imbalance

Natural immunomodulator lactoferrin is known to exert an anti-inflammatory effect. However, there have been no studies that examine the mode of action of lactoferrin in reducing intestinal damage. We investigated the effect of lactoferrin on a trinitrobenzenesulfonic acid (TNBS)-induced colitis model in rats. Bovine lactoferrin was given once daily through gavage, starting 3 days before (preventive mode) or just after TNBS administration (treatment mode) until death. The distal colon was removed to be examined. Colitis was attenuated by lactoferrin via both modes in a dose-dependent manner, as reflected by improvement in macroscopic and histological scores and myeloperoxidase activity. Lactoferrin caused significant induction of the anti-inflammatory cytokines interleukin (IL)-4 and IL-10, significant reductions in the proinflammatory cytokines tumor necrosis factor-α and IL-1β, and downregulation of the nuclear factor-κB pathway. We concluded that lactoferrin exerts a protective effect against colitis in rats via modulation of the immune system and correction of cytokine imbalance. Lactoferrin has potential as a new therapeutic agent for inflammatory bowel disease.

Bovine lactoferrin induces both mucosal and systemic immune response in mice

1998 ◽  
Vol 65 (2) ◽  
pp. 283-293 ◽  
Author(s):  
HAJER DEBBABI ◽  
MICHEL DUBARRY ◽  
MICHÈLE RAUTUREAU ◽  
DANIEL TOMÉ
Keyword(s):  
Body Weight ◽  
Immune System ◽  
Bovine Milk ◽  
Mucosal Immune System ◽  
Control Group ◽  
Bovine Lactoferrin ◽  
Thymidine Uptake ◽  
Intestinal Fluid ◽  
Serum Iga

Lactoferrin (Lf) is a milk iron-binding glycoprotein that plays a role in iron transport and acts as both a bacteriostatic and a growth modulating agent. The aim of this study was to investigate the nature of immune responses induced by repeated oral administration of bovine milk Lf in mice. Groups of ten female BALB/c mice were fed daily for 4 weeks with two doses of protein antigen: a low (0·05 mg/g body weight per d) or high (1 mg/g body weight per d) dose of Lf, or water as a control. A fourth group was immunized intramuscularly with 0·01 mg Lf in complete Freund's adjuvant. Anti-Lf IgA and IgG were detected in the intestinal fluid and serum of mice given Lf. Total immunoglobulins were higher in the intestinal fluid in Lf groups than in the control group. No difference could be detected in the serum. IgA and IgG secretion was enhanced in Peyer's patches and spleen from Lf-fed mice, in comparison with controls. [3H] thymidine uptake into Peyer's patch and spleen cells from both control and Lf-fed mice was enhanced by 75 μg Lf/ml in vitro, but Lf groups had a greater proliferation rate than the control group. These findings suggested that Lf could act as an immunostimulating factor on the mucosal immune system and that activation of the mucosal immune system is dependent on the ability of Lf to bind to the intestinal mucosa.

scholarly journals Direct-Fed Microbials and Their Impact on the Intestinal Microflora and Immune System of Chickens

2010 ◽  
Vol 47 (2) ◽  
pp. 106-114 ◽  
Author(s):  
Kyungwoo Lee ◽  
Hyun S. Lillehoj ◽  
Gregory R. Siragusa
Keyword(s):  
Immune System ◽  
Intestinal Microflora

scholarly journals MORFOLOGICAL CHARACTERISTIC OF IMMUNE SYSTEM OF BALB/C MICE AFTER CORRECTION MICROFLORA DISTURBANCES BY «ENTEROCINE» AND «COLIBACTERINE» PROBIOTICS

2009 ◽  
Vol 17 (1) ◽  
pp. 8
Author(s):  
A. N. Ovcharova ◽  
L. P. Mikhailova ◽  
S. N. Serebryakov ◽  
O. V. Makarova ◽  
Yu. E. Kozlovsky ◽  
...  
Keyword(s):  
Immune System ◽  
Intestinal Microflora ◽  
And Function

Normalization of intestinal microflora disturbances by probiotics «Enterocine» and «Colibacterine» treatment has been revealed after experimental dysbiotical condition, induced by antibiotics. The «Enterocine» is much more effective then «Colibacterine», because of higher content of E.coli and increasing number of Enterococci in intestinal microflora of «Enterocine» treated mice. Both probiotics lead to normalization of thymus and spleen morphology and function.

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