scholarly journals High-risk oncogenic HPV genotype infection associates with increased immune activation and T cell exhaustion in ART-suppressed HIV-1-infected women

2016 ◽  
Vol 5 (5) ◽  
pp. e1128612 ◽  
Author(s):  
Emmanouil Papasavvas ◽  
Lea F. Surrey ◽  
Deborah K. Glencross ◽  
Livio Azzoni ◽  
Jocelin Joseph ◽  
...  
Keyword(s):  
T Cell ◽  
High Risk ◽  
Immune Activation ◽  
T Cell Exhaustion ◽  
Cell Exhaustion ◽  
Hiv 1 ◽  
Genotype Infection ◽  
Oncogenic Hpv

scholarly journals Decreased frequency of CD73+CD8+T cells of HIV-infected patients correlates with immune activation and T cell exhaustion

2013 ◽  
Vol 94 (4) ◽  
pp. 551-561 ◽  
Author(s):  
Ilona Tóth ◽  
Anh Q. Le ◽  
Philip Hartjen ◽  
Adriana Thomssen ◽  
Verena Matzat ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cd8 T Cells ◽  
Immune Activation ◽  
T Cell Exhaustion ◽  
Cell Exhaustion

scholarly journals Inverted CD8 T-Cell Exhaustion and Co-Stimulation Marker Balance Differentiate Aviremic HIV-2-Infected From Seronegative Individuals

2021 ◽  
Vol 12 ◽  
Author(s):  
Lydia Scharf ◽  
Christina B. Pedersen ◽  
Emil Johansson ◽  
Jacob Lindman ◽  
Lars R. Olsen ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Disease Progression ◽  
Cd8 T Cells ◽  
Therapy Monitoring ◽  
Expression Patterns ◽  
Cd8 T Cell ◽  
T Cell Exhaustion ◽  
Cell Exhaustion ◽  
Hiv 1

HIV-2 is less pathogenic compared to HIV-1. Still, disease progression may develop in aviremic HIV-2 infection, but the driving forces and mechanisms behind such development are unclear. Here, we aimed to reveal the immunophenotypic pattern associated with CD8 T-cell pathology in HIV-2 infection, in relation to viremia and markers of disease progression. The relationships between pathological differences of the CD8 T-cell memory population and viremia were analyzed in blood samples obtained from an occupational cohort in Guinea-Bissau, including HIV-2 viremic and aviremic individuals. For comparison, samples from HIV-1- or dually HIV-1/2-infected and seronegative individuals were obtained from the same cohort. CD8 T-cell exhaustion was evaluated by the combined expression patterns of activation, stimulatory and inhibitory immune checkpoint markers analyzed using multicolor flow cytometry and advanced bioinformatics. Unsupervised multidimensional clustering analysis identified a cluster of late differentiated CD8 T-cells expressing activation (CD38+, HLA-DRint/high), co-stimulatory (CD226+/-), and immune inhibitory (2B4+, PD-1high, TIGIThigh) markers that distinguished aviremic from viremic HIV-2, and treated from untreated HIV-1-infected individuals. This CD8 T-cell population displayed close correlations to CD4%, viremia, and plasma levels of IP-10, sCD14 and beta-2 microglobulin in HIV-2 infection. Detailed analysis revealed that aviremic HIV-2-infected individuals had higher frequencies of exhausted TIGIT+ CD8 T-cell populations lacking CD226, while reduced percentage of stimulation-receptive TIGIT-CD226+ CD8 T-cells, compared to seronegative individuals. Our results suggest that HIV-2 infection, independent of viremia, skews CD8 T-cells towards exhaustion and reduced co-stimulation readiness. Further knowledge on CD8 T-cell phenotypes might provide help in therapy monitoring and identification of immunotherapy targets.

