scholarly journals The road from Rous sarcoma virus to precision medicine

2021 ◽  
Vol 218 (4) ◽  
Author(s):  
Olivier Elemento
Keyword(s):  
Cancer Research ◽  
Precision Medicine ◽  
Rous Sarcoma Virus ◽  
The Road ◽  
Rous Sarcoma ◽  
Sarcoma Virus ◽  
Modern Era

In 1911, more than a century ago, Peyton Rous described a curious observation, later explained by a virus named for him that led to the discovery of oncogenes, the modern era of cancer research, and the emergent field of precision medicine (1911. J. Exp. Med. https://doi.org/10.1084/jem.13.4.397).

scholarly journals 50th anniversary of the discovery of reverse transcriptase

2021 ◽  
Vol 32 (2) ◽  
pp. 91-97
Author(s):  
John M. Coffin
Keyword(s):  
Cancer Research ◽  
Reverse Transcriptase ◽  
Paradigm Shift ◽  
Rous Sarcoma Virus ◽  
50Th Anniversary ◽  
Theoretical Base ◽  
Simple Experiment ◽  
Rous Sarcoma ◽  
Sarcoma Virus ◽  
Simultaneous Discovery

The simultaneous discovery in 1970 of reverse transcriptase in virions of retroviruses by Howard Temin and David Baltimore was perhaps the most dramatic scientific moment of the second half of the 20th century. Ten years previously, Temin’s observation of cells transformed by Rous Sarcoma virus led him to the conclusion that retroviruses replicate through a DNA intermediate he called the provirus. This heretical hypothesis was greeted with derision by fellow scientists; Temin and Baltimore performed a simple experiment, rapidly reproduced, and convincing to all. Its result was a major paradigm shift—reversal of the central dogma of molecular biology. It immediately grabbed the attention of both the scientific and lay press. It also came at a key time for cancer research, at the start of the “War on Cancer.” As a theoretical base and fundamental molecular tool, it enabled a decade of (largely fruitless) search for human oncogenic retroviruses but laid the foundation for the discovery of HIV 13 years later, leading to the development of effective therapy. I had the good fortune, as a student in Temin’s lab, to witness these events. I am honored to be able to share my recollection on the occasion of their 50th anniversary.

Role of the mitogenic property and kinase activity of p60src in tumor formation by Rous sarcoma virus.

1984 ◽  
Vol 49 (2) ◽  
pp. 325-332 ◽  
Author(s):  
F Poirier ◽  
P Jullien ◽  
P Dezelee ◽  
G Dambrine ◽  
E Esnault ◽  
...  
Keyword(s):  
Rous Sarcoma Virus ◽  
Kinase Activity ◽  
Tumor Formation ◽  
Rous Sarcoma ◽  
Sarcoma Virus
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