scholarly journals Involvement of H-2L gene products in virus-immune T-cell recognition. Evidence for an H-2L-restricted T-cell response.

1978 ◽  
Vol 148 (6) ◽  
pp. 1678-1686 ◽  
Author(s):  
W E Biddison ◽  
T H Hansen ◽  
R B Levy ◽  
P C Doherty
Keyword(s):  
T Cell ◽  
T Cell Response ◽  
T Cell Subsets ◽  
Cytotoxic T Cell ◽  
Target Cells ◽  
Similar Response ◽  
Gene Products ◽  
Cell Recognition ◽  
T Cell Recognition ◽  
D Region

The H-2L locus is closely linked to H-2D and codes for antigenic specificities present on a 45,000 mol wt glycoprotein that is distinct from the molecule which bears the D region private specificity. It was found that BALB/c-H-2db mice, which lack detectable cell-surface H-2L gene products, were able to generate influenza- and vaccinia-immune cytotoxic T cells which lyse D region-compatible target cells, although they have been reported to be incapable of making a similar response to ectromelia virus (7). Thus, the lack of H-2L antigenic specificities does not produce a general loss of responsiveness for other viruses even when a highly cross-reactive pox virus (vaccinia) was studied. Antisera-blocking experiments utilizing sera specific for either L or D molecules indicated that BALB/c mice generate influenza virus-immune cytotoxic T-cell subsets which independently recognize H-2L and H-2D gene products in association with viral antigens. These results are the first indication that products of the H-2L locus can operate analogously to H-2K/D gene products in virus-immune T-cell recognition.

Cytotoxic T-cell recognition of influenza-infected target cells varies in different H-2 k mouse strains

1983 ◽  
Vol 18 (2) ◽  
pp. 177-181 ◽  
Author(s):  
Margaret Stringfellow ◽  
David C. Wraith ◽  
Brigitte A. Askonas
Keyword(s):  
T Cell ◽  
Cytotoxic T Cell ◽  
Mouse Strains ◽  
Target Cells ◽  
Cell Recognition ◽  
T Cell Recognition

scholarly journals Cell-mediated lympholysis to H-2-matched target cells modified with a series of nitrophenyl compounds.

1976 ◽  
Vol 144 (4) ◽  
pp. 1134-1140 ◽  
Author(s):  
T G Rehn ◽  
J K Inman ◽  
G M Shearer
Keyword(s):  
T Cell ◽  
Target Cells ◽  
Cell Recognition ◽  
Receptor Model ◽  
Spleen Cells ◽  
Effector Cells ◽  
T Cell Recognition ◽  
Cytotoxic Effector

The specificity of C57BL/10 cytotoxic effector cells generated by in vitro sensitization with autologous spleen cells modified with a series of related nitrophenyl compounds was investigated. The failure of trinitrophenyl (TNP)-sensitized effector cells to lyse TNP-beta-alanylglycylglycyl(AGG)-modified target cells is presented as evidence contradicting the intimacy or dual receptor model or T-cell recognition in its simplest form. Data are also shown indicating that sensitization with N-(3-nitro-4-hydroxy-5-iodophenylacetyl)-AGG-modified stimulating cells generates noncross-reacting clones of cytotoxic effector cells.

scholarly journals Phylodynamic Analysis and Implication of HCV Genotype 4 Variability on Antiviral Drug Response and T-Cell Recognition

Viruses ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 1363
Author(s):  
Giuseppina Maria Elena Colomba ◽  
Noemi Urone ◽  
Vito di Marco ◽  
Donatella Ferraro
Keyword(s):  
T Cell ◽  
Genetic Variability ◽  
Risk Groups ◽  
Cd8 T Cell ◽  
Antiviral Drugs ◽  
T Cell Response ◽  
Cell Recognition ◽  
Genotype 4 ◽  
Hcv Genotype ◽  
T Cell Recognition