Abstract 67: Paralleled convergence of antigen load, disease progression and systemic T cell exhaustion in lung cancer and HIV-1 infection

2021 ◽  
Author(s):  
James L. Reading ◽  
Rachel Rosenthal ◽  
Lucas Black ◽  
Seng Kuong Ung ◽  
Claire Streatfield ◽  
...  
Keyword(s):  
Lung Cancer ◽  
T Cell ◽  
Disease Progression ◽  
T Cell Exhaustion ◽  
Cell Exhaustion ◽  
Hiv 1

scholarly journals A Cinnamon-Derived Procyanidin Compound Displays Anti-HIV-1 Activity by Blocking Heparan Sulfate- and Co-Receptor- Binding Sites on gp120 and Reverses T Cell Exhaustion via Impeding Tim-3 and PD-1 Upregulation

PLoS ONE ◽  
2016 ◽  
Vol 11 (10) ◽  
pp. e0165386 ◽  
Author(s):  
Bridgette Janine Connell ◽  
Sui-Yuan Chang ◽  
Ekambaranellore Prakash ◽  
Rahima Yousfi ◽  
Viswaraman Mohan ◽  
...  
Keyword(s):  
T Cell ◽  
Heparan Sulfate ◽  
Receptor Binding ◽  
Binding Sites ◽  
T Cell Exhaustion ◽  
Cell Exhaustion ◽  
Anti Hiv ◽  
Hiv 1

scholarly journals IL-10 Induces T Cell Exhaustion During Transplantation of Virus Infected Hearts

2016 ◽  
Vol 38 (3) ◽  
pp. 1171-1181 ◽  
Author(s):  
Asmae Gassa ◽  
Fu Jian ◽  
Halime Kalkavan ◽  
Vikas Duhan ◽  
Nadine Honke ◽  
...  
Keyword(s):  
Immune Response ◽  
T Cells ◽  
T Cell ◽  
Organ Transplantation ◽  
Cd8 T Cells ◽  
Immune Activation ◽  
Graft Failure ◽  
Cd8 T Cell ◽  
T Cell Exhaustion ◽  
Cell Exhaustion

Background/Aims: Unexpected transmissions of viral pathogens during solid organ transplantation (SOT) can result in severe, life-threatening diseases in transplant recipients. Immune activation contributes to disease onset. However mechanisms balancing the immune response against transmitted viral infection through organ transplantation remain unknown. Methods & Results: Here we found, using lymphocytic choriomeningitis virus (LCMV), that transplantation of LCMV infected hearts led to exhaustion of virus specific CD8+ T cells, viral persistence in organs and survival of graft and recipient. Genetic depletion of Interleukin-10 (IL-10) resulted in strong immune activation, graft dysfunction and death of mice, suggesting that IL-10 was a major regulator of CD8+ T cell exhaustion during SOT. In the presence of memory CD8+ T cells, virus could be controlled. However sufficient antiviral immune response resulted in acute rejection of transplanted heart. Conclusion: We found that virus transmitted via SOT could not be controlled by naïve mice recipients due to IL-10 mediated CD8+ T cell exhaustion which thereby prevented immunopathology and graft failure whereas memory mice recipients were able to control the virus and induced graft failure.

scholarly journals Loss of DNAM-1 contributes to CD8+T-cell exhaustion in chronic HIV-1 infection

2010 ◽  
Vol 40 (4) ◽  
pp. 949-954 ◽  
Author(s):  
Marina Cella ◽  
Rachel Presti ◽  
William Vermi ◽  
Kerry Lavender ◽  
Emma Turnbull ◽  
...  
Keyword(s):  
T Cell ◽  
Cd8 T Cell ◽  
T Cell Exhaustion ◽  
Cell Exhaustion ◽  
Hiv 1

scholarly journals Highly expression of Tim-3 on HIV-specific T cells associated with disease progression and T-cell exhaustion in HIV-1 infected Chinese

Retrovirology ◽  
2012 ◽  
Vol 9 (Suppl 2) ◽  
pp. P270
Author(s):  
Z Liu ◽  
K Hong ◽  
M Jia ◽  
J Hao ◽  
Z Gao ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Disease Progression ◽  
T Cell Exhaustion ◽  
Cell Exhaustion ◽  
Hiv 1

Reversal of T-cell exhaustion as a strategy to improve immune control of HIV-1

AIDS ◽  
2015 ◽  
Vol 29 (15) ◽  
pp. 1911-1915 ◽  
Author(s):  
John K. Bui ◽  
John W. Mellors
Keyword(s):  
T Cell ◽  
T Cell Exhaustion ◽  
Immune Control ◽  
Cell Exhaustion ◽  
Hiv 1
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