scholarly journals Phylodynamic Analysis and Implication of HCV Genotype 4 Variability on Antiviral Drug Response and T-Cell Recognition

Viruses ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 1363
Author(s):  
Giuseppina Maria Elena Colomba ◽  
Noemi Urone ◽  
Vito di Marco ◽  
Donatella Ferraro
Keyword(s):  
T Cell ◽  
Genetic Variability ◽  
Risk Groups ◽  
Cd8 T Cell ◽  
Antiviral Drugs ◽  
T Cell Response ◽  
Cell Recognition ◽  
Genotype 4 ◽  
Hcv Genotype ◽  
T Cell Recognition

Therapies for HCV care could change the prevalence and the geographic distribution of genotypes due to differences in Sustained Virologic Response (SVR). In this scenario, uncommon genotypes/subtypes, such as genotype 4, could spread from high-risk groups, replacing genotypes eradicated by antiviral drugs. Genotype eradication is also strongly influenced by the CD8+ T cell response. In this study, the genetic variability in HCV genotype 4 strains obtained from a cohort of 67 patients naïve to DAA therapy was evaluated. We found that the presence of resistance-associated substitutions (RAS) was able to affect drug responses. Next, using a prediction tool, viral mutations were identified by their ability, or lack thereof, to reduce the binding affinity with HLA, which affects T cell recognition. The Bayesian coalescent analysis suggested two different circulation clusters, one in risk groups (IDUs and MSM) and the other due to migration flows, dated to 1940 and 1915, respectively. Most of the RAS overlapped with HLA and a lack of binding mutations was observed in 96% of strains. This study describes the introduction of HCV genotype 4 in a region of the Mediterranean basin and evaluates how HCV genotype 4’s genetic variability could affect the response of antiviral drugs and CD8+ T cell recognition.

Immunomodulation and RNA interference alter Hepatitis B Virus‐specific CD8 T cell recognition of infected HepG2‐NTCP

Hepatology ◽  
2021 ◽  
Author(s):  
Adrian Kuipery ◽  
Juan Diego Sanchez Vasquez ◽  
Aman Mehrotra ◽  
Jordan J. Feld ◽  
Harry L. A. Janssen ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Rna Interference ◽  
T Cell ◽  
Hepatitis B ◽  
Cd8 T Cell ◽  
Cell Recognition ◽  
T Cell Recognition ◽  
B Virus

PS-079-HDV co-infection modifies the immunoproteasome profile of HBV infected hepatocytes leading to increased CD8 T-cell recognition: Implication for immunotherapy

2019 ◽  
Vol 70 (1) ◽  
pp. e51
Author(s):  
Christine Y.L. Tham ◽  
Janine Kah ◽  
Anthony Tan ◽  
Alessandro Loglio ◽  
Camille Sureau ◽  
...  
Keyword(s):  
T Cell ◽  
Cd8 T Cell ◽  
Cell Recognition ◽  
T Cell Recognition

scholarly journals HIV Controllers Exhibit Effective CD8+ T Cell Recognition of HIV-1-Infected Non-activated CD4+ T Cells

Cell Reports ◽  
2019 ◽  
Vol 27 (1) ◽  
pp. 142-153.e4 ◽  
Author(s):  
Blandine Monel ◽  
Annmarie McKeon ◽  
Pedro Lamothe-Molina ◽  
Priya Jani ◽  
Julie Boucau ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cd4 T Cells ◽  
Cd8 T Cell ◽  
Cell Recognition ◽  
T Cell Recognition ◽  
Hiv Controllers ◽  
Hiv 1

scholarly journals Enhancement in Specific CD8+ T Cell Recognition of EphA2+ Tumors In Vitro and In Vivo after Treatment with Ligand Agonists

2008 ◽  
Vol 181 (11) ◽  
pp. 7721-7727 ◽  
Author(s):  
Amy K. Wesa ◽  
Christopher J. Herrem ◽  
Maja Mandic ◽  
Jennifer L. Taylor ◽  
Cecilia Vasquez ◽  
...  
Keyword(s):  
T Cell ◽  
Cd8 T Cell ◽  
Cell Recognition ◽  
T Cell Recognition

scholarly journals Microenvironmental stresses induce HLA-E/Qa-1 surface expression and thereby reduce CD8+T-cell recognition of stressed cells

