Phosphorylated Peptides Are Naturally Processed and Presented by Major Histocompatibility Complex Class I Molecules in Vivo
2000 ◽
Vol 192
(12)
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pp. 1755-1762
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Posttranslational modification of peptide antigens has been shown to alter the ability of T cells to recognize major histocompatibility complex (MHC) class I–restricted peptides. However, the existence and origin of naturally processed phosphorylated peptides presented by MHC class I molecules have not been explored. By using mass spectrometry, significant numbers of naturally processed phosphorylated peptides were detected in association with several human MHC class I molecules. In addition, CD8+ T cells could be generated that specifically recognized a phosphorylated epitope. Thus, phosphorylated peptides are part of the repertoire of antigens available for recognition by T cells in vivo.
1997 ◽
Vol 186
(11)
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pp. 1809-1818
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1993 ◽
Vol 178
(6)
◽
pp. 1971-1980
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1993 ◽
Vol 177
(1)
◽
pp. 201-205
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1992 ◽
Vol 176
(1)
◽
pp. 89-97
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1993 ◽
Vol 13
(3)
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pp. 1554-1564
2002 ◽
Vol 76
(13)
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pp. 6425-6434
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