scholarly journals STUDIES ON THE HEMOLYTIC STREPTOCOCCUS OF HUMAN ORIGIN

1935 ◽  
Vol 61 (4) ◽  
pp. 515-530 ◽  
Author(s):  
Hugh K. Ward ◽  
Champ Lyons
Keyword(s):  
Human Blood ◽  
Blood Stream ◽  
Streptococcal Infections ◽  
Human Origin ◽  
Common Variants ◽  
Hemolytic Streptococcus ◽  
Reliable Test ◽  
Laboratory Cultures

1. Four common variants of the hemolytic streptococcus of human origin have been described. These have been designated the F, M, attenuated M, and C variants. 2. The F and M variants only have been isolated from the blood stream in streptococcal infections. Only the M, however, has any primary virulence for the mouse. 3. Both these variants resist phagocytosis in human blood under suitable conditions, and this appears to be a reliable test for human virulence. 4. The attenuated M variant, found only in laboratory cultures, has a capsule as well developed as that of the virulent variants, and yet does not resist phagocytosis. 5. The C variant has no capsule and is readily phagocyted. It appears to correspond to the avirulent variant in other species. 6. An attempt has been made to correlate these four variants with those already described in the literature. 7. The application of these findings to the problem of virulence has been discussed.

STUDIES IN THE RELATION OF THE HEMOLYTIC STREPTOCOCCUS TO RHEUMATIC FEVER

PEDIATRICS ◽  
1949 ◽  
Vol 3 (4) ◽  
pp. 482-503
Author(s):  
T. N. HARRIS ◽  
SUSANNA HARRIS ◽  
RUTH L. NAGLE
Keyword(s):  
Rheumatic Fever ◽  
Streptococcal Infection ◽  
Laboratory Diagnosis ◽  
Diagnostic Value ◽  
The Other ◽  
Streptococcal Infections ◽  
Hemolytic Streptococcus ◽  
Streptococcal Antigens ◽  
The Mean

Titrations of antibodies to four streptococcal antigens have been carried out in the sera of patients with rheumatic fever and of convalescents from streptococcal infections. These antigens are the hyaluronidase, the hemolysin, and two somatic fractions, the cytoplasmic particles and supernate proteins. Mean titers to all of these antigens were elevated in both rheumatic and streptococcal infection. The mean titer was somewhat higher in rheumatic than in streptococcal infection in the case of three of these antibodies. In the case of the fourth, antihyaluronidase, this difference was considerably greater. The antihyaluronidase titer showed better correlation with changes in the activity of the rheumatic infection than did the other tests. There was, however, no striking correlation between this titer and the severity of the illness. Application was made of these findings to the problem of laboratory diagnosis of rheumatic fever by streptococcal serology. A method is presented for assessing the relative usefulness of such tests in terms of the, distribution of their titers in this disease and in health. By this method the antihyaluronidase test was found to be most useful of the four. The comparative diagnostic value for rheumatic fever was studied in the case of the antihyaluronidase test, the antistreptolysin test, and of combinations of both tests.

A Maternal-Neonatal Outbreak of Infections Due to an Unusual Group A β-Hemolytic Streptococcus

1984 ◽  
Vol 5 (6) ◽  
pp. 271-274 ◽  
Author(s):  
Andrew M. Wiesenthal
Keyword(s):  
Umbilical Cord ◽  
Streptococcal Infections ◽  
Sitz Bath ◽  
Cord Care ◽  
Hemolytic Streptococcus ◽  
Appropriate Treatment ◽  
Umbilical Cord Care ◽  
Group A ◽  
The Common

AbstractAn outbreak of group A β-hemolytic streptococcal infections involving three parturients, three newborns, and a nursery RN is reported. Six of six organisms available for serotyping were M-untypable, T-11, serum opacity reaction-negative. Propagation of the outbreak may have been fostered by the common use of a single sitz bath, although the evidence to support this is weak. The outbreak was rapidly controlled via strict cohorting, appropriate treatment and isolation of cases, and the routine use of triple dye for umbilical cord care.

scholarly journals THE OCCURRENCE OF MUCOID POLYSACCHARIDE IN HEMOLYTIC STREPTOCOCCI OF HUMAN ORIGIN

1943 ◽  
Vol 77 (1) ◽  
pp. 21-28 ◽  
Author(s):  
C. V. Seastone
Keyword(s):  
Rapid Method ◽  
Quantitative Estimation ◽  
Streptococcal Infections ◽  
Human Origin ◽  
Probable Significance ◽  
Group A ◽  
Lancefield Group

1. A rapid method for the roughly quantitative estimation of mucoid polysaccharide in hemolytic streptococci has been described. 2. Using this method, about 94 per cent of strains from moderate or severe streptococcal infections in man have been found to produce mucoid polysaccharide in greater or less amount. In a group of streptococci from normal throats only about 8 per cent produced this substance, all of the producers falling into Lancefield's group A. 3. Of the Lancefield group A strains from both normal and infected sources, 92 per cent showed the presence of mucoid polysaccharide in culture dilutions of 1:10 or higher. 4. The probable significance of the mucoid polysaccharide in streptococcal virulence is indicated.

scholarly journals Metabolic labelling of cancer cells with glycodendrimers stimulate immune-mediated cytotoxicity.