2016 ◽  
Vol 46 (4) ◽  
pp. 929-940 ◽  
Author(s):  
Takanori Sasaki ◽  
Takayuki Kanaseki ◽  
Yosuke Shionoya ◽  
Serina Tokita ◽  
Sho Miyamoto ◽  
...  
Keyword(s):  
T Cell ◽  
Cd8 T Cell ◽  
Surface Expression ◽  
Cell Recognition ◽  
T Cell Recognition ◽  
Stressed Cells

scholarly journals CD8+ T-cell recognition of human cytomegalovirus latency-associated determinant pUL138

2010 ◽  
Vol 91 (8) ◽  
pp. 2040-2048 ◽  
Author(s):  
Siok-Keen Tey ◽  
Felicia Goodrum ◽  
Rajiv Khanna
Keyword(s):  
T Cells ◽  
T Cell ◽  
Human Cytomegalovirus ◽  
Cell Response ◽  
Hcmv Infection ◽  
Mononuclear Cells ◽  
T Cell Response ◽  
Cell Recognition ◽  
T Cell Recognition ◽  
Infected Cells

Recent studies have shown that long-term persistence of human cytomegalovirus (HCMV) in mononuclear cells of myeloid lineage is dependent on the UL138 open reading frame, which promotes latent infection. Although T-cell recognition of protein antigens from all stages of lytic HCMV infection is well established, it is not clear whether proteins expressed during latent HCMV infection can also be recognized. This study conducted an analysis of T-cell response towards proteins associated with HCMV latency. Ex vivo analysis of T cells from healthy virus carriers revealed a dominant CD8+ T-cell response to the latency-associated pUL138 protein, which recognized a non-canonical 13 aa epitope in association with HLA-B*3501. These pUL138-specific T cells displayed a range of memory phenotypes that were in general less differentiated than that previously described in T cells specific for HCMV lytic antigens. Antigen-presentation assays revealed that endogenous pUL138 could be presented efficiently by HCMV-infected cells. However, T-cell recognition of pUL138 was dependent on newly synthesized protein, with little presentation from stable, long-lived protein. These data demonstrate that T cells targeting latency-associated protein products exist, although HCMV may limit the presentation of latent proteins, thereby restricting T-cell recognition of latently infected cells.

scholarly journals CD8+ T cell Recognition of Polymorphic Wild Type Sequence p53 65–73 Peptides in Squamous Cell Carcinoma of the Head and Neck

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Pedro Alcantara Andrade Filho ◽  
Daisuke Ito ◽  
Theresa L Whiteside ◽  
Albert DeLeo ◽  
Robert L Ferris
Keyword(s):  
Squamous Cell Carcinoma ◽  
T Cell ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Cd8 T Cell ◽  
Cell Recognition ◽  
Wild Type ◽  
T Cell Recognition ◽  
Type Sequence

scholarly journals Profound CD8 T cell responses towards the SARS-CoV-2 ORF1ab in COVID-19 patients

2020 ◽  
Author(s):  
Anastasia Gangaev ◽  
Steven L. C. Ketelaars ◽  
Sanne Patiwael ◽  
Anna Dopler ◽  
Olga I. Isaeva ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
T Cell Response ◽  
Clinical Activity ◽  
Cell Reactivity ◽  
T Cell Recognition ◽  
Cell Responses ◽  
T Cell Reactivity ◽  
Very High

Abstract A large global effort is currently ongoing to develop vaccines against SARS-CoV-2, the causative agent of COVID-19. While there is accumulating evidence on the antibody response against SARS-CoV-2, little is known about the SARS-CoV-2 antigens that are targeted by CD8 T cells. To address this issue, we have analyzed samples from 20 COVID-19 patients for T cell recognition of 500 predicted MHC class I epitopes. CD8 T cell reactivity against SARS-CoV- 2 was common. Remarkably, a substantial fraction of the observed CD8 T cell responses were directed towards the ORF1ab polyprotein 1ab, and these CD8 T cell responses were frequently of a very high magnitude. The fact that a major part of the SARS-CoV-2 specific CD8 T cell response is directed against a part of the viral genome that is not included in the majority of vaccine candidates currently in development may potentially influence their clinical activity and toxicity profile.

scholarly journals Rhoptry and Dense Granule Secreted Effectors Regulate CD8+ T Cell Recognition of Toxoplasma gondii Infected Host Cells

2019 ◽  
Vol 10 ◽  
Author(s):  
Leah M. Rommereim ◽  
Barbara A. Fox ◽  
Kiah L. Butler ◽  
Viviana Cantillana ◽  
Gregory A. Taylor ◽  
...  
Keyword(s):  
T Cell ◽  
Toxoplasma Gondii ◽  
Cd8 T Cell ◽  
Dense Granule ◽  
Host Cells ◽  
Infected Host ◽  
Cell Recognition ◽  
T Cell Recognition
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