Conductive Nanoporous Membranes: Self-Assembling Block Copolymers for Smart Drug Delivery

Author(s):  
Ece Isenbike Ozalp ◽  
Sungho Kim ◽  
Vignesh Sundar ◽  
Jian-Gang (Jimmy) Zhu ◽  
Jeffrey A. Weldon
2020 ◽  
Vol 21 (8) ◽  
pp. 3342-3352
Author(s):  
Yu-Lun Lo ◽  
Ming-Fong Tsai ◽  
Yugendhar Soorni ◽  
Chin Hsu ◽  
Zi-Xian Liao ◽  
...  

Pharmaceutics ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 300 ◽  
Author(s):  
Amanda Muñoz-Juan ◽  
Aida Carreño ◽  
Rosa Mendoza ◽  
José L. Corchero

The use of smart drug delivery systems (DDSs) is one of the most promising approaches to overcome some of the drawbacks of drug-based therapies, such as improper biodistribution and lack of specific targeting. Some of the most attractive candidates as DDSs are naturally occurring, self-assembling protein nanoparticles, such as viruses, virus-like particles, ferritin cages, bacterial microcompartments, or eukaryotic vaults. Vaults are large ribonucleoprotein nanoparticles present in almost all eukaryotic cells. Expression in different cell factories of recombinant versions of the “major vault protein” (MVP) results in the production of recombinant vaults indistinguishable from native counterparts. Such recombinant vaults can encapsulate virtually any cargo protein, and they can be specifically targeted by engineering the C-terminus of MVP monomer. These properties, together with nanometric size, a lumen large enough to accommodate cargo molecules, biodegradability, biocompatibility and no immunogenicity, has raised the interest in vaults as smart DDSs. In this work we provide an overview of eukaryotic vaults as a new, self-assembling protein-based DDS, focusing in the latest advances in the production and purification of this platform, its application in nanomedicine, and the current preclinical and clinical assays going on based on this nanovehicle.


Nanoscale ◽  
2018 ◽  
Vol 10 (44) ◽  
pp. 20740-20747 ◽  
Author(s):  
Sungho Kim ◽  
Ece Isenbike Ozalp ◽  
Mohamed Darwish ◽  
Jeffrey A. Weldon

We report a novel conductive nanoporous membrane platform for a smart drug delivery system, which allows low-power electrically controlled delivery of therapeutic drug molecules via field-effect gating.


2019 ◽  
Vol 20 (5) ◽  
pp. 1996-2007 ◽  
Author(s):  
Juan Gonzalez-Valdivieso ◽  
Alessandra Girotti ◽  
Raquel Muñoz ◽  
J. Carlos Rodriguez-Cabello ◽  
F. Javier Arias

2013 ◽  
Vol 20 (28) ◽  
pp. 3429-3447 ◽  
Author(s):  
Stefania Pagliari ◽  
Sara Romanazzo ◽  
Diogo Mosqueira ◽  
Perpetua Pinto-do-O ◽  
Takao Aoyagi ◽  
...  

2020 ◽  
Vol 26 (15) ◽  
pp. 1637-1649 ◽  
Author(s):  
Imran Ali ◽  
Sofi D. Mukhtar ◽  
Heyam S. Ali ◽  
Marcus T. Scotti ◽  
Luciana Scotti

Background: Nanotechnology has contributed a great deal to the field of medical science. Smart drugdelivery vectors, combined with stimuli-based characteristics, are becoming increasingly important. The use of external and internal stimulating factors can have enormous benefits and increase the targeting efficiency of nanotechnology platforms. The pH values of tumor vascular tissues are acidic in nature, allowing the improved targeting of anticancer drug payloads using drug-delivery vectors. Nanopolymers are smart drug-delivery vectors that have recently been developed and recommended for use by scientists because of their potential targeting capabilities, non-toxicity and biocompatibility, and make them ideal nanocarriers for personalized drug delivery. Method: The present review article provides an overview of current advances in the use of nanoparticles (NPs) as anticancer drug-delivery vectors. Results: This article reviews the molecular basis for the use of NPs in medicine, including personalized medicine, personalized therapy, emerging vistas in anticancer therapy, nanopolymer targeting, passive and active targeting transports, pH-responsive drug carriers, biological barriers, computer-aided drug design, future challenges and perspectives, biodegradability and safety. Conclusions: This article will benefit academia, researchers, clinicians, and government authorities by providing a basis for further research advancements.


Polymer ◽  
2017 ◽  
Vol 110 ◽  
pp. 235-241 ◽  
Author(s):  
Yanfang Hu ◽  
Ming Deng ◽  
Huailin Yang ◽  
Li Chen ◽  
Chunsheng Xiao ◽  
...  

2021 ◽  
Vol 63 ◽  
pp. 102433
Author(s):  
Sakshi Phogat ◽  
Abhishek Saxena ◽  
Neha Kapoor ◽  
Charu Aggarwal ◽  
Archana Tiwari

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