2021 ◽  
Author(s):  
David Goyard ◽  
Peremobowei Iyanu DIRIWARI ◽  
Nathalie Berthet
Keyword(s):  
Cancer Cells ◽  
Human Blood ◽  
Blood Stream ◽  
Metabolic Labelling ◽  
Immune Mediated ◽  
Immunotherapeutic Strategy

The recruitment of antibody naturally present in human blood stream at the surface of cancer cells have been proved a promising immunotherapeutic strategy to fight cancer. Antibody recruiting molecules (ARMs)...

scholarly journals Ex vivo electric power generation in human blood using an enzymatic fuel cell in a vein replica

RSC Advances ◽  
2016 ◽  
Vol 6 (74) ◽  
pp. 70215-70220 ◽  
Author(s):  
Dmitry Pankratov ◽  
Lars Ohlsson ◽  
Petri Gudmundsson ◽  
Sanela Halak ◽  
Lennart Ljunggren ◽  
...  
Keyword(s):  
Power Generation ◽  
Fuel Cell ◽  
Electric Power ◽  
Human Blood ◽  
Electricity Generation ◽  
Ex Vivo ◽  
Blood Stream ◽  
Biofuel Cell ◽  
Enzymatic Fuel Cell ◽  
Proof Of Principle

Proof-of-principle demonstration of sustained electricity generation by a biofuel cell operating in an authentic human blood stream.

scholarly journals NORMAL AND PATHOLOGICAL FRAGMENTATION OF RED BLOOD CELLS; THE PHAGOCYTOSIS OF THESE FRAGMENTS BY DESQUAMATED ENDOTHELIAL CELLS OF THE BLOOD STREAM; THE CORRELATION OF THE PEROXIDASE REACTION WITH PHAGOCYTOSIS IN MONONUCLEAR CELLS

1926 ◽  
Vol 43 (6) ◽  
pp. 839-850 ◽  
Author(s):  
Charles A. Doan ◽  
Florence R. Sabin
Keyword(s):  
Endothelial Cells ◽  
Red Blood Cells ◽  
Human Blood ◽  
Blood Cells ◽  
Mononuclear Cells ◽  
Blood Stream ◽  
Red Cells ◽  
Peroxidase Reaction ◽  
Rabbit Blood ◽  
Oxidase Reaction

1. There is constantly some breaking down of red cells in the circulation by fragmentation. 2. The fragments of red cells, as well as whole red cells, are phagocytized and destroyed by clasmatocytes or endothelial phagocytes. 3. When there is an increase in fragmentation in abnormal or pathological states, desquamated endothelial cells of the blood stream, as well as the clasmatocytes of the tissues, increase proportionately and take in these fragments. These cells are to be distinguished from eosinophilic leucocytes by the nature of their granules, by the type of motility of the cells, and by a negative peroxidase test. 4. The desquamated endothelial cells, clasmatocytes, in the circulating blood are positive to the peroxidase test only when they have taken in positive material. 5. The monocytes show marked variations of the oxidase reaction in different species and to different techniques. With the Sato and Sekiya technique most monocytes of human blood are positive, while most of them in rabbit blood are negative, but both positive and negative reactions are found in both human and rabbit blood.

Population inhibitors in cultures of Bulinus truncatus rohlfsi

1994 ◽  
Vol 72 (5) ◽  
pp. 847-855 ◽  
Author(s):  
Matthew G. Leopard ◽  
Hadar Isseroff
Keyword(s):  
Molecular Weight ◽  
Population Density ◽  
Human Blood ◽  
Schistosoma Haematobium ◽  
Culture Media ◽  
Snail Host ◽  
Inhibitory Effects ◽  
Bulinus Truncatus ◽  
Laboratory Cultures ◽  
Series Of Experiments

Bulinus truncatus rohlfsi is a snail host of the human blood fluke Schistosoma haematobium. Observations on the dynamics of laboratory cultures of B. t. rohlfsi are presented from a series of experiments that investigated the effects of population density, pH, and oxygen concentration, and the inhibitory effects of old snail culture media. The data suggest that survival and fecundity are density dependent and that the cause of this effect is a fairly thermostable compound with a molecular weight <1000.

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