Therapies for HCV care could change the prevalence and the geographic distribution of genotypes due to differences in Sustained Virologic Response (SVR). In this scenario, uncommon genotypes/subtypes, such as genotype 4, could spread from high-risk groups, replacing genotypes eradicated by antiviral drugs. Genotype eradication is also strongly influenced by the CD8+ T cell response. In this study, the genetic variability in HCV genotype 4 strains obtained from a cohort of 67 patients naïve to DAA therapy was evaluated. We found that the presence of resistance-associated substitutions (RAS) was able to affect drug responses. Next, using a prediction tool, viral mutations were identified by their ability, or lack thereof, to reduce the binding affinity with HLA, which affects T cell recognition. The Bayesian coalescent analysis suggested two different circulation clusters, one in risk groups (IDUs and MSM) and the other due to migration flows, dated to 1940 and 1915, respectively. Most of the RAS overlapped with HLA and a lack of binding mutations was observed in 96% of strains. This study describes the introduction of HCV genotype 4 in a region of the Mediterranean basin and evaluates how HCV genotype 4’s genetic variability could affect the response of antiviral drugs and CD8+ T cell recognition.

scholarly journals CD8+ T-cell recognition of human cytomegalovirus latency-associated determinant pUL138

2010 ◽  
Vol 91 (8) ◽  
pp. 2040-2048 ◽  
Author(s):  
Siok-Keen Tey ◽  
Felicia Goodrum ◽  
Rajiv Khanna
Keyword(s):  
T Cells ◽  
T Cell ◽  
Human Cytomegalovirus ◽  
Cell Response ◽  
Hcmv Infection ◽  
Mononuclear Cells ◽  
T Cell Response ◽  
Cell Recognition ◽  
T Cell Recognition ◽  
Infected Cells

Recent studies have shown that long-term persistence of human cytomegalovirus (HCMV) in mononuclear cells of myeloid lineage is dependent on the UL138 open reading frame, which promotes latent infection. Although T-cell recognition of protein antigens from all stages of lytic HCMV infection is well established, it is not clear whether proteins expressed during latent HCMV infection can also be recognized. This study conducted an analysis of T-cell response towards proteins associated with HCMV latency. Ex vivo analysis of T cells from healthy virus carriers revealed a dominant CD8+ T-cell response to the latency-associated pUL138 protein, which recognized a non-canonical 13 aa epitope in association with HLA-B*3501. These pUL138-specific T cells displayed a range of memory phenotypes that were in general less differentiated than that previously described in T cells specific for HCMV lytic antigens. Antigen-presentation assays revealed that endogenous pUL138 could be presented efficiently by HCMV-infected cells. However, T-cell recognition of pUL138 was dependent on newly synthesized protein, with little presentation from stable, long-lived protein. These data demonstrate that T cells targeting latency-associated protein products exist, although HCMV may limit the presentation of latent proteins, thereby restricting T-cell recognition of latently infected cells.

scholarly journals Antigenic diversity in the circumsporozoite protein of Plasmodium falciparum abrogates cytotoxic-T-cell recognition.

1994 ◽  
Vol 62 (4) ◽  
pp. 1410-1413 ◽  
Author(s):  
V Udhayakumar ◽  
Y P Shi ◽  
S Kumar ◽  
D L Jue ◽  
R M Wohlhueter ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
T Cell ◽  
Circumsporozoite Protein ◽  
Cytotoxic T Cell ◽  
Cell Recognition ◽  
Antigenic Diversity ◽  
T Cell Recognition

Cytotoxic T Cell Recognition of the SV40 Tumor Antigen: A Note of Caution

1988 ◽  
pp. 87-95 ◽  
Author(s):  
LINDA R. GOODING ◽  
KATHRYN A. O'CONNELL ◽  
ROY GEIB ◽  
JAMES M. PIPAS
Keyword(s):  
T Cell ◽  
Tumor Antigen ◽  
Cytotoxic T Cell ◽  
Cell Recognition ◽  
T Cell Recognition ◽  
Antigen A
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